scholarly journals Research on Correlation Between Psychological Factors, Mast Cells, and PAR-2 Signal Pathway in Irritable Bowel syndrome

2021 ◽  
Vol Volume 14 ◽  
pp. 1427-1436
Author(s):  
Guanqun Chao ◽  
Zhaojun Wang ◽  
Shuo Zhang
Keyword(s):  
Irritable Bowel Syndrome ◽  
Mast Cells ◽  
Psychological Factors ◽  
Signal Pathway ◽  
Irritable Bowel

scholarly journals Mast Cells in Irritable Bowel Syndrome: A Systematic Review

2019 ◽  
Vol 28 (4) ◽  
pp. 463-472 ◽  
Author(s):  
Luisa Krammer ◽  
Anna Sergeevna Sowa ◽  
Axel Lorentz
Keyword(s):  
Irritable Bowel Syndrome ◽  
Mast Cells ◽  
Psychological Factors ◽  
Significant Positive Correlation ◽  
R Package ◽  
Case Control ◽  
Case Control Studies ◽  
Electronic Search ◽  
Associated Symptoms ◽  
Irritable Bowel

Background and Aims: As mast cells (MC) serve as a link between mucosal immune activity and the nervous system, it is likely they also play a role in the pathogenesis of irritable bowel syndrome (IBS). This connection might be an important factor in the development of IBS-related symptoms. Method: This overview comprises 36 case-control studies published from 2000 to 2018 that investigated MC in bowel biopsies of IBS patients and controls. The studies were selected from PubMed, EMBASE, Central, SemanticScholar by an electronic search, performed using RISMed R package. Results: Significantly increased mucosal MC counts/or density in IBS patients compared to controls was observed in 30 studies. Five studies reported no differences and only one of the studies found a decreased amount of MC in an IBS patient. Furthermore, 15 studies made a statement regarding the correlation between the amount of MC and IBS associated symptoms. A significant positive correlation between MC count and IBS-associated symptoms was found in six investigations. A negative correlation was not reported. Conclusion: The results support the idea that MC are involved in IBS pathophysiology as key players in the interplay between psychological factors and the frequency and severity of IBS symptoms.

scholarly journals Multiple psychological factors predict abdominal pain severity in children with irritable bowel syndrome

2018 ◽  
Vol 31 (2) ◽  
pp. e13509 ◽  
Author(s):  
John M. Hollier ◽  
Miranda A. L. van Tilburg ◽  
Yan Liu ◽  
Danita I. Czyzewski ◽  
Mariella M. Self ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Psychological Factors ◽  
Pain Severity ◽  
Irritable Bowel

Bloating in Irritable Bowel Syndrome Is Associated with Symptoms Severity, Psychological Factors, and Comorbidities

2018 ◽  
Vol 64 (5) ◽  
pp. 1288-1295 ◽  
Author(s):  
Keren Hod ◽  
Yehuda Ringel ◽  
Miranda A. L. van Tilburg ◽  
Tamar Ringel-Kulka
Keyword(s):  
Irritable Bowel Syndrome ◽  
Psychological Factors ◽  
Irritable Bowel

scholarly journals Mast Cell Regulation and Irritable Bowel Syndrome: Effects of Food Components with Potential Nutraceutical Use

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4314 ◽  
Author(s):  
José Antonio Uranga ◽  
Vicente Martínez ◽  
Raquel Abalo
Keyword(s):  
Mast Cell ◽  
Irritable Bowel Syndrome ◽  
Mast Cells ◽  
Gastrointestinal Disorder ◽  
Inflammatory Reactions ◽  
Food Components ◽  
Daily Food ◽  
Release Histamine ◽  
Irritable Bowel

Mast cells are key actors in inflammatory reactions. Upon activation, they release histamine, heparin and nerve growth factor, among many other mediators that modulate immune response and neuron sensitization. One important feature of mast cells is that their population is usually increased in animal models and biopsies from patients with irritable bowel syndrome (IBS). Therefore, mast cells and mast cell mediators are regarded as key components in IBS pathophysiology. IBS is a common functional gastrointestinal disorder affecting the quality of life of up to 20% of the population worldwide. It is characterized by abdominal pain and altered bowel habits, with heterogeneous phenotypes ranging from constipation to diarrhea, with a mixed subtype and even an unclassified form. Nutrient intake is one of the triggering factors of IBS. In this respect, certain components of the daily food, such as fatty acids, amino acids or plant-derived substances like flavonoids, have been described to modulate mast cells’ activity. In this review, we will focus on the effect of these molecules, either stimulatory or inhibitory, on mast cell degranulation, looking for a nutraceutical capable of decreasing IBS symptoms.

Mo2018 - Psychological Factors Influence Symptomatology and Quality of Life in Children with Irritable Bowel Syndrome

2018 ◽  
Vol 154 (6) ◽  
pp. S-881 ◽  
Author(s):  
John M. Hollier ◽  
Miranda A. van Tilburg ◽  
Danita I. Czyzewski ◽  
Mariella M. Self ◽  
Yan Liu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Psychological Factors ◽  
Irritable Bowel

scholarly journals Psychological factors in the irritable bowel syndrome.

Gut ◽  
1988 ◽  
Vol 29 (3) ◽  
pp. 411-412
Author(s):  
P M Smith ◽  
J S Harvey
Keyword(s):  
Irritable Bowel Syndrome ◽  
Psychological Factors ◽  
Irritable Bowel

Mast Cell-Nerve Interactions

Physiology ◽  
2000 ◽  
Vol 15 (5) ◽  
pp. 213-218 ◽  
Author(s):  
Omri Bauer ◽  
Ehud Razin
Keyword(s):  
Atopic Dermatitis ◽  
Mast Cell ◽  
Irritable Bowel Syndrome ◽  
Mast Cells ◽  
Interstitial Cystitis ◽  
Recent Literature ◽  
Irritable Bowel

Mutual associations between nerves and mast cells have been observed in normal conditions and in pathological ones such as human irritable bowel syndrome, atopic dermatitis, interstitial cystitis, and more. Here we review the recent literature in this field, putting emphasis on the enteric, skin, and urinary systems, and the pathophysiological implications of this interaction in them.

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