scholarly journals Neuroinflammation and Microglial Activation at Rostral Ventrolateral Medulla Underpin Cadmium-Induced Cardiovascular Dysregulation in Rats

2021 ◽  
Vol Volume 14 ◽  
pp. 3863-3877
Author(s):  
Ching-Yi Tsai ◽  
Chi Fang ◽  
Jacqueline CC Wu ◽  
Chiung-Ju Wu ◽  
Kuang-Yu Dai ◽  
...  
Keyword(s):  
Microglial Activation ◽  
Rostral Ventrolateral Medulla ◽  
Ventrolateral Medulla

B�tzinger neurons project towards bulbospinal neurons in the rostral ventrolateral medulla of the rat

1997 ◽  
Vol 388 (1) ◽  
pp. 23-31 ◽  
Author(s):  
Qi-Jian Sun ◽  
Jane Minson ◽  
Ida J. Llewellyn-Smith ◽  
Leonard Arnolda ◽  
John Chalmers ◽  
...  
Keyword(s):  
Rostral Ventrolateral Medulla ◽  
Ventrolateral Medulla

Role of Nitric Oxide Synthase Uncoupling at Rostral Ventrolateral Medulla in Redox-Sensitive Hypertension Associated With Metabolic Syndrome

Hypertension ◽  
2014 ◽  
Vol 64 (4) ◽  
pp. 815-824 ◽  
Author(s):  
Kay L.H. Wu ◽  
Yung-Mei Chao ◽  
Shiow-Jen Tsay ◽  
Chen Hsiu Chen ◽  
Samuel H.H. Chan ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Metabolic Syndrome ◽  
Nitric Oxide Synthase ◽  
Rostral Ventrolateral Medulla ◽  
Ventrolateral Medulla ◽  
Oxide Synthase

Cardiovascular effects of opioid antagonist naloxone in rostral ventrolateral medulla of rabbits

1990 ◽  
Vol 258 (2) ◽  
pp. R325-R331 ◽  
Author(s):  
D. A. Morilak ◽  
G. Drolet ◽  
J. Chalmers
Keyword(s):  
Pressor Response ◽  
Cardiovascular Effects ◽  
Rostral Ventrolateral Medulla ◽  
Endogenous Opioids ◽  
Opioid Antagonist ◽  
Ventrolateral Medulla ◽  
Inhibitory Influence ◽  
Beneficial Effects ◽  
Arterial Blood ◽  
Depressor Effect

We have examined the influence of endogenous opioids on the basal and reflex control of arterial blood pressure in the pressor region of the rostral ventrolateral medulla (RVLM) of chloralose-anesthetized rabbits. We tested basal effects both in intact animals and after hypotensive hemorrhage. Bilateral administration of the opiod antagonist naloxone (20 nmol, 100 nl) directly into the RVLM induced a gradual and prolonged increase in mean arterial pressure (MAP) (+17 +/- 2 mmHg). This was preceded by a brief and mild depressor effect (-9 +/- 3 mmHg), which was attributable to a transient reduction in excitability immediately after naloxone injection. When naloxone was administered into the RVLM after hemorrhage (20 ml/kg), it improved recovery of MAP relative to saline controls, again producing a gradual, prolonged pressor response (+29 +/- 5 mmHg). The effect of naloxone on a baroreflex in intact animals was only transient, with a brief, nonsignificant attenuation of the reflex depressor response to aortic nerve stimulation. We conclude that endogenous opioids exert a tonic inhibitory influence on RVLM pressor neurons and that this input remains active after hemorrhage. The RVLM may thus be one site for the beneficial effects of naloxone in preventing circulatory decompensation after hemorrhage. In contrast, opioid neurons are not an essential component of baroreflex-mediated sympathoinhibition in the RVLM.

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