scholarly journals Abnormal laboratory values during the acute and recovery phases in schizophrenic patients: a retrospective study

2010 ◽  
pp. 281
Author(s):  
Mike Briley ◽  
Takahiko Nagamine
Keyword(s):  
Retrospective Study ◽  
Abnormal Laboratory ◽  
Laboratory Values ◽  
Schizophrenic Patients

Retrospective Study on the Effects of Long-Term Use of Methylprednisolone Acetate on the Blood Work of 25 Cats

2019 ◽  
Vol 55 (1) ◽  
pp. 23-28
Author(s):  
Joanne Sohn ◽  
Theresa Gruber ◽  
Gaylord M. Brown
Keyword(s):  
Retrospective Study ◽  
Blood Count ◽  
Complete Blood Count ◽  
Reference Interval ◽  
Parenteral Administration ◽  
Methylprednisolone Acetate ◽  
Abnormal Laboratory ◽  
Laboratory Values

ABSTRACT Twenty-five cats at a private animal sanctuary received multiple nonimmunosuppressive doses of parenteral methylprednisolone acetate for at least 3 yr. Complete blood count, chemistry, and T4 results from these cats were examined to look for statistically significant changes. Results found significant changes in triglycerides, amylase, and monocytes. However, these changes remained within the reference interval. All other values showed no significant changes. These results suggest that after 3 yr of chronic parenteral administration of nonimmunosuppressive doses of methylprednisolone acetate, the complete blood count, chemistry, and T4 values in 25 cats were not significantly affected and did not result in abnormal laboratory values.

Clinical variables related to suicide attempts in schizophrenic patients: a retrospective study

2003 ◽  
Vol 60 (1) ◽  
pp. 47-55 ◽  
Author(s):  
A.C. Altamura ◽  
R. Bassetti ◽  
S. Bignotti ◽  
R. Pioli ◽  
E. Mundo
Keyword(s):  
Retrospective Study ◽  
Suicide Attempts ◽  
Clinical Variables ◽  
Schizophrenic Patients

scholarly journals Primary care pediatricians’ interest in diagnostic error reduction

Diagnosis ◽  
2016 ◽  
Vol 3 (2) ◽  
pp. 65-69 ◽  
Author(s):  
Michael L. Rinke ◽  
Hardeep Singh ◽  
Sarah Ruberman ◽  
Jason Adelman ◽  
Steven J. Choi ◽  
...  
Keyword(s):  
Delayed Diagnosis ◽  
Diagnostic Errors ◽  
Diagnostic Error ◽  
Error Reduction ◽  
Self Report ◽  
Abnormal Laboratory ◽  
Electronic Survey ◽  
Laboratory Values ◽  
Life Threatening

Abstract: Diagnostic errors causing harm in children are understudied, resulting in a knowledge gap regarding pediatricians’ interest in reducing their incidence.: Electronic survey of general pediatricians focusing on diagnostic error incidence, errors they were interested in trying to improve, and errors reduced by their electronic health record (EHR).: Of 300 contacted pediatricians, 77 (26%) responded, 58 (19%) served ambulatory patients, and 48 (16%) completed the entire questionnaire. Of these 48, 17 (35%) reported making a diagnostic error at least monthly, and 16 (33%) reported making a diagnostic error resulting in an adverse event at least annually. Pediatricians were “most” interested in “trying to improve” missed diagnosis of hypertension (17%), delayed diagnosis due to missed subspecialty referral (15%), and errors associated with delayed follow-up of abnormal laboratory values (13%). Among the 44 pediatricians with an EHR, 16 (36%) said it reduced the likelihood of missing obesity and 14 (32%) said it reduced the likelihood of missing hypertension. Also, 15 (34%) said it helped avoid delays in follow-up of abnormal laboratory values. A third (36%) reported no help in diagnostic error reduction from their EHR.: Pediatricians self-report an appreciable number of diagnostic errors and were most interested in preventing high frequency, non-life-threatening errors. There exists a need to leverage EHRs to support error reduction efforts.

Monitoring Abnormal Laboratory Values as Antecedents to Drug-Induced Injury

2005 ◽  
Vol 59 (6) ◽  
pp. 1457-1462 ◽  
Author(s):  
Sandra L. Kane-Gill ◽  
Joseph F. Dasta ◽  
Philip J. Schneider ◽  
Charles H. Cook
Keyword(s):  
Drug Induced ◽  
Abnormal Laboratory ◽  
Laboratory Values

scholarly journals Prediction model for Prolonged fever in patients with Mycoplasma pneumoniae pneumonia : A retrospective study of 716 pediatric patients

2020 ◽  
Author(s):  
Min Sik Jang ◽  
Bit Kyeol Kim ◽  
Jihye Kim
Keyword(s):  
Neural Network ◽  
Retrospective Study ◽  
Prediction Model ◽  
Mycoplasma Pneumoniae ◽  
Prediction Models ◽  
Laboratory Data ◽  
Predictive Values ◽  
Prolonged Fever ◽  
Laboratory Values ◽  
Increased Sensitivity

Abstract Background: To identify patients with Mycoplasma pneumoniae pneumonia (MPP) with a risk of prolonged fever while on macrolides. Methods: A retrospective study was performed with 716 children admitted for MPP. Refractory MPP (RMPP) was defined as fever persisting for >72 hours after macrolide antibiotics (RMPP-3) or when fever persisted for >120 hours (RMPP-5). Radiological data, laboratory data, and fever profiles were compared between the RMPP and non-RMPP groups. Fever profiles included the highest temperature, lowest temperature, and frequency of fever. Prediction models for RMPP were created using the logistic regression method and deep neural network. Their predictive values were compared using receiver operating characteristic curves.Results: Overall, 716 patients were randomly divided into two groups: training and test cohorts for both RMPP-3 and RMPP-5. For the prediction of RMPP-3, a conventional logistic model with radiologic grouping showed increased sensitivity (63.3%) than the model using laboratory values. Adding laboratory values in the prediction model using radiologic grouping did not contribute to a meaningful increase in sensitivity (64.6%). For the prediction of RMPP-5, laboratory values or radiologic grouping showed lower sensitivities ranging from 12.9%–16.1%. However, prediction models using predefined fever profiles showed significantly increased sensitivity for predicting RMPP-5, and neural network models using 12 sequential fever data showed a greatly increased sensitivity (64.5%).Conclusions: RMPP-5 could not be effectively predicted using initial laboratory and radiologic data, which were previously reported to be predictive. Further studies using advanced mathematical models, based on large-sized easily accessible clinical data, are anticipated for predicting RMPP.

Applying Diagnostic Criteria for Type 1 von Willebrand Disease to a Pediatric Population.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 2138-2138
Author(s):  
Sarah A. Hyatt ◽  
Wei Wang ◽  
Bryce A. Kerlin ◽  
Sarah H. O’Brien
Keyword(s):  
Diagnostic Criteria ◽  
Pediatric Population ◽  
Von Willebrand Disease ◽  
Abnormal Laboratory ◽  
Laboratory Values ◽  
Bleeding Score ◽  
Definition Of ◽  
Von Willebrand ◽  
Mucocutaneous Bleeding

Abstract Background: Although type 1 von Willebrand disease (VWD) is the most common bleeding disorder seen by pediatric hematologists, making a definitive diagnosis continues to be a challenge in clinical practice. Both the International Society on Thrombosis and Haemostasis (ISTH) and the Hospital for Sick Children in Toronto (HSC) have proposed diagnostic criteria for type 1 VWD. These include abnormal laboratory values, significant mucocutaneous bleeding, and/or a positive family history. Most recently, the ISTH published updated recommendations, which differed only in the requirement of more abnormal laboratory results (VWF:Ag 5–20 IU/ml). We applied ISTH and HSC criteria, as well as updated ISTH criteria, to a large population of pediatric patients diagnosed with type 1 VWD. We hypothesized that a substantial number of patients would not meet either HSC or ISTH diagnostic criteria. Methods: We performed a retrospective medical record review of all type 1 VWD patients at our Hemostasis and Thrombosis Center. We evaluated each record for bleeding history, family history, and laboratory values. Frequencies of fit for HSC, ISTH and updated ISTH criteria were calculated. Mean VWF:Ag, VWF:RCo, and bleeding scores (Rodeghiero et al, J Thromb Haemost, 2006) were compared across populations meeting each proposed criteria. Results: Of 201 patients, 33.9% met the HSC definition of “definitive” type 1 VWD, 4.5% met ISTH definition, and 0% met updated ISTH definition. An additional 56.2% (HSC), 15.4% (ISTH), and 6% (updated ISTH) met definitions of “possible” type 1 VWD. For each proposed definition, criteria for significant mucocutaneous bleeding were most likely to be met, while criteria for abnormal laboratory values were least likely. In fact, 74% of patients had significant bleeding as defined by the HSC (56% as defined by ISTH). We did find significant clinical and laboratory differences between patients labeled as definite, possible, and normal by ISTH and HSC criteria. For example, patients meeting criteria for definite disease by HSC criteria had a mean bleeding score of 3.5 and mean VWF:Ag of 31 IU/ml, compared to 2.6 and 47 IU/ml in patients labeled as possible, and 2.2 and 68 IU/ml in patients labeled as normal (p=0.001 bleeding score, <0.001 mean VWF:Ag). Regardless of whether they met any set of criteria, most patients (94%) received some type of medical intervention (pre-operative or therapeutic desmopressin or VWF replacement). Discussion: We found that the majority of our pediatric type 1 VWD patients did not meet the original ISTH definition of definite or even possible type 1 VWD, thus confirming in a larger population the findings of HSC investigators (Dean et al, Thromb Haemost, 2000). In addition, we have demonstrated that the new ISTH criteria are even more inappropriate for clinical practice in a pediatric population, with 0% of patients meeting criteria for definite disease. Therefore, these criteria failed to identify a substantial number of children and adolescents who presented to medical attention, had significant mucocutaneous bleeding, and required therapeutic interventions. The new ISTH criteria may be an excellent scientific tool for identifying a narrow, severely affected population of patients likely to have autosomal dominant VWD mutations. However, they do not appear to have clinical validity in the pediatric setting.

Resolution of superficial necrolytic dermatitis following excision of a glucagon-secreting pancreatic neoplasm in a dog

1997 ◽  
Vol 33 (4) ◽  
pp. 313-319 ◽  
Author(s):  
SM Torres ◽  
DD Caywood ◽  
TD O'Brien ◽  
TP O'Leary ◽  
PJ McKeever
Keyword(s):  
Pancreatic Islet ◽  
Complete Resolution ◽  
Pancreatic Neoplasm ◽  
Skin Lesions ◽  
Laboratory Analysis ◽  
Tumor Excision ◽  
Abnormal Laboratory ◽  
Standard Poodle ◽  
Clinically Normal ◽  
Laboratory Values

An 11-year-old, neutered male standard poodle was diagnosed with superficial necrolytic dermatitis and a glucagon-secreting pancreatic islet neoplasm based on clinical, biochemical, histopathological, immunohistochemical, and hormonal findings. Hyperglucagonemia, hyperinsulinemia, and hypoaminoacidemia were observed on preoperative laboratory analysis. Abnormal laboratory values returned to normal, and complete resolution of skin lesions occurred after tumor excision. The dog has remained clinically normal for six months following surgery.

scholarly journals Associations between hyponatraemia, volume depletion and the risk of falls in US hospitalised patients: a case–control study

BMJ Open ◽  
2017 ◽  
Vol 7 (8) ◽  
pp. e017045 ◽  
Author(s):  
Elizabeth A Fehlberg ◽  
Robert J Lucero ◽  
Michael T Weaver ◽  
Anna M McDaniel ◽  
A Michelle Chandler ◽  
...  
Keyword(s):  
Serum Sodium ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Volume Depletion ◽  
Abnormal Laboratory ◽  
Laboratory Values ◽  
Hospitalised Patients ◽  
Hospital Acquired ◽  
Control Study

ObjectiveWe aimed to determine if abnormal laboratory values which may indicate volume depletion are associated with increased odds of experiencing a hospital-acquired fall.DesignMatched case–control study.SettingFour hospitals located in the Southeast USA.ParticipantsData from 699 adult fallers and 1189 matched controls (non-fallers) were collected via chart review from 2005 to 2010. Controls were matched to cases by nursing unit, time of fall and length of stay.Outcome measuresThe primary exposures included serum sodium, blood urea nitrogen (BUN), creatinine, BUN/creatinine ratio and haematocrit. Conditional logistic regression with m:n matching was used to determine adjusted and unadjusted ORs.ResultsSerum sodium levels were strongly associated with falls. In models controlling for demographic and other fall risk factors, patients with serum sodium levels of 125 mEq/L or less were associated with increased odds of experiencing a fall as compared with those with serum sodium levels of greater than 134 mEq/L (adjusted OR (aOR)=5.08, 95% CI 1.43 to 18.08). Conversely, elevated BUN, creatinine and elevated BUN/creatinine ratios were not associated with increased odds of experiencing a fall (aOR=0.64, 95% CI 0.49 to 0.84; aOR=0.70, 95% CI 0.54 to 0.92 and aOR=0.77, 95% CI 0.58 to 1.04, respectively.)ConclusionsLaboratory indices that may indicate volume depletion appear to be unrelated to falls. However, hyponatraemia does appear to be a risk factor for falls, and those with serum sodium levels below 126 mEq/L are at especially high risk. It may be that other deficits associated with hyponatraemia, like altered mental status, are associated with risk of experiencing a hospital-acquired fall. These results indicate that abnormal laboratory values, like low sodium, can be useful for identifying hospitalised patients at risk of falling. Therefore, further investigation into abnormal laboratory values as predictors of hospital-acquired falls is warranted.

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