scholarly journals TLR4 Antagonism Reduces Movement-Induced Nociception and ATF-3 Expression in Experimental Osteoarthritis

2021 ◽  
Vol Volume 14 ◽  
pp. 2615-2627
Author(s):  
Joana Ferreira-Gomes ◽  
Miguel M Garcia ◽  
Diana Nascimento ◽  
Lígia Almeida ◽  
Ernesto Quesada ◽  
...  
Keyword(s):  
Experimental Osteoarthritis

The Gut Microbiota of Rats under Experimental Osteoarthritis and Administration of Chondroitin Sulfate and Probiotic

2020 ◽  
Vol 82 (6) ◽  
pp. 64-73
Author(s):  
O.H. Korotkyi ◽  
◽  
T.V. Luhovska ◽  
T.M. Serhiychuk ◽  
K.O. Dvorshchenko ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Chondroitin Sulfate ◽  
Joint Inflammation ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Quantitative Composition ◽  
Combined Administration ◽  
Osteoarthritis Progression ◽  
Experimental Osteoarthritis ◽  
Gut Microbiota Composition

Osteoarthritis is a most widespread chronic degenerative joint disease that causes pain, cartilage deformation, and joint inflammation. Adverse alterations of intestinal microbiota like dysbiosis may lead to metabolic syndrome and inflammation, two important components of osteoarthritis progression. Aim. In this study we investigated the effect of chondroitin sulfate and probiotics on the gut microbiome in monoiodoacetate-induced osteoarthritis model in rats. Methods. The species and quantitative composition of feces were determined using diagnostic media with selective properties. Further identification of isolated microorganisms was carried out according to morphological, tinctorial, physiological and metabolic parameters. The results are presented in the form of lg CFU/g. Results. Induction of osteoarthritis caused significant increasing the number of opportunistic enterobacteria and lactose-negative Escherichia coli against the decreasing of lacto- and bifidobacteria that may indicate a dysbiotic condition. Coadministration of chondroitin sulfate and probiotic bacteria has led to improvement the quantitative composition of the gut microbiota in experimental animals, the numerous of Bifidobacterium, Lactobacillus were increasing against decreasing the quantitative composition of opportunistic microorganisms. Conclusions. Monoiodoacetate-induced osteoarthritis caused dysbiosis of gut in rat. We observed beneficial effect of combined administration of chondroitin sulfate and probiotics on gut microbiota composition in rats with experimental osteoarthritis. Thus, adding of supplements like probiotics to standard treatment of osteoarthritis may have potentials to prevent and treat this disease.

Dynamics of Interleukin-1β and Inducible NO-Synthase Activities in Blood of Rats in Experimental Osteoarthritis

2019 ◽  
Vol 4 (5) ◽  
pp. 78-84
Author(s):  
І. V. Savytskyi ◽  
◽  
К. S. Orel ◽  
І. V. Miastkivska ◽  
V. І. Savytskyi ◽  
...  
Keyword(s):  
No Synthase ◽  
Interleukin 1Β ◽  
Inducible No Synthase ◽  
Experimental Osteoarthritis

scholarly journals Suppression of experimental osteoarthritis by adenovirus-mediated double gene transfer

2006 ◽  
Vol 119 (16) ◽  
pp. 1365-1373 ◽  
Author(s):  
Hai-jun WANG ◽  
Chang-long YU ◽  
Hiroyuki Kishi ◽  
Kazumi Motoki ◽  
Ze-bin MAO ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Experimental Osteoarthritis

scholarly journals Sympathectomy as well as β2-adrenoceptor deficiency lead to exacerbation of subchondral bone changes in experimental osteoarthritis

Bone Reports ◽  
2021 ◽  
Vol 14 ◽  
pp. 101042
Author(s):  
Gundula Rösch ◽  
Dominique Muschter ◽  
Karima El Bagdadi ◽  
Shahed Taheri ◽  
Andrea Meurer ◽  
...  
Keyword(s):  
Subchondral Bone ◽  
Bone Changes ◽  
Experimental Osteoarthritis

Accentuated transdermal application of glucosamine sulphate attenuates experimental osteoarthritis induced by monosodium iodoacetate

2016 ◽  
Vol 4 (25) ◽  
pp. 4470-4481 ◽  
Author(s):  
Helen Chattopadhyay ◽  
Biswajit Auddy ◽  
Tapas Sur ◽  
Santanu Sana ◽  
Sriparna Datta
Keyword(s):  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Transdermal Application ◽  
Monosodium Iodoacetate ◽  
Glucosamine Sulphate ◽  
Experimental Osteoarthritis

Osteoarthritis is a chronic degenerative joint disease causing pain and disability.

scholarly journals Experimental Osteoarthritis in the Rabbit

1985 ◽  
Vol 26 (3) ◽  
pp. 313-325
Author(s):  
Eiliv Svalastoga ◽  
Inge Reimann
Keyword(s):  
Experimental Osteoarthritis
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