scholarly journals Longitudinal Antibody Dynamics Against Structural Proteins of SARS-CoV-2 in Three COVID-19 Patients Shows Concurrent Development of IgA, IgM, and IgG

2021 ◽  
Vol Volume 14 ◽  
pp. 2497-2506
Author(s):  
Mohd Raeed Jamiruddin ◽  
Md Ahsanul Haq ◽  
Kazuhito Tomizawa ◽  
Eiry Kobatake ◽  
Masayasu Mie ◽  
...  
Keyword(s):  
Structural Proteins ◽  
Concurrent Development ◽  
Antibody Dynamics

Exposure of protein VP7 on the surface of bluetongue virus

1990 ◽  
Vol 48 (3) ◽  
pp. 600-601
Author(s):  
A.D. Hyatt
Keyword(s):  
Bluetongue Virus ◽  
Structural Proteins ◽  
Major Constituent ◽  
Outer Coat ◽  
Virus Particles ◽  
Antibody Recognition ◽  
The Core ◽  
The Family ◽  
Electron Microscopical ◽  
Physical Accessibility

Bluetongue virus (BTV) is the type species os the genus orbivirus in the family Reoviridae. The virus has a fibrillar outer coat containing two major structural proteins VP2 and VP5 which surround an icosahedral core. The core contains two major proteins VP3 and VP7 and three minor proteins VP1, VP4 and VP6. Recent evidence has indicated that the core comprises a neucleoprotein center which is surrounded by two protein layers; VP7, a major constituent of capsomeres comprises the outer and VP3 the inner layer of the core . Antibodies to VP7 are currently used in enzyme-linked immunosorbant assays and immuno-electron microscopical (JEM) tests for the detection of BTV. The tests involve the antibody recognition of VP7 on virus particles. In an attempt to understand how complete viruses can interact with antibodies to VP7 various antibody types and methodologies were utilized to determine the physical accessibility of the core to the external environment.

Hepatitis C Virus Structural Proteins and Activation of Toll-Like Receptors

2005 ◽  
Vol 43 (01) ◽  
Author(s):  
M Hoffmann ◽  
P Henneke ◽  
S Weichert ◽  
H Barth ◽  
B Gissler ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Structural Proteins ◽  
Toll Like Receptors

ARCHITECTURE OF PORTS AND ADAPTERS IN ITERATIVE DEVELOPMENT WITH LIMITATIONS ON TIME

2019 ◽  
Author(s):  
Olexandr Grebenuk ◽  
Volodymyr Pavlenko
Keyword(s):  
System Structure ◽  
Time Constraints ◽  
Iterative Development ◽  
Rest Service ◽  
Defining System ◽  
Rules And Principles ◽  
Concurrent Development ◽  
Iterative Software ◽  
The One ◽  
Mail Service

The application of ports and adapters architecture (other names bulbous, layered, hexagonal) in iterative software development is considered in accordance with the requirements that come in chronological order in the practical example. Each iteration is supported by the schema architecture, problems encountered and their solution. The expediency of using the considered architecture in the iterative development of software with time constraints is shown. The system of collecting data on the concentration of carbon dioxide of the environment and air temperature in real time from a distributed network of sensors with a predetermined geolocation for medical institutions was developed. Put sensor information (ID, commissioning date and end date) in the Google Sheets spreadsheet. The data from the sensors should be collected on the server by REST service. The process of PPP in a specific project with significant time constraints is investigated, applying the rules and principles laid down in the architecture of ports and adapters, using the basic metrics to evaluate the complexity of adding new functionality, testing, concurrent development, speed and ease of development; draw conclusions about the conditions when it is appropriate to apply the chosen software design approach, and the ability of such an approach to perceive software requirements changes. The architecture of ports and adapters is useful if the system has many external integrations (mail service, push messages, databases, reporting system, etc.). The one-way communication with adapters guarantees the integrity of the main algorithmic part of the program. A thorough knowledge of the domain allows you to immediately determine the domain layer. Building a system structure that optimally reflects the domain requires the most time, and it will be costly in the future to correct errors made during the process of defining system layers (interfaces and systems). Domain logic testing is fast due to Unit tests, other tests are easy to write due to the small connectivity between layers. This architecture is not a completely new approach, but it takes the best of OOP, SOLID, DDD and determines how to apply these principles in the best way.

An experimental and theoretical approach to understand Fever, DENF & its cure

2020 ◽  
Vol 20 ◽  
Author(s):  
Vijay Kumar Vishvakarma ◽  
Ramesh Chandra ◽  
Prashant Singh
Keyword(s):  
Catalytic Activity ◽  
Dengue Virus ◽  
Theoretical Approach ◽  
Major Part ◽  
Genomic Structure ◽  
Denv Infection ◽  
Structural Proteins ◽  
Experimental Approaches ◽  
Ns3 Protease ◽  
Prime Target

: Fever is a response of human body due to an increase the temperature against the certain stimuli. It may be associated with several reasons and one of the major causes of fever is mosquito bite. Fever due to dengue virus (DENV) infection is being paid most attention out of several other fevers because of a large number of deaths reported worldwide. Dengue virus is transmitted by biting of the mosquitoes, Aedes aegypti and Aedes albopictus. DENV1, DENV2, DENV3 and DENV4 are the four serotypes of dengue virus and these serotypes have 65% similarities in their genomic structure. Genome of DENV is composed of single stranded RNA and it encodes for the polyprotein. Structural and non-structural proteins (nsP) are the two major part of protese. Researchers have paid high attention on the non-structural protease (nsP) of DENV like nsP1, nsP2A, nsP2B, nsP3, nsP4A, nsP4B and nsP5. The NS2B-NS3 protease of DENV is the prime target of the researchers as it is responsible for the catalytic activity. In the present time, Dengvaxia (vaccine) is being recommended to the patients suffering severely due to DENV infection in few countries only. Till date, neither a vaccine nor an effective medicine is available to combat with all four serotypes. This review describes the fever, its causes and studies to cure the infection due to DENV using theoretical and experimental approaches.

Covid 19 – Structural proteins and prospective drug candidates (Preprint)

2020 ◽  
Author(s):  
A.N Anoopkumar ◽  
Sharrel Rebello ◽  
Embalil Mathachan Aneesh
Keyword(s):  
Causative Agent ◽  
Protein Level ◽  
Drug Targets ◽  
Current Paper ◽  
Structural Proteins ◽  
Drug Candidates ◽  
Propagation Properties

UNSTRUCTURED Covid 19 the causative agent of the current devastating pandemic has turned out to be a notorious virus to all men-irrespective of either common to scientific calibre. Attempts to combat this deadly virus are the need of the hour and quite often the best way to defeat an opponent is to keenly study about its structural and propagation properties. The current paper describes briefly Covid 19 at the genomic, structural and protein level to the best of our knowledge. Furthermore, the prospects of possible drug targets that could aid in the control of this virus are also discussed.

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