scholarly journals S100A4 in Spinal Substantia Gelatinosa from Dorsal Root Ganglia Modulates Neuropathic Pain in a Rodent Spinal Nerve Injury Model

2021 ◽  
Vol Volume 14 ◽  
pp. 665-679
Author(s):  
Xin Jiang ◽  
Wenqi Zhao ◽  
Tiantian Zhao ◽  
Mei Yang ◽  
Hongbin Yuan ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Nerve Injury ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Spinal Nerve ◽  
Substantia Gelatinosa ◽  
Injury Model

scholarly journals Upregulation of Casein Kinase 1∊ in Dorsal Root Ganglia and Spinal Cord after Mouse Spinal Nerve Injury Contributes to Neuropathic Pain

2009 ◽  
Vol 5 ◽  
pp. 1744-8069-5-74 ◽  
Author(s):  
Eri Sakurai ◽  
Takashi Kurihara ◽  
Kasumi Kouchi ◽  
Hironao Saegusa ◽  
Shuqin Zong ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Nerve Injury ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Spinal Nerve ◽  
Casein Kinase ◽  
Casein Kinase 1

The role of dorsal root ganglia PIM1 in peripheral nerve injury-induced neuropathic pain

2019 ◽  
Vol 709 ◽  
pp. 134375
Author(s):  
Yun Zou ◽  
Yumeng Cao ◽  
Yuqi Liu ◽  
Xinyi Zhang ◽  
Jinbao Li ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Peripheral Nerve ◽  
Nerve Injury ◽  
Dorsal Root Ganglia ◽  
Peripheral Nerve Injury ◽  
Dorsal Root

scholarly journals Metamizole relieves pain by influencing cytokine levels in dorsal root ganglia in a rat model of neuropathic pain

2020 ◽  
Vol 72 (5) ◽  
pp. 1310-1322
Author(s):  
Renata Zajaczkowska ◽  
Klaudia Kwiatkowski ◽  
Katarzyna Pawlik ◽  
Anna Piotrowska ◽  
Ewelina Rojewska ◽  
...  
Keyword(s):  
Nervous System ◽  
Neuropathic Pain ◽  
Sciatic Nerve ◽  
Nerve Injury ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Pain Treatment ◽  
Opioid Analgesic ◽  
Intraperitoneal Administration ◽  
Pain Symptoms

Abstract Background Treatment of neuropathic pain is still challenging. Recent studies have suggested that dorsal root ganglia (DRG), which carry sensory neural signals from the peripheral nervous system to the central nervous system, are important for pathological nociception. A proper understanding of the significance and function of DRG and their role in pharmacotherapy can help to improve the treatment of neuropathic pain. Metamizole, also known as sulpyrine or dipyrone, is a non-opioid analgesic commonly used in clinical practice, but it is not used for neuropathic pain treatment. Methods Chronic constriction injury (CCI) of the sciatic nerve was induced in Wistar rats. Metamizole was administered intraperitoneally (ip) preemptively at 16 and 1 h before CCI and then twice a day for 7 days. To evaluate tactile and thermal hypersensitivity, von Frey and cold plate tests were conducted, respectively. Results Our behavioral results provide evidence that repeated intraperitoneal administration of metamizole diminishes the development of neuropathic pain symptoms in rats. Simultaneously, our findings provide evidence that metamizole diminishes the expression of pronociceptive interleukins (IL-1beta, IL-6, and IL-18) and chemokines (CCL2, CCL4, and CCL7) in DRG measured 7 days after sciatic nerve injury. These assays indicate, for the first time, that metamizole exerts antinociceptive effects on nerve injury-induced neuropathic pain at the DRG level. Conclusions Finally, we indicate that metamizole-induced analgesia in neuropathy is associated with silencing of a broad spectrum of cytokines in DRG. Our results also suggest that metamizole is likely to be an effective medication for neuropathic pain. Graphic abstract

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