scholarly journals Derivation of a Risk Assessment Tool for Prediction of Long-Term Pain Intensity Reduction After Physical Therapy

2021 ◽  
Vol Volume 14 ◽  
pp. 1515-1524
Author(s):  
Maggie E Horn ◽  
Steven Z George ◽  
Cai Li ◽  
Sheng Luo ◽  
Trevor A Lentz
Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 3511-3511 ◽  
Author(s):  
Nikhil Mukhi ◽  
Gurinder Sidhu ◽  
Christopher Nabors ◽  
Chaitanya Iragavarapu

Abstract Introduction: VTE is the third most common cause of hospital related deaths and the most common preventable cause of hospital death. Population based studies have continually emphasized the rising prevalence of VTE. As per data from CDC, VTE complicated about 550,000 hospitalizations each year in adults >18yrs. The prevalence was much higher in adults >60yrs and female sex. Pulmonary embolism accounts for about 5-10% of hospital deaths and the case fatality rates of DVT ranges between 1-10% mainly due to fatal PE and is highest in those with malignancies. VTE is associated with long term risks of post thrombotic syndrome and chronic thromboembolic pulmonary hypertension which contributes significantly to patient morbidity and cost of management. The ENDORSE trial assessed the proportion of at-risk medical patients who received thromboprophylaxis and determined that 39.5% (6119 out of 15487 patients) received ACCP-recommended VTE prophylaxis. The most effective strategies to improve prophylaxis consist of a system for reminding clinicians to assess patients for VTE risk, either electronic decision-support systems or paper-based reminders. In a recent study electronic VTE risk assessment tool (elVis) on VTE prophylaxis in hospitalised patients improved the prophylaxis rates by 5.0% amongst all patients and by 10.7% amongst high risk patients. Materials and Methods: This was a retrospective study to assess the effectiveness of a VTE (Venous Thrombo Embolism) risk assessment tool as part of the in hospital quality control initiative. A total of 400 charts were reviewed; 200 prior to implementation of the risk assessment tool, and 200 after. Patients with incomplete or missing data were excluded. A total of 388 patients were included in the study (Fig 1). These patients were randomly picked in the pre and post implementation phases of the study (April 2011 and October 2011 respectively). The hospital committee designed the risk assessment tool based on the ACCP guidelines with few modifications individualized to our patient population. The tool was an automatic and mandatory pop op that would guide the admitting resident in making a decision about VTE prophylaxis. After the tool was implemented (July 2011), all house staff were educated on its use by a dedicated lecture during a noon conference session. Results: Demographics and results of the study are shown via the following table: Table 1.Pre-VTE toolPost-VTE toolNumber of patients189199Male47.9%49.7%Moderate –High Risk57.1%61.3%Individual Risk FactorsPrior VTE13.7%15.7%Chronic Pulm Disease17.9%19.1%Chronic Heart Failure14.4%16.9%Long term immobility11.7%17.4%Obesity37.2%34.3%Thrombophilia1.2%1.1%Malignancy4.6%4.7%Contraindications to anticoagulation19.04%19.06%Treatment Correctness56.3%80.3% Conclusions: This study gives us insight that VTE risk assessment tool accompanied with staff education improves VTE prophylaxis in at risk medicine inpatients. Study also confirms that incorporation of VTE prophylaxis guidelines in routine clinical practice can be assisted by electronic assessment and decision support tools. Disclosures No relevant conflicts of interest to declare.


2020 ◽  
Author(s):  
Diego C. Nascimento ◽  
Pedro L. Ramos ◽  
Oilson A. Gonzatto ◽  
Gabriel G. Ferreira ◽  
Patricia P. M. de Castro ◽  
...  

Cure fraction is not an easy task to be calculated relating probabilistic estimations to an event. For instance, cancer patients may abandon treatment, be cured, or die due to another illness, causing limitations regarding the information about the odds of cancer cure (related to the patient follow-up) and may mislead the researcher's inference. In this paper, we overcame this limitation and proposed a risk assessment tool related to the lifetime of cancer patients to survival functions to help medical decision-making. Moreover, we proposed a new machine learning algorithm, so-called long-term generalized weighted Lindley (LGWL) distribution, solving the inferential limitation caused by the censored information. Regarding the robustness of this distribution, some mathematical properties are shown and inferential procedures discussed, under the maximum likelihood estimators' perspective. Empirical results used TCGA lung cancer data (but not limited to this cancer type) showing the competitiveness of the proposed distribution to the medical field. The cure-rate is dynamic but quantifiable. For instance, after 14 years of development/spread of lung cancer, the group of patients under the age of 70 had a cure fraction of 32%, while the group of elderly patients presented a cure fraction of 22%, whereas those estimations using the traditional (long-term) Weibull distribution is 31% and 17%. The LGWL returned closer curves to the empirical distribution, then were better adjusted to the adopted data, elucidating the importance of cure-rate fraction in survival models.


Sign in / Sign up

Export Citation Format

Share Document