scholarly journals Effects of paroxetine-mediated inhibition of GRK2 expression on depression and cardiovascular function in patients with myocardial infarction

2016 ◽  
Vol Volume 12 ◽  
pp. 2333-2341 ◽  
Author(s):  
Xiuqing Tian ◽  
Qing Wang ◽  
Rui Guo ◽  
Lingling Xu ◽  
Qin Chen ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Function ◽  
Grk2 Expression

scholarly journals APPLICATION OF WAVE INTENSITY AND ECHO-TRACKING TO EVALUATE CARDIOVASCULAR FUNCTION CHANGES IN PATIENTS WITH MYOCARDIAL INFARCTION

Heart ◽  
2012 ◽  
Vol 98 (Suppl 2) ◽  
pp. E283.4-E284 ◽  
Author(s):  
Yong Xu ◽  
Jun-song Liu ◽  
Guang Zhi ◽  
Jing Wang ◽  
Shu-lin Ou ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Function ◽  
Wave Intensity ◽  
Echo Tracking

In situ delivery of bone marrow cells and mesenchymal stem cells improves cardiovascular function in hypertensive rats submitted to myocardial infarction

2008 ◽  
Vol 15 (3) ◽  
pp. 365-374 ◽  
Author(s):  
Luisa Maria Gomes de Macedo Braga ◽  
Silvia Lacchini ◽  
Beatriz D’Agord Schaan ◽  
Bruno Rodrigues ◽  
Kaleizu Rosa ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Bone Marrow Cells ◽  
Cardiovascular Function ◽  
Hypertensive Rats ◽  
Marrow Cells

scholarly journals Myofilament calcium sensitization delays decompensated hypertrophy differently between the sexes following myocardial infarction

2011 ◽  
Vol 300 (2) ◽  
pp. R361-R368 ◽  
Author(s):  
Krystyna M. Shioura ◽  
Mariam Farjah ◽  
David L. Geenen ◽  
R. John Solaro ◽  
Paul H. Goldspink
Keyword(s):  
Myocardial Infarction ◽  
Transgenic Mice ◽  
Troponin I ◽  
Contractile Function ◽  
Cardiac Contractility ◽  
Cardiovascular Function ◽  
Diagnostic Value ◽  
Initial Increase ◽  
Vascular Response ◽  
The Impact

Contractile dysfunction is common to many forms of cardiovascular disease. Approaches directed at enhancing cardiac contractility at the level of the myofilaments during heart failure (HF) may provide a means to improve overall cardiovascular function. We are interested in gender-based differences in cardiac function and the effect of sarcomere activation agents that increase contractility. Thus, we studied the effect of gender and time on integrated arterial-ventricular function (A-V relationship) following myocardial infarction (MI). In addition, transgenic mice that overexpress the slow skeletal troponin I isoform were used to determine the impact of increased myofilament Ca2+ sensitivity following MI. Based on pressure-volume (P-V) loop measurements, we used derived parameters of cardiovascular function to reveal the effects of sex, time, and increased myofilament Ca2+ sensitivity among groups of post-MI mice. Analysis of the A-V relationship revealed that the initial increase was similar between the sexes, but the vascular unloading of the heart served to delay the decompensated stage in females. Conversely, the vascular response at 6 and 10 wk post-MI in males contributed to the continuous decline in cardiovascular function. Increasing the myofilament Ca2+ sensitivity appeared to provide sufficient contractile support to improve contractile function in both male and female transgenic mice. However, the improved contractile function was more beneficial in males as the concurrent vascular response contributed to a delayed decompensated stage in female transgenic mice post-MI. This study represents a quantitative approach to integrating the vascular-ventricular relationship to provide meaningful and diagnostic value following MI. Consequently, the data provide a basis for understanding how the A-V relationship is coupled between males and females and the enhanced ability of the cardiovascular system to tolerate pathophysiological stresses associated with HF in females.

CARDIOVASCULAR FUNCTION AND NEUROHUMORAL MANIFESTATIONS IN ACUTE MYOCARDIAL INFARCTION

Shock ◽  
1995 ◽  
Vol 4 (Supplement) ◽  
pp. 4
Author(s):  
Yoshihiko Seino ◽  
Hiroshi Tsukamoto ◽  
Shin-ichiro Shimai ◽  
Koichi Setsuta ◽  
Teruo Takano ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Cardiovascular Function
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