scholarly journals Preclinical Evaluation of the Antihypertensive Effect of an Aqueous Extract of Anogeissus leiocarpa (DC) Guill et Perr. Bark of Trunk in L-NAME-Induced Hypertensive Rat

2021 ◽  
Vol Volume 13 ◽  
pp. 739-754
Author(s):  
Lazare Belemnaba ◽  
Mathieu Nitiéma ◽  
Sylvain Ilboudo ◽  
Gueswindé Geoffroy Ouédraogo ◽  
Noufou Ouédraogo ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Antihypertensive Effect ◽  
Preclinical Evaluation ◽  
Hypertensive Rat

Ruta montana evokes antihypertensive activity through increase of prosta-glandins release in L-NAME-induced hypertensive rats

2020 ◽  
Vol 20 ◽  
Author(s):  
El-Ouady Fadwa ◽  
Mohamed Eddouks
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Aqueous Extract ◽  
Antihypertensive Effect ◽  
Antihypertensive Activity ◽  
Computer Assisted ◽  
Hypertensive Rats ◽  
Vasorelaxant Effect ◽  
Vasorelaxant Activity ◽  
Ruta Montana

Aims: The aim of the study was to investigate experimentally the antihypertensive effect of Ruta Montana. Background: Ruta montana L. is traditionally used in Moroccan herbal medicine to treat hypertension. This study aimed to evaluate experimentally the hypotensive and vasoactive properties of this plant. Objective: The objective of the study was to evaluate the effect of the aqueous extract of Ruta Montana on blood pressure parameters in LNAME-induced hypertensive rats and to determine the vasorelaxant activity of this aqueous extract. Methods: The antihypertensive effect of the aqueous extract obtained from Ruta montana aerial parts (RMAPAE) (200 mg/kg) was evaluated in normal and anesthetized hypertensive rats. Blood pressure parameters (systolic blood pressure (SBP), mean blood pressure (MBP) and diastolic blood pressure (DBP)) and heart rate were measured using a tail-cuff and a computer-assisted monitoring device. The acute and chronic effect of RMAPAE was recorded during 6 hours for the acute experiment and during 7 days for the sub-chronic test. In the other set, the vasorelaxant effect of RMAPAE on the contractile response was undertaken in isolated thoracic aorta. Results: The results indicated that RMAPAE extract significantly decreased SBP, MBP, DBP and heart rate in L-NAMEinduced hypertensive rats. Furthermore, RMAPAE was demonstrated to induce a dose dependent relaxation in the aorta precontracted with Epinephrine or KCl. More interestingly, this vasorelaxant activity of RMAPAE seems to be probably mediated through the prostaglandins pathway. Conclusion: The present study illustrates the beneficial action of Ruta montana on hypertension and supports then its use as an antihypertensive agent.

Antihypertensive Effect of Bauhinia forficata Aqueous Extract in Rats

2013 ◽  
Vol 8 (3) ◽  
pp. 82-89 ◽  
Author(s):  
Paulo Jose Castro do Anjos ◽  
Paulo Roberto Pereira ◽  
Italo Jose Alves Moreira ◽  
Mairim Russo Serafini ◽  
Adriano Antunes Souz Araujo ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Antihypertensive Effect ◽  
Bauhinia Forficata

scholarly journals Preclinical evaluation of diuretic activity of aqueous extract of Solanum xanthocarpum leaves in experimental animals.

2013 ◽  
Vol 3 (4) ◽  
pp. 1023-1026 ◽  
Author(s):  
M.T. Deshmukh . ◽  
R.V. Shete . ◽  
V.T. Deshmukh . ◽  
S.R. Borate . ◽  
S.V. Deshmukh .
Keyword(s):  
Aqueous Extract ◽  
Diuretic Activity ◽  
Experimental Animals ◽  
Preclinical Evaluation ◽  
Solanum Xanthocarpum

scholarly journals ANTIHYPERTENSION STUDY OF ANREDERA CORDIFOLIA (TEN). V. STEENIS EXTRACT AND ITS FRACTIONS IN RATS THROUGH DEXAMETHASONE INDUCTION AND NITRIC OXIDE RELEASE.

2018 ◽  
Vol 11 (1) ◽  
pp. 278
Author(s):  
Afrillia Nuryanti Garmana ◽  
Elin Yulinah Sukandar ◽  
Irda Fidrianny
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Antihypertensive Effect ◽  
Ethanol Extract ◽  
Ethyl Acetate Fraction ◽  
Pressure System ◽  
Rat Serum ◽  
Nitric Oxide Release ◽  
Water Fraction ◽  
Hypertensive Rat

 Objective: The aims of this study were to prove the antihypertensive effect of Anredera cordifolia (Madeira vine) in dexamethasone-induced hypertensive rat and to determine the release of nitric oxide (NO).Methods: The rat’s blood pressure was measured by CODA® tail-cuff blood pressure system. A hypertensive rat model was developed on day 7 after administration of dexamethasone injection 0.5 mg/kg body weight (bw). NO levels were measured by spectrophotometry at a wavelength of 546 nm after reacting the serum sample with Griess reagent.Results: Ethanol extract of Madeira vine (EEMV), ethyl acetate fraction (EF), and water fraction (WF) could reduce systolic blood pressure at day 14 with a diastolic blood pressure (DBP) reduction of 26.8, 34.1, and 40.5 mmHg, respectively. DBP began to decrease from day 8 in the EEMV group with a DBP reduction of 24.1 mmHg. In the HF, EF, and WF groups, decreasing in DBP occurred on day 14 which were 22.0, 24.5, and 35.4 mmHg, respectively. NO level in rat serum was increased significantly at 90 min after administration of EEMV 100 mg/kg bw and WF 40.73 mg/kg bw. Increasing in NO levels due to EF with a dose of 1.66 mg/kg bw was not significantly different to control group.Conclusion: Ethanol extract of A. cordifolia had the antihypertensive effect in dexamethasone-induced hypertensive rats, so does its WF and EF. The mechanism of ethanol extract of Madeira vine leaves and its WF most likely due to vasodilation effect through NO-pathway, whereas EF could have other mechanism(s) of action. 

Preclinical evaluation of hematoprotective and nephroprotective activities of Bellis perennis L aqueous extract on CCl4-induced renal injury in mice

2018 ◽  
Vol 27 (6) ◽  
pp. 1557-1566 ◽  
Author(s):  
Mohammad Mahdi Zangeneh ◽  
Akram Zangeneh ◽  
Reza Tahvilian ◽  
Rohallah Moradi ◽  
Payam Razeghi Tehrani
Keyword(s):  
Aqueous Extract ◽  
Renal Injury ◽  
Preclinical Evaluation

Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariffa

Fitoterapia ◽  
2007 ◽  
Vol 78 (4) ◽  
pp. 292-297 ◽  
Author(s):  
F.B.O. Mojiminiyi ◽  
M. Dikko ◽  
B.Y. Muhammad ◽  
P.D. Ojobor ◽  
O.P. Ajagbonna ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Antihypertensive Effect ◽  
Hibiscus Sabdariffa
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