scholarly journals Serotonin receptor agonists in the acute treatment of migraine: a review on their therapeutic potential

2018 ◽  
Vol Volume 11 ◽  
pp. 515-526 ◽  
Author(s):  
Andrea Negro ◽  
Angela Koverech ◽  
Paolo Martelletti
Keyword(s):  
Acute Treatment ◽  
Serotonin Receptor ◽  
Therapeutic Potential ◽  
Receptor Agonists ◽  
Serotonin Receptor Agonists

scholarly journals 5HT1A Serotonin Receptor Agonists Inhibit Plasmodium falciparum by Blocking a Membrane Channel

2003 ◽  
Vol 47 (12) ◽  
pp. 3806-3809 ◽  
Author(s):  
Christopher P. Locher ◽  
Peter C. Ruben ◽  
Jiri Gut ◽  
Philip J. Rosenthal
Keyword(s):  
Serotonin Receptor ◽  
Surface Membrane ◽  
Resistant Isolate ◽  
Neurological Involvement ◽  
Membrane Channel ◽  
Transport Pathway ◽  
Human Lung Fibroblast ◽  
Receptor Agonists ◽  
Serotonin Receptor Agonists

ABSTRACT Toidentify new leads for the treatment of Plasmodium falciparum malaria, we screened a panel of serotonin (5-hydroxytryptamine [5HT]) receptor agonists and antagonists and determined their effects on parasite growth. The 5HT1A receptor agonists 8-hydroxy-N-(di-n-propyl)-aminotetralin (8-OH-DPAT), 2,5-dimethoxy-4-iodoamphetamine, and 2,5-dimethoxy-4-bromophenylethylamine inhibited the growth of P. falciparum in vitro (50% inhibitory concentrations, 0.4, 0.7, and 1.5 μM, respectively). In further characterizing the antiparasitic effects of 8-OH-DPAT, we found that this serotonin receptor agonist did not affect the growth of Leishmania infantum, Trypanosoma cruzi, Trypanosoma brucei brucei, or Trichostrongylus colubriformis in vitro and did not demonstrate cytotoxicity against the human lung fibroblast cell line MRC-5. 8-OH-DPAT had similar levels of growth inhibition against several different P. falciparum isolates having distinct chemotherapeutic resistance phenotypes, and its antimalarial effect was additive when it was used in combination with chloroquine against a chloroquine-resistant isolate. In a patch clamp assay, 8-OH-DPAT blocked a P. falciparum surface membrane channel, suggesting that serotonin receptor agonists are a novel class of antimalarials that target a nutrient transport pathway. Since there may be neurological involvement with the use of 8-OH-DPAT and other serotonin receptor agonists in the treatment of falciparum malaria, new lead compounds derived from 8-OH-DPAT will need to be modified to prevent potential neurological side effects. Nevertheless, these results suggest that 8-OH-DPAT is a new lead compound with which to derive novel antimalarial agents and is a useful tool with which to characterize P. falciparum membrane channels.

Oral Serotonin Receptor Agonists

2005 ◽  
Vol 23 (3) ◽  
pp. 259-274 ◽  
Author(s):  
Jennifer H Lofland ◽  
David B Nash
Keyword(s):  
Serotonin Receptor ◽  
Receptor Agonists ◽  
Serotonin Receptor Agonists

scholarly journals Effects of 5-HT1A serotonin receptor agonists on parkinsonism

1999 ◽  
Vol 79 ◽  
pp. 43
Author(s):  
Masahiro Nomoto ◽  
Takao Shimizu ◽  
Shunsuke Tsujimura ◽  
Takeo Fukuda
Keyword(s):  
Serotonin Receptor ◽  
Receptor Agonists ◽  
Serotonin Receptor Agonists
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