scholarly journals Association between levels of vitamin D and inflammatory markers in healthy women

2016 ◽  
pp. 51 ◽  
Author(s):  
Fawaz Azizieh ◽  
Khulood Alyahya ◽  
Raj Raghupathy
Keyword(s):  
Vitamin D ◽  
Inflammatory Markers ◽  
Healthy Women

scholarly journals Inflammation and the Association of Vitamin D and Depressive Symptomatology

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1972
Author(s):  
Ezgi Dogan-Sander ◽  
Roland Mergl ◽  
Anja Willenberg ◽  
Ronny Baber ◽  
Kerstin Wirkner ◽  
...  
Keyword(s):  
Vitamin D ◽  
Depressive Symptoms ◽  
Inflammatory Markers ◽  
Depressive Symptomatology ◽  
Community Sample ◽  
Significant Negative Correlation ◽  
Vitamin D Supplementation ◽  
Complex Relationship ◽  
Moderation Effect ◽  
Mediation Analyses

Depression and vitamin D deficiency are major public health problems. The existing literature indicates the complex relationship between depression and vitamin D. The purpose of this study was to examine whether this relationship is moderated or mediated by inflammation. A community sample (n = 7162) from the LIFE-Adult-Study was investigated, for whom depressive symptoms were assessed via the German version of CES-D scale and serum 25-hydroxyvitamin D (25(OH)D) levels and inflammatory markers (IL-6 and CRP levels, WBC count) were quantified. Mediation analyses were performed using Hayes’ PROCESS macro and regression analyses were conducted to test moderation effects. There was a significant negative correlation between CES-D and 25(OH)D, and positive associations between inflammatory markers and CES-D scores. Only WBC partially mediated the association between 25(OH)D levels and depressive symptoms both in a simple mediation model (ab: −0.0042) and a model including covariates (ab: −0.0011). None of the inflammatory markers showed a moderation effect on the association between 25(OH)D levels and depressive symptoms. This present work highlighted the complex relationship between vitamin D, depressive symptoms and inflammation. Future studies are needed to examine the effect of vitamin D supplementation on inflammation and depressive symptomatology for causality assessment.

scholarly journals Endocan and Circulating Progenitor Cells in Women with Systemic Sclerosis: Association with Inflammation and Pulmonary Hypertension

Biomedicines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 533
Author(s):  
Alberto Lo Gullo ◽  
Giuseppe Mandraffino ◽  
Javier Rodríguez-Carrio ◽  
Michele Scuruchi ◽  
Davide Sinicropi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Systemic Sclerosis ◽  
Progenitor Cells ◽  
Inflammatory Markers ◽  
Cell Number ◽  
Pulmonary Artery Hypertension ◽  
Digital Ulcers ◽  
Potential Marker ◽  
Vitamin D Levels ◽  
Cd34 Cells

Background: Systemic sclerosis (SSc) is characterized by early vasculopathy and fibrosis in the skin, lungs, and other tissues. Vascular manifestations of SSc include Raynaud’s phenomenon, digital ulcers, and pulmonary artery hypertension (PAH). PAH is the second most common cause of mortality in SSc. Circulating CD34+ cells associated with cardiovascular health status in several conditions, including chronic immune-inflammatory disease. CD34+ cell numbers have been found inconstantly reduced in SSc. Endocan, a proteoglycan expressed by endothelial cells, was recently suggested as a marker of vascular stress. We tested the relationships among CD34+ cells, endocan, inflammatory markers, vitamin D levels, and clinical parameters in SSc patients with PAH. METHODS: Standard echocardiography was performed. Vitamin D levels, CD34+ cells, inflammatory markers, endocan plasma levels were determined in 36 female SSc patients (24 diffuse/12 limited) and 36 matched controls (HC). RESULTS: We found no difference in CD34+ and vitamin D levels in SSc as compared to controls; ESR, CRP, fibrinogen, endocan, sPAP were higher in SSc with respect to controls. We found a correlation between endocan and: CD34+ cells (r: −0.540, p = 0.002), pulmonary arterial pressure (sPAP) (r: 0.565, p < 0.001), tricuspid annular plane excursion (TAPSE) (r: −0.311, p < 0.01), and E/A ratio (r: −0.487, p < 0.001), but not with ejection fraction (r: −0.057, p = 0.785) in SSc. CD34+ cells correlate with fibrinogen (r: −0.619, p < 0.001), sPAP (r: −0.404, p = 0.011), E/A (r: 0.470, p < 0.005 in SSc. CONCLUSION: CD34+ cell number was significantly correlated with endocan levels and with sPAP in SSc; endocan and CD34+ progenitor cells might be suggested as a potential marker of disease status.

scholarly journals Association between vitamin D, parathyroid hormone and inflammatory markers in urolithiasis patients

2017 ◽  
Vol 6 (4) ◽  
pp. 240-243
Author(s):  
Shakila Venkatesan ◽  
Kalyani Chakkarai ◽  
Subramaniam Arulvijayavani ◽  
Gandhipuram Periyasamy Senthilkumar ◽  
Ramanitharan Manikandan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Inflammatory Markers

scholarly journals Effects of Nutritional Interventions in the Control of Musculoskeletal Pain: An Integrative Review

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3075
Author(s):  
Carolina Rodrigues Mendonça ◽  
Matias Noll ◽  
Maria Clara Rezende Castro ◽  
Erika Aparecida Silveira
Keyword(s):  
Fatty Acids ◽  
Vitamin D ◽  
Musculoskeletal Pain ◽  
Inflammatory Markers ◽  
Integrative Review ◽  
Food Groups ◽  
Omega 3 ◽  
Fruit Peel ◽  
Nutritional Interventions ◽  
Positive Effects

Food consumption has significant positive effects on an individual’s health status, including the reduction of symptoms associated with musculoskeletal pain. However, specific food groups indicated for the treatment of pain are not yet determined. Hence, this review aimed to analyze the effects of nutritional interventions with specific diets, oils and/or fatty acids, and foodstuffs in natura in the reduction of musculoskeletal pain. An integrative review was conducted in the following databases: Embase, PubMed, LILACS, and Google Scholar. Clinical trials written in English, Spanish, and Portuguese and published between 2000 and March 2020 were included in this review. Seventeen studies were included. Among these, a reduction of musculoskeletal pain with different types of nutritional interventions, such as vegan and Mediterranean diets and the consumption of blueberry, strawberry, passion fruit peel extract, argan oil, fish oil (omega-3), olive oil, and undenatured type II collagen and vitamin D gel capsules, was observed in 14 studies. Eight studies evaluated the profiles of several inflammatory markers, and of these, decreased interleukin (IL)-6, IL-1β, and tumor necrosis factor-α levels were observed in two studies. This review suggests that different nutritional interventions with specific diets, oils and/or fatty acids, and foodstuffs in natura reduce musculoskeletal pain, specifically in adults with osteoarthritis. Besides pain improvement, nutritional interventions, including the consumption of strawberry and vitamin D gel capsules, decrease the levels of several inflammatory markers.

scholarly journals Genetic variation in the human vitamin D receptor is associated with muscle strength, fat mass and body weight in Swedish women

2004 ◽  
pp. 323-328 ◽  
Author(s):  
E Grundberg ◽  
H Brandstrom ◽  
EL Ribom ◽  
O Ljunggren ◽  
H Mallmin ◽  
...  
Keyword(s):  
Vitamin D ◽  
Body Weight ◽  
Genetic Variation ◽  
Muscle Strength ◽  
Body Mass ◽  
Vitamin D Receptor ◽  
Fat Mass ◽  
Restriction Site ◽  
Mineral Density ◽  
Healthy Women

OBJECTIVE: Bone mineral density (BMD) is under strong genetic control and a number of candidate genes have been associated with BMD. Both muscle strength and body weight are considered to be important predictors of BMD but far less is known about the genes affecting muscle strength and fat mass. The purpose of this study was to investigate the poly adenosine (A) repeat and the BsmI SNP in the vitamin D receptor (VDR) in relation to muscle strength and body composition in healthy women. DESIGN: A population-based study of 175 healthy women aged 20-39 years was used. METHODS: The polymorphic regions in the VDR gene (the poly A repeat and the BsmI SNP) were amplified by PCR. Body mass measurements (fat mass, lean mass, body weight and body mass index) and muscle strength (quadriceps, hamstring and grip strength) were evaluated. RESULTS: Individuals with shorter poly A repeat, ss and/or absence of the linked BsmI restriction site (BB) have higher hamstring strength (ss vs LL, P=0.02), body weight (ss vs LL, P=0.049) and fat mass (ss vs LL, P=0.04) compared with women with a longer poly A repeat (LL) and/or the presence of the linked BsmI restriction site (bb). CONCLUSIONS: Genetic variation in the VDR is correlated with muscle strength, fat mass and body weight in premenopausal women. Further functional studies on the poly A microsatellite are needed to elucidate whether this is the functionally relevant locus or if the polymorphism is in linkage disequilibrium with a functional variant in a closely situated gene further downstream of the VDR 3'UTR.

scholarly journals Vitamin D deficiency in postmenopausal, healthy women predicts increased cardiovascular events: a 16-year follow-up study

2012 ◽  
Vol 167 (4) ◽  
pp. 553-560 ◽  
Author(s):  
Louise Lind Schierbeck ◽  
Lars Rejnmark ◽  
Charlotte Landbo Tofteng ◽  
Lis Stilgren ◽  
Pia Eiken ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Cardiovascular Events ◽  
Serum Levels ◽  
Cardiovascular Outcome ◽  
Osteoporosis Prevention ◽  
Healthy Women ◽  
End Point ◽  
Increased Risk

ObjectiveTo investigate the relationship between vitamin D status in healthy women and cardiovascular outcome.Design and methodsBetween 1990 and 1993, 2016 healthy, recently postmenopausal women were enrolled in the Danish Osteoporosis Prevention Study. Serum levels of 25-hydroxyvitamin D (25(OH)D, nmol/l) were measured at baseline. Participants were followed for 16 years. The primary end point was a combination of death, heart failure, myocardial infarction (MI) and stroke. Vitamin D deficiency was defined as serum 25(OH)D<50 nmol/l. The primary end point was adjusted for other risk factors of adverse cardiovascular events (age, smoking, blood pressure, hip–waist ratio, education and family history of MI).ResultsAt baseline, mean age was 50 years and BMI 25. Women with vitamin D deficiency (n=788) had more cardiovascular risk factors than vitamin D-replete women (n=1225). Compared with vitamin D-replete women, women with low 25(OH)D levels had significantly higher BMI and triglycerides, lower HDL and hip–waist ratio and less education. More were smokers among the vitamin D deficient (47 vs 38%). A primary end point was experienced by 118 (15%) with vitamin D deficiency and by 125 (10%) of the vitamin D replete. Hazard ratio (HR) was 1.49 (95% confidence interval: 1.16–1.92;P=0.002) in the vitamin D deficient. Adjusted HR was 1.32 (1.02–1.71;P=0.03). In total, 135 women died; of these, 65 (8%) were of the vitamin D deficient and 70 (6%) in the vitamin D-replete group; unadjusted HR was 1.44 (1.02–2.01;P=0.04) for vitamin D deficiency.ConclusionHealthy women with vitamin D deficiency have increased risk of adverse cardiovascular outcome.

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