scholarly journals Effect of Jian-Pi-Zhi-Dong Decoction on striatal glutamate and γ-aminobutyric acid levels detected using microdialysis in a rat model of Tourette syndrome

2016 ◽  
pp. 1233 ◽  
Author(s):  
Wen Zhang ◽  
Li Wei ◽  
Wenjing Yu ◽  
Xia Cui ◽  
Xiaofang Liu ◽  
...  
Keyword(s):  
Tourette Syndrome ◽  
Rat Model ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid

scholarly journals Gamma-Aminobutyric Acid (GABA) and Sepsis-Related Encephalopathy

1988 ◽  
Vol 15 (1) ◽  
pp. 23-25 ◽  
Author(s):  
T.R. Winder ◽  
G.Y. Minuk ◽  
E.J. Sargeant ◽  
T.P. Seland
Keyword(s):  
Rat Model ◽  
Brain Cortex ◽  
Cecal Ligation ◽  
Elevated Serum ◽  
Clinical Signs ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Bacterial Sepsis ◽  
Gaba Content ◽  
The Brain

ABSTRACT:In order to determine whether disturbances in GABA homeostasis might play a role in the pathogenesis of sepsis-related encephalopathy, serum and brain tissue GABA concentrations from six areas of the brain (cortex, diencephalon, striatum, hippocampus, midbrain, and pons-medulla) were determined in a rat model of bacterial sepsis (cecal ligation and perforation). The results were compared to those obtained from sham operated control animals. All septic animals demonstrated clinical signs of encephalopathy and had elevated serum GABA levels (0.92 ± 0.3 uM versus 0.48 ± 0.15 in controls, p < 0.01). GABA content in the specific subcompartments of the brain, however, were similar in the two groups. These results indicate that although serum GABA levels are elevated during sepsis, GABA is unlikely to play an important role in the pathogenesis of sepsis-related encephalopathy.

scholarly journals Effect of “Jian-Pi-Zhi-Dong Decoction” on Gamma-Aminobutyric Acid in a Mouse Model of Tourette Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Wen Zhang ◽  
Wenjing Yu ◽  
Daohan Wang ◽  
Li Wei ◽  
Minkyoung Lee ◽  
...  
Keyword(s):  
Mouse Model ◽  
Mrna Expression ◽  
Tourette Syndrome ◽  
Real Time Pcr ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Mice Model ◽  
Positive Effects ◽  
Gaba Metabolism ◽  
Abnormal Behaviors

The purpose of this study was to explore the positive effects of Jian-Pi-Zhi-Dong Decoction (JPZDD) on Tourette syndrome (TS) by investigating the expression of gamma-aminobutyric acid (GABA) and its type A receptor (GABAAR) in the striatum of a TS mice model. The model was induced by 3,3′-iminodipropionitrile (IDPN) treatment; then mice were divided into 4 groups (n=22, each); control and IDPN groups were gavaged with saline and the remaining 2 groups were gavaged with tiapride and JPZDD. We recorded the stereotypic behaviors of TS mice and measured the content of GABA in striatum by HPLC and GABAAR expression by immunohistochemistry and real-time PCR. Our results showed that JPZDD inhibited the abnormal behaviors of TS model mice and decreased GABA levels and GABAAR protein and mRNA expression in the striatum of TS model mice. In brief, the mechanism by which JPZDD alleviates TS symptoms may be associated with GABAAR expression downregulation in striatum which may regulate GABA metabolism.

Successive alterations of hippocampal gamma-aminobutyric acid B receptor subunits in a rat model of febrile seizure

Life Sciences ◽  
2006 ◽  
Vol 78 (25) ◽  
pp. 2944-2952 ◽  
Author(s):  
Ying Han ◽  
Jiong Qin ◽  
Ding-Fang Bu ◽  
Xing-Zhi Chang ◽  
Zhi-Xian Yang
Keyword(s):  
Rat Model ◽  
Febrile Seizure ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid

Gamma-aminobutyric acid (GABAA) receptor-function in a rat model of hepatic encephalopathy

1990 ◽  
Vol 5 (4) ◽  
pp. 185-193 ◽  
Author(s):  
Bennie L. Baker ◽  
A. Leslie Morrow ◽  
John Vergalla ◽  
Steven M. Paul ◽  
E. Anthony Jones
Keyword(s):  
Hepatic Encephalopathy ◽  
Gabaa Receptor ◽  
Rat Model ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Receptor Function
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