scholarly journals c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma

2015 ◽  
pp. 29 ◽  
Author(s):  
Laura Gramantieri ◽  
Alessandro Granito ◽  
Elena Guidetti
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Molecular Target ◽  
Advanced Hepatocellular Carcinoma ◽  
Met Receptor ◽  
Met Receptor Tyrosine Kinase

scholarly journals lncRNA HOTAIR overexpression promotes hybrid epithelial/mesenchymal phenotype through suppression of c-Met Receptor Tyrosine Kinase Signaling in Hepatocellular Carcinoma Cells

2020 ◽  
Author(s):  
Hande Topel ◽  
Ezgi Bagirsakci ◽  
Dehan Comez ◽  
Gulsun Bagci ◽  
Gulcin Cakan-Akdogan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tyrosine Kinase ◽  
Cell Fate ◽  
Receptor Tyrosine Kinase ◽  
Biological Significance ◽  
Met Receptor ◽  
Mesenchymal Transition ◽  
Met Receptor Tyrosine Kinase ◽  
Lncrna Hotair

Abstract Background: Epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) are both reversible processes, and regulation of phenotypical transition is very important for progression of several cancers including hepatocellular carcinoma (HCC). Recently, it is defined that cancer cells can attain a hybrid epithelial/mesenchymal (hybrid E/M) phenotype. Cells with hybrid E/M phenotype comprise mixed epithelial and mesenchymal properties, they can be more resistant to therapeutics and also more capable of initiating metastatic lesions. However, the mechanisms regulating hybrid E/M in HCC are not well described yet. In this study, we investigated the role of the potential crosstalk between lncRNA HOTAIR and c-Met receptor tyrosine kinase, which are two essential regulators of EMT and MET, in acquiring of hybrid E/M phenotype in HCC.Methods: Expression of c-Met and HOTAIR were defined in HCC cell lines and patient tissues through HCC progression. lncRNA HOTAIR was overexpressed in SNU-449 cells and its effects on c-Met signaling were analyzed. c-Met was overexpressed in SNU-398 cells and its effect on HOTAIR expression was analyzed. Biological significance of HOTAIR/c-Met interplay was defined in means of adhesion, proliferation, motility behavior, invasion, spheroid formation and metastatic ability. Effect of ectopic HOTAIR expression on phenotype was defined with investigation of molecular epithelial and mesenchymal traits.Results: In vitro and in vivo experiments verified the pivotal role of lncRNA HOTAIR in acquisition of hybrid E/M phenotype through modulating c-Met and its membrane co-localizing partner Caveolin-1 expression, activation and membrane organization to cope with the rate limiting steps of metastasis such as survival in adhesion independent microenvironment, escaping from anoikis and resisting to fluidic shear stress (FSS) in HCC.Conclusions: Our work provides the first evidence suggesting a role for lncRNA HOTAIR in the modulation of c-Met to promote hybrid E/M phenotype. The balance between lncRNA HOTAIR and c-Met might be critical for cell fate decision and metastatic potential of HCC cells.

scholarly journals Acid sphingomyelinase is required for cell surface presentation of Met receptor tyrosine kinase in cancer cells

2016 ◽  
Vol 129 (22) ◽  
pp. 4238-4251 ◽  
Author(s):  
Linyu Zhu ◽  
Xiahui Xiong ◽  
Yongsoon Kim ◽  
Naomi Okada ◽  
Fei Lu ◽  
...  
Keyword(s):  
Cell Surface ◽  
Tyrosine Kinase ◽  
Cancer Cells ◽  
Receptor Tyrosine Kinase ◽  
Acid Sphingomyelinase ◽  
Met Receptor ◽  
Met Receptor Tyrosine Kinase

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

Nature ◽  
1996 ◽  
Vol 384 (6605) ◽  
pp. 173-176 ◽  
Author(s):  
K. Michael Weidner ◽  
Silvana Di Cesare ◽  
Martin Sachs ◽  
Volker Brinkmann ◽  
Jürgen Behrens ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Epithelial Morphogenesis ◽  
Met Receptor ◽  
Met Receptor Tyrosine Kinase

scholarly journals Disruption of MET Receptor Tyrosine Kinase, an Autism Risk Factor, Impairs Developmental Synaptic Plasticity in the Hippocampus

2018 ◽  
Vol 79 (1) ◽  
pp. 36-50 ◽  
Author(s):  
Xiaokuang Ma ◽  
Ke Chen ◽  
Zhongming Lu ◽  
Mariel Piechowicz ◽  
Qiang Liu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Synaptic Plasticity ◽  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Met Receptor ◽  
Met Receptor Tyrosine Kinase
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