scholarly journals A Randomized, Crossover, Pharmacokinetic and Adhesion Performance Study of a Lidocaine Topical System 1.8% During Physical Activity and Heat Treatment in Healthy Subjects

2020 ◽  
Vol Volume 13 ◽  
pp. 1359-1367
Author(s):  
Jeffrey Fudin ◽  
Erica L Wegrzyn ◽  
Emileigh Greuber ◽  
Kip Vought ◽  
Kalpana Patel ◽  
...  
Keyword(s):  
Physical Activity ◽  
Heat Treatment ◽  
Healthy Subjects ◽  
Performance Study ◽  
Adhesion Performance

scholarly journals Open-Label Adhesion Performance Studies of a New Lidocaine Topical System 1.8% versus Lidocaine Patches 5% and Lidocaine Medicated Plaster 5% in Healthy Subjects

2021 ◽  
Vol Volume 14 ◽  
pp. 513-526
Author(s):  
Jeffrey Gudin ◽  
Lynn R Webster ◽  
Emileigh Greuber ◽  
Kip Vought ◽  
Kalpana Patel ◽  
...  
Keyword(s):  
Performance Studies ◽  
Healthy Subjects ◽  
Open Label ◽  
Adhesion Performance

scholarly journals Serum Neuregulin-1β as a Biomarker of Cardiovascular Fitness

2009 ◽  
Vol 2 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Vaibhav Moondra ◽  
Satyam Sarma ◽  
Tracy Buxton ◽  
Radwan Safa ◽  
Gregory Cote ◽  
...  
Keyword(s):  
Physical Activity ◽  
Skeletal Muscle ◽  
Healthy Subjects ◽  
Sandwich Elisa ◽  
Bicycle Ergometer ◽  
Cardiovascular Fitness ◽  
Elisa Assay ◽  
Healthy Men ◽  
Sandwich Elisa Assay ◽  
Cardio Respiratory Fitness

Purpose: Neuregulins (NRG) are growth factors that bind to receptors of the erbB family, and are known to mediate a number of processes involved in diverse tissues. Neuregulin-1β is expressed in skeletal muscle and is activated by exercise. We hypothesized that NRG-1β might circulate in the bloodstream and increase as a consequence of physical activity. A study was conducted in healthy subjects to determine if NRG-1β is immunodetectable in human serum, and if so whether levels relate acutely or chronically to exercise. Methods: Nine healthy men underwent three bouts of exercise of varying degrees of intensity on a bicycle ergometer over a period of three weeks. Cardio-respiratory fitness was determined by measurement of maximal oxygen uptake (VO2max). Serum was sampled prior to and immediately after each session (up to 30 minutes post) and serum NRG-1ß was quantified utilizing an indirect sandwich ELISA assay developed in our lab. Results: Across subjects, mean serum NRG-1β levels ranged from 32 ng/mL to 473 ng/mL. Individual subjects showed relatively stable levels during the study period that did not change acutely after exercise. Serum NRG-1β demonstrated a positive correlation with VO2max (r2=0.49, p =.044). Conclusions: These preliminary observations suggest that at least in healthy men, serum NRG-1β is an indicator of cardio- respiratory fitness and does not change acutely with exercise.

Physical Activity as a Moderator of Alzheimer Pathology: A Systematic Review of Observational Studies

2019 ◽  
Vol 16 (4) ◽  
pp. 362-378 ◽  
Author(s):  
Kristian Steen Frederiksen ◽  
Le Gjerum ◽  
Gunhild Waldemar ◽  
Steen Gregers Hasselbalch
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Healthy Subjects ◽  
Observational Studies ◽  
Hippocampal Volume ◽  
Csf Biomarkers ◽  
Amyloid Pet ◽  
The Relationship ◽  
Alzheimer Pathology

Introduction: Observational studies have found that physical activity is associated with a reduced risk of cognitive decline and dementia. Whether physical activity may also reduce the level of AD pathology, remains undetermined. Objective: To examine the relationship between physical activity and AD biomarkers (beta-amyloid1- 42, total tau and phosphorylated tau in CSF, amyloid PET, hippocampal atrophy on MRI and parietotemporal hypometabolism on brain 18F-FDG-PET). Methods: We carried out a systematic review of the observational studies of physical activity and AD biomarkers in healthy subjects, subjective cognitive complaints, mild cognitive impairment (MCI) and AD dementia. Results: We identified a total of 40 papers, which were eligible for inclusion. Thirty-four studies were conducted on healthy subjects, 3 on MCI and healthy subjects, 1 on MCI, and 2 on AD and healthy controls. Six studies reported on CSF biomarkers, 9 on amyloid PET, 29 on MRI and 4 on brain 18FFDG- PET. The majority of studies did not find a significant association between physical activity and AD biomarkers Conclusion: The quality of included studies with only a few longitudinal studies, limits the conclusions which may be drawn from the present findings especially regarding the biomarkers other than hippocampal volume. However, the majority of the identified studies did not find a significant association.

scholarly journals Epigenetic Modifications of theα-Synuclein Gene and Relative Protein Content Are Affected by Ageing and Physical Exercise in Blood from Healthy Subjects

2018 ◽  
Vol 2018 ◽  
pp. 1-16 ◽  
Author(s):  
Simona Daniele ◽  
Barbara Costa ◽  
Deborah Pietrobono ◽  
Chiara Giacomelli ◽  
Caterina Iofrida ◽  
...  
Keyword(s):  
Physical Activity ◽  
Physical Exercise ◽  
Epigenetic Regulation ◽  
Healthy Subjects ◽  
Dna Methyltransferase ◽  
Epigenetic Modification ◽  
Methylation Status ◽  
Peripheral Tissues ◽  
Beneficial Effects ◽  
Age Related

Epigenetic regulation may contribute to the beneficial effects of physical activity against age-related neurodegeneration. For example, epigenetic alterations of the gene encoding forα-synuclein (SNCA) have been widely explored in both brain and peripheral tissues of Parkinson’s disease samples. However, no data are currently available about the effects of physical exercise onSNCAepigenetic regulation in ageing healthy subjects. The present paper explored whether, in healthy individuals, age and physical activity are related to blood intron1-SNCA(SNCAI1) methylation, as well as further parameters linked to such epigenetic modification (total, oligomericα-synuclein and DNA methyltransferase concentrations in the blood). Here, theSNCAI1methylation status increased with ageing, and consistent with this result, lowα-synuclein levels were found in the blood. The direct relationship betweenSNCAI1methylation andα-synuclein levels was observed in samples characterized by bloodα-synuclein concentrations of 76.3 ng/mg protein or lower (confidence interval (CI) = 95%). In this selected population, higher physical activity reduced the total and oligomericα-synuclein levels. Taken together, our data shed light on ageing- and physical exercise-induced changes on theSNCAmethylation status and protein levels ofα-synuclein.

scholarly journals Variability of the perception of dyspnea in healthy subjects assessed through inspiratory resistive loading

2015 ◽  
Vol 41 (2) ◽  
pp. 143-150 ◽  
Author(s):  
Bruna Ziegler ◽  
Andréia Kist Fernandes ◽  
Paulo Roberto Stefani Sanches ◽  
Glauco Luís Konzen ◽  
Paulo de Tarso Roth Dalcin
Keyword(s):  
Physical Activity ◽  
Pulmonary Function ◽  
Healthy Subjects ◽  
Pulmonary Function Tests ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Long Form ◽  
Resistive Loading ◽  
Resistive Loads ◽  
Minute Walk

Objective: Few studies have evaluated the variability of the perception of dyspnea in healthy subjects. The objective of this study was to evaluate the variability of the perception of dyspnea in healthy subjects during breathing against increasing inspiratory resistive loads, as well as to assess the association between the level of perception of dyspnea and the level of physical activity. Methods: This was a cross-sectional study involving healthy individuals 16 years of age or older. Subjects underwent inspiratory resistive loading testing, in which the level of perception of dyspnea was quantified with the modified Borg scale. We also determined body mass indices (BMIs), assessed maximal respiratory pressures, performed pulmonary function tests, applied the international physical activity questionnaire (IPAQ)-long form, and conducted six-minute walk tests (6MWTs). The level of perception of dyspnea was classified as low (Borg score < 2), intermediate (Borg score, 2-5), or high (Borg score > 5). Results: We included 48 healthy subjects in the study. Forty-two subjects completed the test up to a load of 46.7 cmH2O/L/s. The level of perception of dyspnea was classified as low, intermediate, and high in 13, 19, and 10 subjects, respectively. The level of perception of dyspnea was not significantly associated with age, gender, BMI, IPAQ-long form score, maximal respiratory pressures, or pulmonary function test results. Conclusions: The scores for perceived dyspnea induced by inspiratory resistive loading in healthy subjects presented wide variability. The perception of dyspnea was classified as low in 31% of the subjects, intermediate in 45%, and high in 24%. There was no association between the level of perception of dyspnea and the level of physical activity (IPAQ or six-minute walk distance).

scholarly journals 321 PHYSICAL ACTIVITY PARAMETERS AND SELECTED DIETARY FACTORS ON CHOLESTEROL IN HEALTHY SUBJECTS

1993 ◽  
Vol 25 (Supplement) ◽  
pp. S58
Author(s):  
G. J. Gatzke ◽  
L. R. Brilla ◽  
T. A. Mazurek ◽  
C. Henderson
Keyword(s):  
Physical Activity ◽  
Healthy Subjects ◽  
Dietary Factors

The influence of physical activity and gender on vital exhaustion in healthy subjects

2015 ◽  
Vol 61 ◽  
pp. 76-77
Author(s):  
Anne-Katrin Puschmann ◽  
Kathrin Klipker ◽  
Anja Weiffen ◽  
Pia-Maria Wippert
Keyword(s):  
Physical Activity ◽  
Healthy Subjects ◽  
Vital Exhaustion ◽  
And Gender

Are Ultrasound Findings Similar in Patients with Axial Spondyloarthritis and in Athlete Entheses?

2017 ◽  
Vol 44 (5) ◽  
pp. 609-612 ◽  
Author(s):  
Marie-Alix Lanfranchi ◽  
Olivier Leluc ◽  
Alice Tavano ◽  
Cécile Wormser ◽  
Sophie Morange ◽  
...  
Keyword(s):  
Physical Activity ◽  
Healthy Subjects ◽  
Axial Spondyloarthritis ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Sectional Study ◽  
Control Groups ◽  
Cross Sectional ◽  
Ultrasound Findings ◽  
Us Findings

Objective.Enthesitis is the spondyloarthritis (SpA) landmark, but can also be seen after entheses overuse, such as during intensive sport.Methods.We aimed to compare entheses ultrasound (US) findings in a prospective cross-sectional study of 30 axial SpA cases, 30 athletes, and 29 controls.Results.Mean (SD) MAdrid Sonographic Enthesis Index (MASEI) score was 26.3 (13), 12.2 (7), and 10.4 (6) in patients with SpA, athletes, and non-athlete control groups, respectively (p < 0.0001).Conclusion.The MASEI score was significantly higher in patients with SpA compared with healthy controls, athletes, and non-athletes, and can be of value to distinguish SpA from healthy subjects, whatever their physical activity.

scholarly journals Peculiarities of Physical Activity and Self‑Esteem of Young People with Diabetes Mellitus Type 1 and Healthy Persons Aged 18–25 Years

2018 ◽  
Vol 4 (83) ◽  
Author(s):  
Sandrija Čapkauskienė ◽  
Daiva Vizbaraitė ◽  
Deimantė Šeštokaitė
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Healthy Subjects ◽  
Self Esteem ◽  
Diabetes Mellitus Type 1 ◽  
Diabetes Mellitus Type ◽  
Diabetic Patients ◽  
Patients With Diabetes ◽  
Healthy Persons

Research background and hypothesis. Careful diabetes control slows the onset and progression of life-threatening complications, the development of disability and early disability-related unemployment, and prolongs life expectancy (Danytė et al., 2000). The benefits of physical activity on regular basis comprise improved cardiovascular health, increased  lean body mass, improved  blood lipid profile, enhanced  psycho-social wellbeing and decreased obesity  (Riddell, Iscoe, 2006). Physical activity is one of the main factors influencing glucose level in diabetic patients’ blood (Wiśniewski, 2010). Analysis of self-esteem of the studied revealed a wide range of findings, from trying to outline the modest achievements, pride, and even unwillingness to discuss it to low self-esteem, feeling of guilt and self-reproach for mistakes and failures (Žemaitis, 1995). The aim of the study was to determine physical activity and self-esteem of healthy subjects and patients with diabetes mellitus type 1 aged 18–25 years.Methods. The  study  included  140  individuals  (aged  from  18  to  25  years). Among  41  patients  with  type  1 diabetes mellitus there were 33 young women and 8 young men, and among 99 healthy persons – 79 young women and  29 young men. All the subjects were asked to fill in the questionnaire orientated to physical activity and self-esteem. The short IPAQ questionnaire was used to research physical activity and Rosenberg’s Self-Esteem Scale was used to assess self esteem.Research results. Approximately 60% of subjects with  diabetes mellitus type 1 and about 50% of healthy persons rated their physical activity as moderate. Intensive 60-minute-physical activity was reported by 48.5% of healthy subjects and 34.1% of diabetic patients, moderate 60-minute-physical activity was pointed out by 38.2% of diabetic patients and 35.8% of healthy research participants. The largest walking interval was 1–1.5 hours: in the diabetic group– 28.8%, in the healthy group – 31.65%. Healthy young men and women were physically more active than diabetic patients. Self-esteem in both genders of healthy subjects and diabetic patients was determined as moderate.Discussion and conclusions. Physical activity of women and men with diabetes mellitus type 1 aged 18–25 years was valued as moderate, meanwhile physical activity in healthy persons – moderate or high. Self-esteem is moderate in both groups of patients with diabetes and healthy persons. Healthy men are more active than diabetic patients, similarly, women having diabetes mellitus type 1 are more physically passive than healthy ones. Both patients with diabetes mellitus type 1 and healthy individuals aged 18–25 reported moderate self-esteem.Keywords: diabetes mellitus type 1, physical activity, self-esteem.

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