scholarly journals Estrogen Regulation of the Expression of Pain Factor NGF in Rat Chondrocytes

2021 ◽  
Vol Volume 14 ◽  
pp. 931-940
Author(s):  
Xiushuai Shang ◽  
Liaoran Zhang ◽  
Rilong Jin ◽  
Hu Yang ◽  
Hairong Tao
Keyword(s):  
Estrogen Regulation

Expression and estrogen regulation of brain-derived neurotrophic factor gene and protein in the forebrain of female prairie voles

2001 ◽  
Vol 433 (4) ◽  
pp. 499-514 ◽  
Author(s):  
Yan Liu ◽  
Christie D. Fowler ◽  
Larry J. Young ◽  
Qiao Yan ◽  
Thomas R. Insel ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Prairie Voles ◽  
Estrogen Regulation ◽  
Factor Gene

scholarly journals Lipin1 Regulation by Estrogen in Uterus and Liver: Implications for Diabetes and Fertility

Endocrinology ◽  
2007 ◽  
Vol 148 (8) ◽  
pp. 3685-3693 ◽  
Author(s):  
P. Mangala Gowri ◽  
Surojeet Sengupta ◽  
Suzanne Bertera ◽  
Benita S. Katzenellenbogen
Keyword(s):  
Metabolic Regulation ◽  
Energy Use ◽  
Nod Mice ◽  
Blood Levels ◽  
Estrogen Regulation ◽  
Nonobese Diabetic ◽  
Lipid Utilization ◽  
Phosphatidic Acid Phosphatase ◽  
Target Organs ◽  
Estrogen Administration

Estrogens are essential for fertility and also have important effects on regulation of adiposity and the euglycemic state. We report here that lipin1, a candidate gene for lipodystrophy and obesity that is a phosphatidic acid phosphatase critical in regulation of cellular levels of diacylglycerol and triacylglycerol and a key regulator of lipid utilization, is rapidly and robustly down-regulated in the uterus by estradiol via the estrogen receptor. Lipin1 is expressed predominantly in the uterine luminal and glandular epithelium, and during the estrous cycle, lipin1 is lowest when blood levels of estrogen are highest. Lipin1 is expressed throughout all cells in the liver of ovariectomized female mice, and a sustained down-regulation is observed at the mRNA, protein and immunohistochemical levels after estrogen administration. Because the coupling of proper energy use and availability is central to reproduction, we also investigated expression of lipin1 in the uterus and liver of several mouse models of diabetes. Nonobese diabetic (NOD) mice, which have high blood levels of estrogen and impaired fertility, were severely deficient in lipin1 in the uterus and liver, which, interestingly, could be restored by insulin treatment. By contrast, nonobese diabetic/severe combined immunodeficient (NOD-SCID) mice, which do not develop diabetes, showed normal levels of lipin1. Our findings of lipin1 regulation by estrogen in two key target organs suggest a new role for this lipid-regulating phosphatase not only in central metabolic regulation but also in uterine function and reproductive biology. Estrogen regulation of lipin1 may provide a mechanistic link between estrogens, lipid metabolism, and lipid signaling.

scholarly journals Progestin and estrogen regulation of pulsatile LH release and development of persistent ovarian follicles in cattle.

1996 ◽  
Vol 74 (6) ◽  
pp. 1424 ◽  
Author(s):  
J E Kinder ◽  
F N Kojima ◽  
E G Bergfeld ◽  
M E Wehrman ◽  
K E Fike
Keyword(s):  
Ovarian Follicles ◽  
Estrogen Regulation ◽  
Lh Release

scholarly journals Tissue-Specific Pathways for Estrogen Regulation of Ovarian Cancer Growth and Metastasis

2010 ◽  
Vol 70 (21) ◽  
pp. 8927-8936 ◽  
Author(s):  
Monique A. Spillman ◽  
Nicole G. Manning ◽  
Wendy W. Dye ◽  
Carol A. Sartorius ◽  
Miriam D. Post ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Growth ◽  
Estrogen Regulation ◽  
Tissue Specific
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