scholarly journals Improving health-related quality of life through an evidence-based obesity reduction program: the Healthy Weights Initiative

2016 ◽  
pp. 103 ◽  
Author(s):  
Marla Rogers ◽  
Mark Lemstra
Keyword(s):  
Quality Of Life ◽  
Evidence Based ◽  
Health Related Quality ◽  
Reduction Program ◽  
Related Quality ◽  
Health Related

Standard Evidence-Based Pharmacological Treatment for OCD

2017 ◽  
Author(s):  
Jemma E Reid ◽  
Samar Reghunandanan ◽  
Ann Roberts ◽  
Naomi A Fineberg
Keyword(s):  
Quality Of Life ◽  
Pharmacological Treatment ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Evidence Based ◽  
Health Related Quality ◽  
Pharmacological Treatments ◽  
Related Quality ◽  
Health Related

This chapter reviews standard pharmacological treatments for OCD and the evidence supporting them. Selective serotonin reuptake inhibitors (SSRIs) remain the pharmacological treatment of choice and are associated with improved health-related quality of life. Improvements are usually sustained over time as long as treatment is continued. Discontinuation is associated with relapse and loss of quality of life, implying that treatment should continue long-term. A substantial minority of patients who fail to respond to SSRIs may benefit from dose elevation, switch to clomipramine, or adjunctive antipsychotic, though long-term trials validating the effectiveness and tolerability of these strategies are relatively lacking.

scholarly journals Postoperative Controls of ventilation tubes in children - by general practitioner or otolaryngologist? Study protocol for a multicenter randomized non-inferiority study (The ConVenTu study)

2020 ◽  
Author(s):  
Bjarne Austad ◽  
Ann Helen Nilsen ◽  
Anne-Sofie Helvik ◽  
Grethe Albrektsen ◽  
Ståle Nordgård ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Middle Ear ◽  
Otitis Media With Effusion ◽  
Evidence Based ◽  
Health Related Quality ◽  
Ventilation Tube ◽  
Related Quality ◽  
Ventilation Tubes ◽  
Health Related

Abstract Background: Otitis media with effusion is the major cause of acquired hearing problems in children. Some of the affected children need surgery with ventilation tubes in the tympanic membrane to reduce ear complaints and to improve hearing, middle ear function and health-related quality of life. This is one of the most common ambulatory surgeries performed on children. Postoperative controls are needed to assess that the tubes are functional, evaluate whether hearing loss has been improved, and to handle potential complications. The follow-up may continue for years and are usually done by otolaryngologists. Nevertheless: there exist no evidence-based guidelines concerning the level of expertise needed for postoperative controls of the ventilation tubes. The aim of this protocol is to describe the ConVenTu study that evaluates whether postoperative controls performed by general practitioners (GPs), represent a safe and sufficient alternative to controls performed by otolaryngologists. Methods/design: Multicenter randomized non-inferiority study conducted in clinical settings in seven hospitals located in Norway. Discharged children with ventilation tubes, aged 3-10 years are allocated randomly to receive postoperative controls by either an otolaryngologist at the hospital where they had ventilation tube surgery or their regular GP. Study participants are enrolled consecutively until 200 patients are included in each group. Two years after surgery we will compare pure tone average of hearing thresholds (primary endpoint) and middle ear function, complication rate, health-related quality of life and the parents’ evaluations of the postoperative care (secondary endpoints). Discussion: This protocol describes the first randomized non-inferiority study of GPs performing postoperative controls after surgery with ventilation tubes. Results from this study may be utilized for deriving evidence-based clinical practice guidelines of the level of postoperative controls after ventilation tube surgery which is safe and sufficient.

scholarly journals Neuromodulators in the Brain-Gut Axis: their Role in the Therapy of the Irritable Bowel Syndrome

2021 ◽  
Author(s):  
Mihaela Fadgyas Stanculete ◽  
Dan Lucian Dumitrascu ◽  
Douglas Drossman
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Evidence Based ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Irritable Bowel ◽  
The Brain ◽  
Rome Iv

Irritable bowel syndrome (IBS) is a clinically well-defined chronic condition that is now understood as a disorder of gut-brain regulation, as established in the work of the Rome IV committees coordinated by Drossman, 2016. People with IBS often report high disability levels and poor health-related quality of life. Drug therapy focuses on reducing main symptoms and disability and improving health-related quality of life. Central neuromodulators reduce IBS symptoms by targeting dysregulated pain and motility related to gut-brain dysregulation. It can also treat associated mental health symptoms. Based on their multiple effects on central and peripheral mechanisms, neuromodulators have been used to treat IBS patients. This review presents the rationale supporting medication treatments for specific IBS symptoms, discusses evidence-based management of IBS with central neuromodulators, and reviews the progress in the research for new neuromodulators.

scholarly journals Evidence-based Assessment of Health-related Quality of Life and Functional Impairment in Pediatric Psychology

2008 ◽  
Vol 33 (9) ◽  
pp. 983-996 ◽  
Author(s):  
Tonya M. Palermo ◽  
Anna C. Long ◽  
Amy S. Lewandowski ◽  
Dennis Drotar ◽  
Alexandra L. Quittner ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Functional Impairment ◽  
Pediatric Psychology ◽  
Evidence Based ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related
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