scholarly journals Matrix metalloproteinase-9 in the pathophysiology and diagnosis of dry eye syndrome

2017 ◽  
Vol Volume 4 ◽  
pp. 37-46 ◽  
Author(s):  
Stephen Pflugfelder ◽  
Bian Fang ◽  
Cintia De Paiva
Keyword(s):  
Matrix Metalloproteinase ◽  
Dry Eye ◽  
Matrix Metalloproteinase 9 ◽  
Dry Eye Syndrome ◽  
Metalloproteinase 9

A Highly Soluble Matrix Metalloproteinase-9 Inhibitor for Potential Treatment of Dry Eye Syndrome

2012 ◽  
pp. n/a-n/a
Author(s):  
Mattia Mori ◽  
Emanuele De Lorenzo ◽  
Eugenio Torre ◽  
Marco Fragai ◽  
Cristina Nativi ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Dry Eye ◽  
Matrix Metalloproteinase 9 ◽  
Dry Eye Syndrome ◽  
Potential Treatment ◽  
Metalloproteinase 9

scholarly journals Dry Eye Profiles in Patients with a Positive Elevated Surface Matrix Metalloproteinase 9 Point-of-Care Test Versus Negative Patients

2016 ◽  
Vol 14 (2) ◽  
pp. 216-223 ◽  
Author(s):  
Nicole L. Lanza ◽  
Allison L. McClellan ◽  
Hatim Batawi ◽  
Elizabeth R. Felix ◽  
Konstantinos D. Sarantopoulos ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Dry Eye ◽  
Point Of Care ◽  
Matrix Metalloproteinase 9 ◽  
Point Of Care Test ◽  
Elevated Surface ◽  
Metalloproteinase 9

scholarly journals Role of Matrix Metalloproteinase-9 in Diagnosis of Dry Eye

2020 ◽  
Vol 88 (9) ◽  
pp. 1761-1765
Author(s):  
AYMAN A. GAAFAR, M.D.; MOHAMED O. YOUSIF, M.D. ◽  
BASSEM F. AZIZ, M.D.; NARDEEN ADEL YACOUB, M.Sc.
Keyword(s):  
Matrix Metalloproteinase ◽  
Dry Eye ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9

scholarly journals Association of tear matrix metalloproteinase 9 immunoassay with signs and symptoms of dry eye disease: A cross-sectional study using qualitative, semiquantitative, and quantitative strategies

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258203
Author(s):  
You Hyun Lee ◽  
Seung-Pil Bang ◽  
Kyu-Young Shim ◽  
Myung-Jin Son ◽  
Harim Kim ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Dry Eye ◽  
Signs And Symptoms ◽  
Cross Sectional Study ◽  
Matrix Metalloproteinase 9 ◽  
Sectional Study ◽  
Cross Sectional ◽  
Staining Score ◽  
Corneal Staining ◽  
Metalloproteinase 9

Purpose This study aimed to analyze the association of tear matrix metalloproteinase 9 (MMP-9) immunoassay with the severity of dry eye (DE) signs and symptoms through qualitative, semiquantitative, and quantitative evaluations of immunoassay band. Materials and methods This cross-sectional study enrolled 320 eyes of 320 patients. The clinical signs of DE were assessed using the Ocular Surface Disorder Index (OSDI) score, visual analogue scale (VAS), tear breakup time (tBUT), tear volume evaluation by tear meniscometry, and staining scores of the cornea and conjunctiva by the Oxford grading scheme. The tear MMP-9 immunoassay results were interpreted using qualitative (positive or negative), semi-quantitative (reagent band density on a four-point scale: 0 = negative; 1 = weakly positive; 2 = moderately positive; 3 = strongly positive), and quantitative (ratio of reagent band density to control band density) indicators. Results Positive MMP-9 immunoassay results were significantly related to shorter tBUT, tBUT ≤3 seconds, higher corneal staining score, corneal staining score ≥2, and conjunctival staining score ≥2. The semi-quantitative results of the MMP-9 immunoassay were positively correlated with higher corneal staining score (r = 0.122, p = 0.029) and negatively correlated with tBUT (r = -0.125, p = 0.025). However, in the quantitative analysis, none of the DE signs or symptoms were correlated to the band density of the MMP-9 immunoassay. Conclusions The positive MMP-9 immunoassay results were related to the severity of ocular signs of DE. However, using quantitative measures of the MMP-9 immunoassay to assess the clinical severity of DE requires further investigation.

scholarly journals Matrix Metalloproteinase-9 Knockout Confers Resistance to Corneal Epithelial Barrier Disruption in Experimental Dry Eye

2005 ◽  
Vol 166 (1) ◽  
pp. 61-71 ◽  
Author(s):  
Stephen C. Pflugfelder ◽  
William Farley ◽  
Lihui Luo ◽  
Lucy Zhuo Chen ◽  
Cintia S. de Paiva ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Dry Eye ◽  
Matrix Metalloproteinase 9 ◽  
Epithelial Barrier ◽  
Corneal Epithelial ◽  
Barrier Disruption ◽  
Metalloproteinase 9

Matrix Metalloproteinase 9 Testing in Dry Eye Disease Using a Commercially Available Point-of-Care Immunoassay

Ophthalmology ◽  
2016 ◽  
Vol 123 (11) ◽  
pp. 2300-2308 ◽  
Author(s):  
Elisabeth M. Messmer ◽  
Victoria von Lindenfels ◽  
Alexandra Garbe ◽  
Anselm Kampik
Keyword(s):  
Matrix Metalloproteinase ◽  
Dry Eye ◽  
Point Of Care ◽  
Matrix Metalloproteinase 9 ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Metalloproteinase 9

Matrix Metalloproteinase 9 and Transglutaminase 2 Expression at the Ocular Surface in Patients with Different Forms of Dry Eye Disease

Ophthalmology ◽  
2015 ◽  
Vol 122 (1) ◽  
pp. 62-71 ◽  
Author(s):  
Pasquale Aragona ◽  
M'Hammed Aguennouz ◽  
Laura Rania ◽  
Elisa Postorino ◽  
Margherita Serena Sommario ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Dry Eye ◽  
Ocular Surface ◽  
Transglutaminase 2 ◽  
Matrix Metalloproteinase 9 ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Metalloproteinase 9
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