scholarly journals Long Non-Coding RNAs in Oral Submucous Fibrosis: Their Functional Mechanisms and Recent Research Progress

2021 ◽  
Vol Volume 14 ◽  
pp. 5787-5800
Author(s):  
Yaodong He ◽  
Wei Wang ◽  
Pingping Jiang ◽  
Lin Yang ◽  
Qi Guo ◽  
...  
Keyword(s):  
Oral Submucous Fibrosis ◽  
Research Progress ◽  
Submucous Fibrosis ◽  
Non Coding Rnas ◽  
Functional Mechanisms ◽  
Recent Research Progress

scholarly journals Molecular Mechanism of Oral Submucous Fibrosis induced by Arecoline: A Literature Review

2020 ◽  
Author(s):  
Lin Cui ◽  
Xinjia Cai ◽  
Junhui Huang ◽  
Huiling Li ◽  
Zhigang Yao
Keyword(s):  
Molecular Mechanism ◽  
Transforming Growth Factor ◽  
Oral Submucous Fibrosis ◽  
Transforming Growth Factor Β ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Research Progress ◽  
Areca Nut ◽  
Related Factors ◽  
Oral Potentially Malignant Disorders ◽  
Submucous Fibrosis

Oral Submucous Fibrosis (OSMF) is an oral mucosal disease with lamina propria collagen hyperplasia as the main pathological change, which belongs to Oral Potentially Malignant Disorders (OPMDs). Areca nut is identified as a class I carcinogen with complex components. Arecoline is the main component of areca nut which plays an important role in the pathogenesis of OSMF. Through the review of literature, it is shown that arecoline can lead to the change in level of cytokines in oral mucosa, which further leads to the imbalance of collagen metabolism. This article reviews the molecular mechanism research progress of arecoline in promoting the pathogenesis of OSMF in recent years, including Transforming Growth Factor-β (TGF-β) and Reactive Oxygen Species (ROS) associated with increased collagen production, Matrix Metalloproteinase (MMP) and Tissue Inhibitor of Metalloproteinase (TIMP) associated with reduced collagen degradation, hypoxia and microvascular related factors and in order to provide reference for the treatment of the disease at the molecular level.

scholarly journals Comparative Study of Intralesional Dexamethasone Plus Hyaluronidase & Oral Colchicine in Patients with Oral Submucous Fibrosis

2018 ◽  
Vol 14 (2) ◽  
pp. 60-65
Author(s):  
Ganesh Prasad Neupane ◽  
Maya Rai ◽  
R. S. Rathore ◽  
V. K. Bhargava ◽  
A. K. Mahat ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Oral Mucosa ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Study Groups ◽  
T Test ◽  
Significant Difference ◽  
Intralesional Injections ◽  
Submucous Fibrosis ◽  
Larger Sample

Introduction: Oral Submucous Fibrosis (OSMF) is a precancerous condition of the oral mucosa. It is characterized by excessive production of collagen leading to inelasticity of the oral mucosa and atrophic changes of the epithelium.Aim and objective: To evaluate the efficacy of oral Colchicine in comparison to intralesional injections of Dexamethasone plus Hyaluronidase in the management of OSMF patients.Materials and Methods: Fourty patients with OSMF were randomly divided equally into two groups. 20 patients in Dexamethasone group received biweekly intralesional injections of Dexamethasone (4mg/ml) plus Hyaluronidase 1500 IU in buccal mucosa for a period of 12 weeks. Other 20 patients in Colchicine group received oral Colchicine 0.5 mg tablets twice daily for 12 weeks. Parameters taken in the study were burning sensation, and mouth opening. Descriptive statistics, paired t test and unpaired t test were used for statistical analysis.Results and Conclusions: The pre- and post-treatment differences were found to be statistically significant for both the groups (p<0.001) and for both the treatment outcomes. When the average difference of the treatment outcomes was compared between the two study groups, statistically highly significant difference was noted (p <0.001) only in mouth opening but not in burning sensation.These encouraging results should prompt further clinical trials with Colchicine on a larger sample size to broaden the therapeutic usefulness of the drug in the management of OSMF. JNGMC,  Vol. 14 No. 2 December 2016, Page: 60-65

Localized peripheral autonomous neuropathy and dysfunctional myoepithelial cells: A novel hypothesis for xerostomia in oral submucous fibrosis

2020 ◽  
Vol 144 ◽  
pp. 109998
Author(s):  
Gargi S. Sarode ◽  
Sachin C. Sarode ◽  
Amol Gadbail ◽  
Shailesh Gondivkar ◽  
Shankargouda Patil
Keyword(s):  
Oral Submucous Fibrosis ◽  
Myoepithelial Cells ◽  
Submucous Fibrosis

Development and Validation of a Questionnaire to Evaluate Association of Tobacco Abuse With Oral Submucous Fibrosis

2011 ◽  
Vol 27 (2) ◽  
pp. NP132-NP142 ◽  
Author(s):  
Divya Mehrotra ◽  
Girdhar Gopal Agarwal ◽  
Sumit Kumar ◽  
Anand Shukla ◽  
Akash Asthana
Keyword(s):  
Oral Submucous Fibrosis ◽  
Tobacco Abuse ◽  
Submucous Fibrosis ◽  
Development And Validation

scholarly journals Conspicuous and frank dilated vascular spaces: A marker of malignant transformation in oral submucous fibrosis

2021 ◽  
Vol 11 (3) ◽  
pp. 365-367
Author(s):  
Sachin C. Sarode ◽  
Gargi S. Sarode ◽  
Namrata Sengupta ◽  
Urmi Ghone ◽  
Shankargouda Patil
Keyword(s):  
Malignant Transformation ◽  
Oral Submucous Fibrosis ◽  
Submucous Fibrosis

scholarly journals Targeting lncRNA H19/miR-29b/COL1A1 Axis Impedes Myofibroblast Activities of Precancerous Oral Submucous Fibrosis

2021 ◽  
Vol 22 (4) ◽  
pp. 2216
Author(s):  
Cheng-Chia Yu ◽  
Yi-Wen Liao ◽  
Pei-Ling Hsieh ◽  
Yu-Chao Chang
Keyword(s):  
Type I Collagen ◽  
Transforming Growth Factor ◽  
Smooth Muscle Actin ◽  
Oral Submucous Fibrosis ◽  
Ectopic Expression ◽  
Collagen Gel ◽  
Type I ◽  
Migration Ability ◽  
Potentially Malignant ◽  
Submucous Fibrosis

Oral submucous fibrosis (OSF) is known as a potentially malignant disorder, which may result from chemical irritation due to areca nuts (such as arecoline). Emerging evidence suggests that fibrogenesis and carcinogenesis are regulated by the interaction of long noncoding RNAs (lncRNAs) and microRNAs. Among these regulators, profibrotic lncRNA H19 has been found to be overexpressed in several fibrosis diseases. Here, we examined the expression of H19 in OSF specimens and its functional role in fibrotic buccal mucosal fibroblasts (fBMFs). Our results indicate that the aberrantly overexpressed H19 contributed to higher myofibroblast activities, such as collagen gel contractility and migration ability. We also demonstrated that H19 interacted with miR-29b, which suppressed the direct binding of miR-29b to the 3′-untranslated region of type I collagen (COL1A1). We showed that ectopic expression of miR-29b ameliorated various myofibroblast phenotypes and the expression of α-smooth muscle actin (α-SMA), COL1A1, and fibronectin (FN1) in fBMFs. In OSF tissues, we found that the expression of miR-29b was downregulated and there was a negative correlation between miR-29b and these fibrosis markers. Lastly, we demonstrate that arecoline stimulated the upregulation of H19 through the transforming growth factor (TGF)-β pathway. Altogether, this study suggests that increased TGF-β secretion following areca nut chewing may induce the upregulation of H19, which serves as a natural sponge for miR-29b and impedes its antifibrotic effects.

Sign in / Sign up

Export Citation Format

Share Document