Novel concept of detecting basal cell carcinoma in skin tissue using a continuous-wave millimeter-wave rectangular glass filled probe

Diffuse reflectance spectrum as a noninvasive method has been widely used to study the optical properties of cutaneous skin tissue. In this work, we optimized an eight-layered optical model of basal cell carcinoma skin tissue to study its optical properties. Based on the model, the diffuse reflectance spectra were reconstructed in visible wavelength range by Monte Carlo methods. After different blood contents were added to the optical model, the contribution of blood to diffuese reflectance spectra was investigated theoretically. The ratios of basal cell carcinoma skin and normal skin tissue were also calculated for both experimental result and rebuilt results to testify the theoretical reasonability of the model and methods.

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Discrimination between basal cell carcinoma and hair follicles in skin tissue sections by Raman micro-spectroscopy

Journal of Molecular Structure ◽

10.1016/j.molstruc.2010.10.046 ◽

2011 ◽

Vol 993 (1-3) ◽

pp. 57-61 ◽

Cited By ~ 20

Author(s):

M. Larraona-Puy ◽

A. Ghita ◽

A. Zoladek ◽

W. Perkins ◽

S. Varma ◽

...

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Hair Follicles ◽

Skin Tissue ◽

Tissue Sections

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Erythropoetin and Erythropoetin Receptor Systems, and Oxidative Status in Patients with Basal Cell Carcinoma

Folia Medica ◽

10.3897/folmed.63.e54969 ◽

2021 ◽

Vol 63 (4) ◽

pp. 475-480

Author(s):

Ergul Belge Kurutas ◽

Perihan Ozturk

Keyword(s):

Oxidative Stress ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Skin Tissue ◽

Main Function ◽

Oxidative Stress Biomarkers ◽

Dermatology Clinic ◽

Oxidative Condition

Introduction: Erythropoietin (Epo) controls a variety of signal transduction pathways during oxidative stress. The main function of Epo and its receptor (EpoR) is the stimulation of erythropoiesis.  Aim: The role of Epo and EpoR on non-hematopoietic normal and cancerous tissues is still poorly understood. This is the first report in which we aimed to investigate the role of Epo and EpoR systems at oxidative condition in human basal cell carcinoma (BCC), which is the most common tumour in the world.Materials and methods: Fresh normal and cancerous skin paired tissue was obtained from 63 patients who underwent curative BCC resection in Kahramanmaras, Turkey. Preliminary diagnosis of BCC was made in the dermatology clinic by excision and then the diagnosis was confirmed as histopathologic findings. Oxidative stress biomarkers such as superoxide dismutase (SOD) and catalase (CAT) activities, and malondialdehyde (MDA) levels in biopsy samples were measured spectrophotometrically, and also the levels of Epo and EpoR were measured by ELISA.  Results: While the levels of MDA in cancerous tissue of patients with skin BCC were significantly higher than normal neighbouring skin tissue (p<0.05), SOD and CAT activities decreased (p<0.05). Furthermore, a remarkable increase was found in the Epo level ofpatients with skin BCC in comparison with the normal neighbouring skin tissue (p<0.05). However, we found that EpoR levelsdecreased (p<0.05).  Conclusions: Results indicate that there is an active oxidative process in BCC biopsies. The levels of increased Epo and decreased EpoR in oxidative condition due to hypoxia may aggravate tumour growth by its angiogenic activity.

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Laser-Induced Fluorescence and Reflectance Spectroscopy for the Discrimination of Basal Cell Carcinoma from the Surrounding Normal Skin Tissue

Skin Pharmacology and Physiology ◽

10.1159/000211912 ◽

2009 ◽

Vol 22 (3) ◽

pp. 158-165 ◽

Cited By ~ 21

Author(s):

E. Drakaki ◽

E. Kaselouris ◽

M. Makropoulou ◽

A.A. Serafetinides ◽

A. Tsenga ◽

...

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Normal Skin ◽

Reflectance Spectroscopy ◽

Laser Induced Fluorescence ◽

Skin Tissue

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Ultrastructure of Mouse Basal Cell Carcinoma Exhibiting Sebaceous Differentiation

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s1431927600003214 ◽

1980 ◽

Vol 38 ◽

pp. 738-739

Author(s):

Victoria L. Wade ◽

Winslow G. Sheldon ◽

James W. Townsend ◽

William Allaben

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Topical Application ◽

Basal Cell ◽

Sebaceous Gland ◽

Rats And Mice ◽

Mixed Tumors

Sebaceous gland tumors and other tumors exhibiting sebaceous differentiation have been described in humans (1,2,3). Tumors of the sebaceous gland can be induced in rats and mice following topical application of carcinogens (4), but spontaneous mixed tumors of basal cell origin rarely occur in mice.

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