scholarly journals A double-blind, randomized, comparative study of the use of a combination of uridine triphosphate trisodium, cytidine monophosphate disodium, and hydroxocobalamin, versus isolated treatment with hydroxocobalamin, in patients presenting with compressive neuralgias

2017 ◽  
Vol Volume 10 ◽  
pp. 397-404 ◽  
Author(s):  
Henrique Goldberg ◽  
Marco Antonio Mibielli ◽  
Carlos Pereira Nunes ◽  
Stephanie Wrobel Goldberg ◽  
Luiz Buchman ◽  
...  
Keyword(s):  
Comparative Study ◽  
Double Blind ◽  
Uridine Triphosphate ◽  
Cytidine Monophosphate

A double-blind comparative study of Trimethoprim-Polymyxin B versus Trimethoprim-Sulfacetamide-Polymyxin B otic solutions in the treatment of otorrhea

1981 ◽  
Vol 95 (3) ◽  
pp. 251-259 ◽  
Author(s):  
Maurice C. Gydé
Keyword(s):  
Comparative Study ◽  
Fungal Infection ◽  
Otitis Media ◽  
Randomized Study ◽  
Polymyxin B ◽  
Correction Method ◽  
Chi Square ◽  
Double Blind ◽  
Safety And Efficacy ◽  
Recurrent Otitis Media

AbstractThis was a double-blind randomized study to compare the safety and efficacy of timethoprim-polymyxin B (TP) and trimethoprim-sulfacetamide-polymyxin B (TSP) drops in the treatment of otorrhea. The 68 cases treated suffered from external otitis, recurrent otitis, recurrent otitis media with tympanic membrance perforation, or infected mastoid cavities and post-operative tympanoplasties. The TP ototopical solution was successful in 60·6 per cent of cases compared to 88·6 per cent of cases with TSP. These rates were statistically different using the Chi Square with Yates' correction method.There were no sings of ototoxicity, fungal infection overgrowth or local sensitivity to either of the solutions.The study has shown that both drugs are equally safe and that TSP is significantly more effective in the treatment of otorrhea.

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