scholarly journals Bayesian analysis of the effect of transcranial direct current stimulation on experimental pain sensitivity in older adults with knee osteoarthritis: randomized sham-controlled pilot clinical study

2018 ◽  
Vol Volume 11 ◽  
pp. 2071-2082 ◽  
Author(s):  
Hyochol Ahn ◽  
Robert Suchting ◽  
Adam J Woods ◽  
Hongyu Miao ◽  
Charles Green ◽  
...  
Keyword(s):  
Older Adults ◽  
Clinical Study ◽  
Knee Osteoarthritis ◽  
Bayesian Analysis ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Pain Sensitivity ◽  
Experimental Pain ◽  
Pilot Clinical Study ◽  
Experimental Pain Sensitivity

scholarly journals Vitamin D, race, and experimental pain sensitivity in older adults with knee osteoarthritis

2012 ◽  
Vol 64 (12) ◽  
pp. 3926-3935 ◽  
Author(s):  
T. L. Glover ◽  
B. R. Goodin ◽  
A. L. Horgas ◽  
L. L. Kindler ◽  
C. D. King ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Knee Osteoarthritis ◽  
Pain Sensitivity ◽  
Experimental Pain ◽  
Experimental Pain Sensitivity

scholarly journals The Effect of Transcranial Direct Current Stimulation on Inflammation in Older Adults With Knee Osteoarthritis: A Bayesian Residual Change Analysis

2019 ◽  
Vol 22 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Robert Suchting ◽  
Gabriela D. Colpo ◽  
Natalia P. Rocha ◽  
Hyochol Ahn
Keyword(s):  
Older Adults ◽  
Knee Osteoarthritis ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Preliminary Evidence ◽  
Analysis Of Covariance ◽  
Linear Modeling ◽  
Change Analysis ◽  
Direct Current Stimulation ◽  
Tnf Α

Transcranial direct current stimulation (tDCS) has demonstrated effectiveness in reducing clinical and experimental measures of pain in patients with chronic pain; however, research examining the mechanisms of action for the effects of tDCS has been lacking. The present study investigated the effect of active tDCS on measures of inflammation and stress. Older adults (aged 50–70 years) with knee osteoarthritis (OA) were randomly assigned to receive daily 20-min sessions of either tDCS ( n = 20) or sham tDCS ( n = 20) for 5 consecutive days. Participants provided blood samples at baseline and the end of treatment. The following measures of immune function and stress were collected: interleukin (IL)-6 and 10, tumor necrosis factor-α (TNF-α), C-reactive protein, cortisol, and β-endorphin. Generalized linear modeling evaluated each posttreatment measure as a function of tDCS group, controlling for baseline (measuring residual change, analogous to analysis of covariance). Bayesian statistical inference was used to directly quantify the probability of the effect of active tDCS. IL-6, IL-10, TNF-α, and β-endorphin demonstrated lower levels of stress and inflammation in the active tDCS group. These findings provide preliminary evidence that active (relative to sham) tDCS is associated with reduced levels of inflammation.

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