scholarly journals Nimesulide inhibits protein kinase C epsilon and substance P in sensory neurons – comparison with paracetamol

2011 ◽  
pp. 177 ◽  
Author(s):  
Vittorio Vellani ◽  
Franchi ◽  
Prandini ◽  
Moretti ◽  
Pavesi ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Substance P ◽  
Sensory Neurons ◽  
Kinase C ◽  
Protein Kinase C Epsilon

scholarly journals Gabapentin Inhibits Protein Kinase C Epsilon Translocation in Cultured Sensory Neurons with Additive Effects When Coapplied with Paracetamol (Acetaminophen)

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Vittorio Vellani ◽  
Chiara Giacomoni
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Sensory Neurons ◽  
Mechanism Of Action ◽  
Anticonvulsant Drug ◽  
Peripheral Neurons ◽  
Prokineticin 2 ◽  
Kinase C ◽  
Protein Kinase C Epsilon ◽  
Combined Use

Gabapentin is a well-established anticonvulsant drug which is also effective for the treatment of neuropathic pain. Although the exact mechanism leading to relief of allodynia and hyperalgesia caused by neuropathy is not known, the blocking effect of gabapentin on voltage-dependent calcium channels has been proposed to be involved. In order to further evaluate its analgesic mechanisms, we tested the efficacy of gabapentin on protein kinase C epsilon (PKCε) translocation in cultured peripheral neurons isolated from rat dorsal root ganglia (DRGs). We found that gabapentin significantly reduced PKCεtranslocation induced by the pronociceptive peptides bradykinin and prokineticin 2, involved in both inflammatory and chronic pain. We recently showed that paracetamol (acetaminophen), a very commonly used analgesic drug, also produces inhibition of PKCε. We tested the effect of the combined use of paracetamol and gabapentin, and we found that the inhibition of translocation adds up. Our study provides a novel mechanism of action for gabapentin in sensory neurons and suggests a mechanism of action for the combined use of paracetamol and gabapentin, which has recently been shown to be effective, with a cumulative behavior, in the control of postoperative pain in human patients.

scholarly journals Valproic acid inhibits substance P-induced activation of protein kinase C epsilon and expression of the substance P receptor

2004 ◽  
Vol 86 (1) ◽  
pp. 69-76 ◽  
Author(s):  
Klaus Lieb ◽  
Yvonne Treffurth ◽  
Maike Hamke ◽  
Ravi Shankar Akundi ◽  
Matthias Von Kleinsorgen ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Substance P ◽  
Kinase C ◽  
Protein Kinase C Epsilon ◽  
Substance P Receptor

scholarly journals INHIBITION OF PROTEIN KINASE C EPSILON CAUSES CILIATED BOVINE BRONCHIAL CELL DETACHMENT

2006 ◽  
Vol 32 (8) ◽  
pp. 349-362 ◽  
Author(s):  
Rebecca E. Slager ◽  
Joseph H. Sisson ◽  
Jaqueline A. Pavlik ◽  
Jennifer K. Johnson ◽  
Jeremy R. Nicolarsen ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cell Detachment ◽  
Kinase C ◽  
Protein Kinase C Epsilon

Regulation of tumor invasion and metastasis in protein kinase C epsilon-transformed NIH3T3 fibroblasts

2002 ◽  
Vol 85 (4) ◽  
pp. 785-797 ◽  
Author(s):  
Souvenir D. Tachado ◽  
Mark W. Mayhew ◽  
Ginger G. Wescott ◽  
Tonia L. Foreman ◽  
Crystal D. Goodwin ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Tumor Invasion ◽  
Invasion And Metastasis ◽  
Kinase C ◽  
Protein Kinase C Epsilon

scholarly journals Design and synthesis of protein kinase C epsilon selective diacylglycerol lactones (DAG-lactones)

2015 ◽  
Vol 90 ◽  
pp. 332-341 ◽  
Author(s):  
Jihyae Ann ◽  
Suyoung Yoon ◽  
Jisoo Baek ◽  
Da Hye Kim ◽  
Nancy E. Lewin ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Design And Synthesis ◽  
Kinase C ◽  
Protein Kinase C Epsilon

scholarly journals Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance

2019 ◽  
Vol 29 (1) ◽  
pp. 183-191.e7 ◽  
Author(s):  
Amanda E. Brandon ◽  
Bing M. Liao ◽  
Barbara Diakanastasis ◽  
Benjamin L. Parker ◽  
Katy Raddatz ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Glucose Tolerance ◽  
Kinase C ◽  
Protein Kinase C Epsilon

scholarly journals Novel Small-Molecule Inhibitors of Protein Kinase C Epsilon Reduce Ethanol Consumption in Mice

2018 ◽  
Vol 84 (3) ◽  
pp. 193-201 ◽  
Author(s):  
Angelo Blasio ◽  
Jingyi Wang ◽  
Dan Wang ◽  
Florence P. Varodayan ◽  
Matthew B. Pomrenze ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Ethanol Consumption ◽  
Kinase C ◽  
Protein Kinase C Epsilon
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