scholarly journals Effect of Cytokine Gene Polymorphisms on Eltrombopag Reactivity in Japanese Patients with Immune Thrombocytopenia

2021 ◽  
Vol Volume 12 ◽  
pp. 421-429
Author(s):  
Shosaku Nomura ◽  
Misao Abe ◽  
Manabu Yamaoka ◽  
Tomoki Ito
Keyword(s):  
Gene Polymorphisms ◽  
Immune Thrombocytopenia ◽  
Japanese Patients ◽  
Cytokine Gene ◽  
Cytokine Gene Polymorphisms

scholarly journals FRI0550 CAN CYTOKINE GENE POLYMORPHISMS BE USEFUL FOR THE THERAPEUTIC CHOICE IN JAPANESE PATIENTS WITH RHEUMATOID ARTHRITIS?

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 876.2-877
Author(s):  
S. Tsujimoto ◽  
M. Shigesaka ◽  
A. Tanaka ◽  
Y. Ozaki ◽  
T. Ito ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Autoimmune Disease ◽  
Gene Polymorphisms ◽  
Therapeutic Response ◽  
Bone Erosion ◽  
Japanese Patients ◽  
Cartilage Degradation ◽  
Cytokine Gene ◽  
Biological Dmards ◽  
Cytokine Gene Polymorphisms

Background:Rheumatoid arthritis (RA) is a common autoimmune disease. It is characterized by systemic synovitis with bone erosion and joint cartilage degradation(1). Production of autoantibody is important for autoimmune disease. Cytokines play crucial roles in its pathogenesis(2). SNP distribution varies between races. Few studies have examined SNP targeted at Japanese patients. The analysis of cytokine gene polymorphisms is important factor of pathophysiology and treatment.Objectives:This analysis was aimed to investigate the association between cytokine gene polymorphisms and autoantibody and therapeutic response in Japanese RA patients.Methods:This study subjects consisted of 100 RA patients and 50 healthy controls. We extracted data on patient sex, age, disease duration, rheumatoid factor (RF), anti cyclic citrullinated peptide (anti-CCP) antibody and therapeutic response including methotrexate (MTX) and biological DMARDs. Genomic DNA was isolated from peripheral blood, these were genotyped for TNFα, TGFβ1, IL-6, IL-10 and IFNγ polymorphisms. We analyzed these data using a chi-square test.Results:IL-10 (-819 C/T and -592 C/A) revealed that there were significant decrease in the frequency of IL-10 (-819) CC genotype and (-592) CC genotype as compared to controls in RA patients. Genotyping of IL-10 showed that there was significant decrease ACC/ACC genotype (Table 1).IFNγ (+874 A/T) revealed that there was significant decrease in the frequency of TT genotype as compared to controls (Table 1).No significant differences in TNFα, TGFβ1and IL-6 genotypes and alleles frequency were observed between RA patients and control.TGFβ1(+869 A/T) in patients with anti-CCP antibody positive revealed that there was significant decrease in the frequency of TT genotype as compared to patients with anti-CCP antibody negative (Table 2).No significant association between RF and any cytokine gene polymorphism.Analyzing cytokine gene polymorphisms could be useful for treatment with MTX and biological DMARDs.Table 1.Table 2.Conclusion:IL-10 (-819 C/T, -592 C/A) and IFNγ (+874 A/T) polymorphism might be related to RA in Japanese population. In addition, TGFβ1(+869 A/T) polymorphism might be associated with the production of anti-CCP antibody. These results suggest that the analyzing cytokine gene polymorphisms may offer promise as useful factors in the choice of treatment for Japanese RA patients.References:[1] Scott DL, Wolfe F, Huizinga TW. Rheumatoid arthritis. Lancet. 2010; 376: 1094–108.[2] McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol. 2007 Jun;7(6):429-42.Disclosure of Interests:None declared

Cytokine Gene Polymorphisms in Cancer and Inflammatory Disorders

2018 ◽  
Vol 14 (2) ◽  
pp. 81-93
Author(s):  
Hanim Kamis Norhalifah ◽  
Nor Fazila Che Mat ◽  
Hisham Atan Edinur
Keyword(s):  
Gene Polymorphisms ◽  
Cytokine Gene ◽  
Inflammatory Disorders ◽  
Cytokine Gene Polymorphisms

Proinflammatory cytokine gene polymorphisms and susceptibility to Paget’s disease of bone: An association study

Cytokine ◽  
2011 ◽  
Vol 56 (3) ◽  
pp. 560-563 ◽  
Author(s):  
Salvatore Gallone ◽  
Marco Di Stefano ◽  
Pierpaola Fenoglio ◽  
Elisa Rubino ◽  
Antonio Criasia ◽  
...  
Keyword(s):  
Association Study ◽  
Proinflammatory Cytokine ◽  
Gene Polymorphisms ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone ◽  
Cytokine Gene ◽  
Cytokine Gene Polymorphisms

Cytokine gene polymorphisms moderate responses to respiratory syncytial virus in adults

2003 ◽  
Vol 64 (1) ◽  
pp. 93-98 ◽  
Author(s):  
Deborah A Gentile ◽  
William J Doyle ◽  
Adriana Zeevi ◽  
Otavio Piltcher ◽  
David P Skoner
Keyword(s):  
Respiratory Syncytial Virus ◽  
Gene Polymorphisms ◽  
Cytokine Gene ◽  
Cytokine Gene Polymorphisms ◽  
Syncytial Virus

scholarly journals Cytokine gene polymorphisms in acquired bone marrow failure

2007 ◽  
Vol 82 (8) ◽  
pp. 721-724 ◽  
Author(s):  
Vinod Gidvani ◽  
Shakti Ramkissoon ◽  
Elaine M. Sloand ◽  
Neal S. Young
Keyword(s):  
Bone Marrow ◽  
Gene Polymorphisms ◽  
Bone Marrow Failure ◽  
Cytokine Gene ◽  
Cytokine Gene Polymorphisms

Proinflammatory Cytokine Gene Polymorphisms in Irritable Bowel Syndrome

2009 ◽  
Vol 30 (1) ◽  
pp. 74-79 ◽  
Author(s):  
Elham Barkhordari ◽  
Nima Rezaei ◽  
Bita Ansaripour ◽  
Pegah Larki ◽  
Maryam Alighardashi ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Proinflammatory Cytokine ◽  
Gene Polymorphisms ◽  
Cytokine Gene ◽  
Cytokine Gene Polymorphisms ◽  
Irritable Bowel
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