scholarly journals Comparisons of different mean airway pressure settings during high-frequency oscillation in inflammatory response to oleic acid-induced lung injury in rabbits

2009 ◽  
pp. 21
Author(s):  
Tomonobu Koizumi
Keyword(s):  
Oleic Acid ◽  
Lung Injury ◽  
Inflammatory Response ◽  
High Frequency ◽  
Airway Pressure ◽  
High Frequency Oscillation ◽  
Mean Airway Pressure ◽  
Frequency Oscillation

Optimal Mean Airway Pressure during High-frequency Oscillation

2001 ◽  
Vol 94 (5) ◽  
pp. 862-869 ◽  
Author(s):  
Sven Goddon ◽  
Yuji Fujino ◽  
Jonathan M. Hromi ◽  
Robert M. Kacmarek
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
High Frequency ◽  
Airway Pressure ◽  
Distress Syndrome ◽  
High Frequency Oscillation ◽  
Positive End Expiratory Pressure ◽  
Mean Airway Pressure ◽  
Frequency Oscillation ◽  
Initial Injury

Background A number of groups have recommended setting positive end-expiratory pressure during conventional mechanical ventilation in adults at 2 cm H2O above the lower corner pressure (P(CL)) of the inspiratory pressure-volume (P-V) curve of the respiratory system. No equivalent recommendations for the setting of the mean airway pressure (Paw) during high-frequency oscillation (HFO) exist. The authors questioned if the Paw resulting in the best oxygenation without hemodynamic compromise during HFO is related to the static P-V curve in a large animal model of acute respiratory distress syndrome. Methods Saline lung lavage was performed in seven sheep (28+/-5 kg, mean +/- SD) until the arterial oxygen partial pressure/fraction of inspired oxygen ratio decreased to 85+/-27 mmHg at a positive end-expiratory pressure of 5 cm H2O (initial injury). The PCL (20+/-1 cm H2O) on the inflation limb and the point of maximum curvature change (PMC; 26+/-1 cm H2O) on the deflation limb of the static P-V curve were determined. The sheep were subjected to four 1-h cycles of HFO at different levels of Paw (P(CL) + 2, + 6, + 10, + 14 cm H2O), applied in random order. Each cycle was preceded by a recruitment maneuver at a sustained Paw of 50 cm H2O for 60 s. Results High-frequency oscillation with a Paw of 6 cm H2O above P(CL) (P(CL) + 6) resulted in a significant improvement in oxygenation (P < 0.01 vs. initial injury). No further improvement in oxygenation was observed with higher Paw, but cardiac output decreased, pulmonary vascular resistance increased, and oxygen delivery decreased at Paw greater than P(CL) + 6. The PMC on the deflation limb of the P-V curve was equal to the P(CL) + 6 (r = 0.77, P < 0.05). Conclusion In this model of acute respiratory distress syndrome, optimal Paw during HFO is equal to P(CL) + 6, which correlates with the PMC.

A new system for ventilating with high-frequency oscillation

1982 ◽  
Vol 53 (6) ◽  
pp. 1638-1642 ◽  
Author(s):  
Y. K. Ngeow ◽  
W. Mitzner
Keyword(s):  
Tidal Volume ◽  
High Frequency ◽  
Airway Pressure ◽  
Ventilation System ◽  
High Frequency Oscillation ◽  
High Frequency Ventilation ◽  
Mean Airway Pressure ◽  
Frequency Oscillation ◽  
Frequency Ventilation ◽  
New System

We describe simple high-frequency oscillation systems that incorporate a CO2 absorber and supply O2 on a need basis. These systems have the advantage of easy control of mean airway pressure and airway hydration and negligible loss of oscillatory tidal volume. Experiments done at constant tidal volume showed that as frequency (and hence total ventilation) increased, arterial CO2 tension (PaCO2) decreased. The fall in PaCO2 occurred until frequency reached approximately 20 Hz; above 20 Hz further increases in frequency had little or no effect on PaCO2. Because of their practical advantages the techniques described here may be quite useful in a clinical setting where an oscillator, rather than jet-type high-frequency, ventilation system is desired.

EFFICACY OF HIGH FREQUENCY OSCILLATION IN OLEIC ACID-INDUCED SEVERE LUNG INJURY

1989 ◽  
Vol 71 (Supplement) ◽  
pp. A1192
Author(s):  
S. Sawamura ◽  
Y. Yamada ◽  
M. Suzukawa ◽  
T. Chinzei ◽  
K. Numata
Keyword(s):  
Oleic Acid ◽  
Lung Injury ◽  
High Frequency ◽  
High Frequency Oscillation ◽  
Frequency Oscillation ◽  
Severe Lung

scholarly journals NASAL HIGH FREQUENCY OSCILLATION AND NASAL CONTINUOUS POSITIVE AIRWAY PRESSURE FOR RESPIRATORY INSUFFIENCY IN NEWBORN INFANTS 1946

1996 ◽  
Vol 39 ◽  
pp. 327-327
Author(s):  
Eric G Brouwer ◽  
Mark A van der Hoeven ◽  
Danillo W Gavilanes ◽  
Pieter L Degraeuwe ◽  
Wiel J Maertzdort ◽  
...  
Keyword(s):  
Continuous Positive Airway Pressure ◽  
High Frequency ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Newborn Infants ◽  
High Frequency Oscillation ◽  
Frequency Oscillation
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