scholarly journals Characterization of the inflammatory response to four commercial bone graft substitutes using a murine biocompatibility model

2012 ◽  
pp. 13 ◽  
Author(s):  
Jeff Flynn ◽  
Markel ◽  
Guthrie ◽  
Bin Wu ◽  
Song ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Bone Graft ◽  
Bone Graft Substitutes

Immunohistochemical characterization of wound healing at two different bone graft substitutes

2012 ◽  
Vol 41 (5) ◽  
pp. 657-666 ◽  
Author(s):  
M. Sager ◽  
D. Ferrari ◽  
M. Wieland ◽  
M. Dard ◽  
J. Becker ◽  
...  
Keyword(s):  
Wound Healing ◽  
Bone Graft ◽  
Bone Graft Substitutes

scholarly journals Morphological and mechanical characterization of chitosan-calcium phosphate composites for potential application as bone-graft substitutes

2015 ◽  
Vol 31 (4) ◽  
pp. 334-342 ◽  
Author(s):  
Guilherme Maia Mulder van de Graaf ◽  
Andre Luis do Valle De Zoppa ◽  
Rodrigo Crispim Moreira ◽  
Sylma Carvalho Maestrelli ◽  
Rodrigo Fernando Costa Marques ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Graft ◽  
Potential Application ◽  
Mechanical Characterization ◽  
Bone Graft Substitutes

scholarly journals Synthetic bone graft versus autograft or allograft for spinal fusion: a systematic review

2016 ◽  
Vol 25 (4) ◽  
pp. 509-516 ◽  
Author(s):  
Zorica Buser ◽  
Darrel S. Brodke ◽  
Jim A. Youssef ◽  
Hans-Joerg Meisel ◽  
Sue Lynn Myhre ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cohort Studies ◽  
Bone Graft ◽  
Spinal Fusion ◽  
Comparative Studies ◽  
Functional Outcomes ◽  
Retrospective Studies ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Bone Graft Substitutes

The purpose of this review was to compare the efficacy and safety of synthetic bone graft substitutes versus autograft or allograft for the treatment of lumbar and cervical spinal degenerative diseases. Multiple major medical reference databases were searched for studies that evaluated spinal fusion using synthetic bone graft substitutes (either alone or with an autograft or allograft) compared with autograft and allograft. Randomized controlled trials (RCT) and cohort studies with more than 10 patients were included. Radiographic fusion, patient-reported outcomes, and functional outcomes were the primary outcomes of interest. The search yielded 214 citations with 27 studies that met the inclusion criteria. For the patients with lumbar spinal degenerative disease, data from 19 comparative studies were included: 3 RCTs, 12 prospective, and 4 retrospective studies. Hydroxyapatite (HA), HA+collagen, β-tricalcium phosphate (β-TCP), calcium sulfate, or polymethylmethacrylate (PMMA) were used. Overall, there were no differences between the treatment groups in terms of fusion, functional outcomes, or complications, except in 1 study that found higher rates of HA graft absorption. For the patients with cervical degenerative conditions, data from 8 comparative studies were included: 4 RCTs and 4 cohort studies (1 prospective and 3 retrospective studies). Synthetic grafts included HA, β-TCP/HA, PMMA, and biocompatible osteoconductive polymer (BOP). The PMMA and BOP grafts led to lower fusion rates, and PMMA, HA, and BOP had greater risks of graft fragmentation, settling, and instrumentation problems compared with iliac crest bone graft. The overall quality of evidence evaluating the potential use and superiority of the synthetic biological materials for lumbar and cervical fusion in this systematic review was low or insufficient, largely due to the high potential for bias and small sample sizes. Thus, definitive conclusions or recommendations regarding the use of these synthetic materials should be made cautiously and within the context of the limitations of the evidence.

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