scholarly journals Optical inactivation of the anterior cingulate cortex modulate descending pain pathway in a rat model of trigeminal neuropathic pain created via chronic constriction injury of the infraorbital nerve

2017 ◽  
Vol Volume 10 ◽  
pp. 2355-2364 ◽  
Author(s):  
Hyeong Cheol Moon ◽  
Won Ik Heo ◽  
Yon Ji Kim ◽  
Daae Lee ◽  
So Yoon Won ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Anterior Cingulate Cortex ◽  
Rat Model ◽  
Chronic Constriction Injury ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Infraorbital Nerve ◽  
Trigeminal Neuropathic Pain ◽  
Pain Pathway

scholarly journals Strong Manual Acupuncture Stimulation of “Huantiao” (GB 30) Reduces Pain-Induced Anxiety and p-ERK in the Anterior Cingulate Cortex in a Rat Model of Neuropathic Pain

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Xiao-mei Shao ◽  
Zui Shen ◽  
Jing Sun ◽  
Fang Fang ◽  
Jun-fan Fang ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Anterior Cingulate Cortex ◽  
Rat Model ◽  
Cingulate Cortex ◽  
Spinal Nerve ◽  
Anterior Cingulate ◽  
Manual Acupuncture ◽  
Male Adult ◽  
Extracellular Signal ◽  
The Relationship

Persistent neuropathic pain is associated with anxiety. The phosphorylation of extracellular signal-regulated kinase (p-ERK) in the anterior cingulate cortex (ACC) plays an important role in pain-induced anxiety. Acupuncture is widely used for pain and anxiety. However, little is known about which acupuncture technique is optimal on pain-induced anxiety and the relationship between acupuncture effect and p-ERK. The rat model was induced by L5 spinal nerve ligation (SNL). Male adult SD rats were randomly divided into control, SNL, strong manual acupuncture (sMA), mild manual acupuncture (mMA), and electroacupuncture (EA) group. Bilateral “Huantiao” (GB 30) were stimulated by sMA, mMA, and EA, respectively. The pain withdrawal thresholds (PWTs) and anxiety behavior were measured, and p-ERK protein expression and immunoreactivity cells in ACC were detected. PWTs increased significantly in both sMA and EA groups. Meanwhile, anxiety-like behavior was improved significantly in the sMA and mMA groups. Furthermore, the overexpression of p-ERK induced by SNL was downregulated by strong and mild manual acupuncture. Therefore, strong manual acupuncture on bilateral “Huantiao” (GB 30) could be a proper therapy relieving both pain and pain-induced anxiety. The effect of different acupuncture techniques on pain-induced anxiety may arise from the regulation of p-ERK in ACC.

scholarly journals A transcriptomic analysis of neuropathic pain in the anterior cingulate cortex after nerve injury

Bioengineered ◽  
2022 ◽  
Vol 13 (2) ◽  
pp. 2058-2075
Author(s):  
Yu Zhang ◽  
Shiwei Jiang ◽  
Fei Liao ◽  
Zhifeng Huang ◽  
Xin Yang ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Anterior Cingulate Cortex ◽  
Nerve Injury ◽  
Cingulate Cortex ◽  
Transcriptomic Analysis ◽  
Anterior Cingulate

Author response: Insular and anterior cingulate cortex deep stimulation for central neuropathic pain: Disassembling the percept of pain

Neurology ◽  
2020 ◽  
Vol 94 (16) ◽  
pp. 721-722
Author(s):  
Daniel Ciampi de Andrade ◽  
Ricardo Galhardoni ◽  
Valquíria Aparecida da Silva ◽  
Luís García-Larrea ◽  
Camila Dale ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Author Response ◽  
Central Neuropathic Pain

Expression of muscarinic M1 and M2 receptors in the anterior cingulate cortex associated with neuropathic pain

2010 ◽  
Vol 14 (9) ◽  
pp. 901-910 ◽  
Author(s):  
J. Manuel Ortega-Legaspi ◽  
Martha León-Olea ◽  
Patricia de Gortari ◽  
María Isabel Amaya ◽  
Ulises Coffeen ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate

Sympathetic regulation and anterior cingulate cortex volume are altered in a rat model of chronic back pain

Neuroscience ◽  
2017 ◽  
Vol 352 ◽  
pp. 9-18 ◽  
Author(s):  
Sara Touj ◽  
Sébastien Houle ◽  
Djamel Ramla ◽  
Renaud Jeffrey-Gauthier ◽  
Harumi Hotta ◽  
...  
Keyword(s):  
Back Pain ◽  
Anterior Cingulate Cortex ◽  
Rat Model ◽  
Chronic Back Pain ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Sympathetic Regulation
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