scholarly journals The Difference Between Set and Delivered Tidal Volume: A Lung Simulation Study

2020 ◽  
Vol Volume 13 ◽  
pp. 205-211
Author(s):  
Yoshikazu Yamaguchi ◽  
Tetsuya Miyashita ◽  
Yuko Matsuda ◽  
Makoto Sasaki ◽  
Shunsuke Takaki ◽  
...  
Keyword(s):  
Tidal Volume ◽  
Simulation Study ◽  
The Difference ◽  
Lung Simulation

The Shikani HME: A New Tracheostomy Heat and Moisture Exchanger

2020 ◽  
Vol 63 (9) ◽  
pp. 2921-2929
Author(s):  
Alan H. Shikani ◽  
Elamin M. Elamin ◽  
Andrew C. Miller
Keyword(s):  
Ex Vivo ◽  
Moisture Loss ◽  
Speaking Valve ◽  
Time Zero ◽  
In Series ◽  
Turbulent Airflow ◽  
The Difference ◽  
Loss Efficiency ◽  
Heat And Moisture ◽  
Lung Simulation

Purpose Tracheostomy patients face many adversities including loss of phonation and essential airway functions including air filtering, warming, and humidification. Heat and moisture exchangers (HMEs) facilitate humidification and filtering of inspired air. The Shikani HME (S-HME) is a novel turbulent airflow HME that may be used in-line with the Shikani Speaking Valve (SSV), allowing for uniquely preserved phonation during humidification. The aims of this study were to (a) compare the airflow resistance ( R airflow ) and humidification efficiency of the S-HME and the Mallinckrodt Tracheolife II tracheostomy HME (M-HME) when dry (time zero) and wet (after 24 hr) and (b) determine if in-line application of the S-HME with a tracheostomy speaking valve significantly increases R airflow over a tracheostomy speaking valve alone (whether SSV or Passy Muir Valve [PMV]). Method A prospective observational ex vivo study was conducted using a pneumotachometer lung simulation unit to measure airflow ( Q ) amplitude and R airflow , as indicated by a pressure drop ( P Drop ) across the device (S-HME, M-HME, SSV + S-HME, and PMV). Additionally, P Drop was studied for the S-HME and M-HME when dry at time zero (T 0 ) and after 24 hr of moisture testing (T 24 ) at Q of 0.5, 1, and 1.5 L/s. Results R airflow was significantly less for the S-HME than M-HME (T 0 and T 24 ). R airflow of the SSV + S-HME in series did not significant increase R airflow over the SSV or PMV alone. Moisture loss efficiency trended toward greater efficiency for the S-HME; however, the difference was not statistically significant. Conclusions The turbulent flow S-HME provides heat and moisture exchange with similar or greater efficacy than the widely used laminar airflow M-HME, but with significantly lower resistance. The S-HME also allows the innovative advantage of in-line use with the SSV, hence allowing concurrent humidification and phonation during application, without having to manipulate either device.

Dynamic mechanisms determine functional residual capacity in mice, Mus musculus

1979 ◽  
Vol 46 (5) ◽  
pp. 867-871 ◽  
Author(s):  
A. Vinegar ◽  
E. E. Sinnett ◽  
D. E. Leith
Keyword(s):  
Tidal Volume ◽  
Functional Residual Capacity ◽  
Flow Volume ◽  
Linear Portion ◽  
Volume Curve ◽  
Flow Volume Curve ◽  
Residual Capacity ◽  
Expiratory Flow ◽  
The Difference ◽  
Pentobarbital Sodium Anesthesia

Awake mice (22.6--32.6 g) were anesthetized intravenously during head-out body plethysmography. One minute after pentobarbital sodium anesthesia, tidal volume had fallen from 0.28 +/- 0.04 to 0.14 +/- 0.02 ml and frequency from 181 +/- 20 to 142 +/- 8. Functional residual capacity (FRC) decreased by 0.10 +/- 0.02 ml. Expiratory flow-volume curves were linear, highly repeatable, and submaximal over substantial portions of expiration in awake and anesthetized mice; and expiration was interrupted at substantial flows that abruptly fell to and crossed zero as inspiration interrupted relaxed expiration. FRC is maintained at a higher level in awake mice due to a higher tidal volume and frequency coupled with expiratory braking (persistent inspiratory muscle activity or increased glottal resistance). In anesthetized mice, the absence of braking, coupled with reductions in tidal volume and frequency and a prolonged expiratory period, leads to FRCs that approach relaxation volume (Vr). An equation in derived to express the difference between FRC and Vr in terms of the portion of tidal volume expired without braking, the slope of the linear portion of the expiratory flow-volume curve expressed as V/V, the time fraction of one respiratory cycle spent in unbraked expiration, and respiratory frequency.

Decreased Carbon Dioxide Sensitivity in Infants of Substance-Abusing Mothers

PEDIATRICS ◽  
1995 ◽  
Vol 95 (6) ◽  
pp. 864-867
Author(s):  
Janet G. Wingkun ◽  
Janet S. Knisely ◽  
Sidney H. Schnoll ◽  
Gary R. Gutcher
Keyword(s):  
Carbon Dioxide ◽  
Tidal Volume ◽  
Minute Ventilation ◽  
Demographic Data ◽  
Substance Abusing ◽  
Quiet Sleep ◽  
Co2 Level ◽  
The Difference ◽  
End Tidal ◽  
Drug Free

Objective. To determine whether there is a demonstrable abnormality in control of breathing in infants of substance-abusing mothers during the first few days of life. Methods. We enrolled 12 drug-free control infants and 12 infants of substance abusing mothers (ISAMs). These infants experienced otherwise uncomplicated term pregnancies and deliveries. The infants were assigned to a group based on the results of maternal histories and maternal and infant urine toxicology screens. Studies were performed during quiet sleep during the first few days of life. We measured heart rate, oxygen saturations via a pulse oximeter, end-tidal carbon dioxide (ET-CO2) level, respiratory rate, tidal volume, and airflow. The chemoreceptor response was assessed by measuring minute ventilation and the ET-CO2 level after 5 minutes of breathing either room air or 4% carbon dioxide. Results. The gestational ages by obstetrical dating and examination of the infants were not different, although birth weights and birth lengths were lower in the group of ISAMs. Other demographic data were not different, and there were no differences in the infants' median ages at the time of study or in maternal use of tobacco and alcohol. The two groups had comparable baseline (room air) ET-CO2 levels, respiratory rates, tidal volumes, and minute ventilation. When compared with the group of ISAMs, the drug-free group had markedly increased tidal volume and minute ventilation on exposure to 4% carbon dioxide. These increases accounted for the difference in sensitivity to carbon dioxide, calculated as the change in minute ventilation per unit change in ET-CO2 (milliliters per kg/min per mm Hg). The sensitivity to carbon dioxide of control infants was 48.66 ± 7.14 (mean ± SE), whereas that of ISAMs was 16.28 ± 3.14. Conclusions. These data suggest that ISAMs are relatively insensitive to challenge by carbon dioxide during the first few days of life. We speculate that this reflects an impairment of the chemoreceptor response.

Anthropometric and other factors affecting respiratory responses to carbon dioxide in New Guineans

1974 ◽  
Vol 268 (893) ◽  
pp. 363-373 ◽  
Keyword(s):  
Linear Regression ◽  
Tidal Volume ◽  
Vital Capacity ◽  
Breathing Pattern ◽  
Respiratory Control ◽  
Control Mechanisms ◽  
Men And Women ◽  
Factors Affecting ◽  
Residual Difference ◽  
The Difference

A CO 2 rebreathing test was used to determine the breathing pattern and the ventilatory response to CO 2 in 15 Caucasians and 140 New Guineans (coastal and highland men and women, and male highlanders on the coast). The breathing pattern was analysed in terms of the slope and intercept ( M and K ) of the linear regression of ventilation on tidal volume: V e = M ( V t — K ), and of the interpolated tidal volume at a ventilation of 30 1 min-1 (V t,30 ). Each of these parameters bears a common relation to vital capacity throughout the groups studied. The CO 2 response was analysed in terms of the slope and intercept ( S and B ) of the linear regression of ventilation on P CO 2 : V e = S ( P CO 2 — B ). B is lower in women than in men. S is a function of vital capacity, and this relation accounts for the difference in CO 2 sensitivity between men and women, and for part of the difference between the resident highland and coastal groups; part is attributable to altitude-adaptation and disappears on migration. In all these respects, New Guineans resemble Caucasians, and the results demonstrate the importance of the size of the vital capacity in influencing the setting of the respiratory control mechanisms. In addition, there is a residual difference between the ethnic groups, with the New Guineans having the lower CO 2 sensitivities and thus a greater tolerance of CO 2 loads.

Simulation Study for the Series Connected Bundles of Microtubular SOFCs

2010 ◽  
Vol 7 (5) ◽  
Author(s):  
Yoshihiro Funahashi ◽  
Toru Shimamori ◽  
Toshio Suzuki ◽  
Yoshinobu Fujishiro ◽  
Masanobu Awano ◽  
...  
Keyword(s):  
Temperature Distribution ◽  
Solid Oxide Fuel Cells ◽  
Simulation Study ◽  
Energy Conversion Efficiency ◽  
Total Output ◽  
Fabrication Technology ◽  
Power Generators ◽  
Current Collection ◽  
The Difference ◽  
Bundle Structure

Solid oxide fuel cells (SOFCs) have the highest energy conversion efficiency among various power generators and expected to be earlier commercialization. Our study aims to develop fabrication techniques of microtubular SOFC bundles and establish realistic bundle structure for kilowatt class module. So far, we have succeeded to establish fabrication technology of the microtubular SOFC bundles using porous supporting matrices. In this study, the simulation study of the microtubular SOFC bundle was carried out to understand Joule heat and temperature distribution in the microtubular SOFC bundle during operation. The results indicated that the method of current collection had to be carefully considered, since the total output power loss of the bundle was estimated to be 27.8%. The temperature distribution of the bundle using porous MgO matrices turned out to be moderate compared with that in the previous bundle using porous (La,Sr)(Co,Fe)O3 matrices due to the difference in the thermal conductivity of each matrix constitute.

In vivo dimensional response of airways of different size to transpulmonary pressure

1975 ◽  
Vol 39 (1) ◽  
pp. 23-29 ◽  
Author(s):  
G. M. Tisi ◽  
V. D. Minh ◽  
P. J. Friedman
Keyword(s):  
Tidal Volume ◽  
Total Lung Capacity ◽  
Transpulmonary Pressure ◽  
Main Stem ◽  
Peripheral Airways ◽  
Lung Capacity ◽  
Linear Plot ◽  
The Difference ◽  
Lateral Roentgenograms

We studied four supine dogs that were anesthetized with pentobarbital, intubated, and ventilated with a piston pump. The dimensional response of central (CAW) (greater than 2 mm diam) and peripheral airways (PAW) (smaller than 2 mm diam) to changes in transpulmonary pressure (Ptp) was determined by progressive increments in tidal volume (VT). A specially designed electronics relay circuit permitted this relationship to be obtained for points of no flow during tidal volume breathing: i.e., preinspiration (FRC); end inspiration (FRC + VT). The airways were dusted with powdered tantalum. Six airway divisions were identified: four CAW: trachea, main stem, lobar, segmental; and two PAW: subsegmental, and lobular. AP and lateral roentgenograms were obtained by standard technics and primary magnification (mag factor 2). Airway diameters were plotted as a function of transpulmonary pressure between 3 and 26 cmH2O with the diameter at total lung capacity expressed as 100%. The data show that: 1) there is significant distensibility above 5 cmH2O for all airways from the trachea to the lobular airways; 2) that the pressure-diameter plot is a linear plot for each airway from 3 to 26 cmH2O with R values between 0.846 and 0.957; 3) the peripheral lobular airways are more distensible than the central airways (P smaller than 0.05). We attribute the difference in distensibility of the peripheral lobular airways to their lack of cartilaginous support, and their decreased muscular support when compared to the CAW.

Respiratory dead space and arterial to end-tidal CO2 tension difference in anesthetized man

1960 ◽  
Vol 15 (3) ◽  
pp. 383-389 ◽  
Author(s):  
J. F. Nunn ◽  
D. W. Hill
Keyword(s):  
Tidal Volume ◽  
Dead Space ◽  
Artificial Respiration ◽  
Physiological Dead Space ◽  
Anatomical Dead Space ◽  
The Subject ◽  
The Mean ◽  
The Difference ◽  
End Tidal ◽  
End Tidal Co2

Observations were made during both spontaneous and artificial respiration on 12 fit patients anesthetized for routine surgical procedures. Above a tidal volume of 350 ml (BTPS), the anatomical dead space was close to the predicted normal value for the subject. Below 350 ml, it was reduced in proportion to the tidal volume. The physiological dead space (below the carina) approximated to 0.3 times the tidal volume for tidal volumes between 163 and 652 ml (BTPS). Throughout the range the physiological dead space was considerably in excess of the anatomical dead space measured simultaneously. The difference (alveolar dead space) varied from 15 to 231 ml, being roughly proportional to the tidal volume. The mean arterial to end-tidal CO2 tension difference was 4.6 (S.D. ±2.5) mm Hg and not related to tidal volume or arterial CO2 tension. None of the findings appeared to depend on whether the respiration was spontaneous or artificial. Submitted on September 25, 1959

scholarly journals Comparison Between Two Multinomial Overdispersion Models Through Simulation

2020 ◽  
Vol 68 (1) ◽  
pp. 45-48
Author(s):  
Farzana Afroz ◽  
Zillur Rahman Shabuz
Keyword(s):  
Mixture Model ◽  
Simulation Study ◽  
Multinomial Distribution ◽  
Finite Mixture Model ◽  
Finite Mixture ◽  
Multinomial Model ◽  
Pollen Data ◽  
Multinomial Data ◽  
The Difference ◽  
Overdispersion Parameter

A key assumption when using the multinomial distribution is that the observations are independent. In many practical situations, the observations could be correlated or clustered and the probabilities within each cluster might vary, which may lead to overdispersion. In this paper we discuss two well-known approaches to model overdispersed multinomial data, the Dirichlet-multinomial model and the finite-mixture model. The difference between these two models has been illustrated via simulation study. The forest pollen data is considered as a practical example of overdisperse multinomial data. The overdispersion parameter,φ, has been estimated using two classical estimators. Dhaka Univ. J. Sci. 68(1): 45-48, 2020 (January)

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