scholarly journals Pharmacokinetics-based clinical management of acquired von Willebrand syndrome: a case report

2018 ◽  
Vol Volume 9 ◽  
pp. 9-13 ◽  
Author(s):  
Candice M Baldeo ◽  
Candido E Rivera ◽  
Han W Tun ◽  
Prakash Vishnu
Keyword(s):  
Case Report ◽  
Clinical Management ◽  
Acquired Von Willebrand Syndrome ◽  
Von Willebrand

scholarly journals Heyde Syndrome: An Unusual Cause of Gastrointestinal Bleeding

2021 ◽  
Vol 9 ◽  
pp. 232470962199727
Author(s):  
Dushyant Singh Dahiya ◽  
Asim Kichloo ◽  
El-Amir Zain ◽  
Jagmeet Singh ◽  
Farah Wani ◽  
...  
Keyword(s):  
Case Report ◽  
Aortic Stenosis ◽  
Severe Aortic Stenosis ◽  
Multisystem Disorder ◽  
Acquired Von Willebrand Syndrome ◽  
Transcatheter Aortic Valve ◽  
Replacement Procedure ◽  
Patient Reported ◽  
History Of ◽  
Von Willebrand

Heyde syndrome is a multisystem disorder characterized by the classical triad of aortic stenosis, gastrointestinal (GI) angiodysplasias, and acquired von Willebrand syndrome. GI angiodysplasias, common in older patients, are tortuous, thin-walled blood vessels seen in the mucosa or submucosa of the GI tract and are highly prone to rupture resulting in GI bleeds. In this case report, we describe an elderly female with a past medical history of end-stage renal disease and chronic anemia who presented to the emergency department (ED) with complaints of dark-tarry stools and associated abdominal cramping. Patient reported a history of dark-tarry stools and multiple blood transfusions in the past, secondary to severe anemia. An inpatient echocardiogram was performed, revealing severe aortic stenosis. Additionally, gastroenterology was consulted for esophagogastroduodenoscopy and colonoscopy, which were negative for active bleeding. About a year ago, the patient underwent capsule endoscopy at an outlying facility, which was positive for angiodysplasia. Therefore, due to high clinical suspicion, presence of aortic stenosis, and GI angiodysplasia, a platelet function assay was ordered. It was found to be abnormal, pointing to the presence of acquired von Willebrand syndrome. Hence, a diagnosis of Heyde syndrome was established. The patient gradually improved and was discharged with a follow-up appointment with the cardiologist for a possible transcatheter aortic valve replacement procedure. The patient underwent the procedure without complications, after which she did not report episodes of GI bleeding. In this case report, we discuss the presentation, pathophysiology, diagnostic approach, and management of patients with Heyde syndrome.

scholarly journals Acquired von Willebrand syndrome and lymphoproliferative disorders: A case report

2020 ◽  
Vol 8 (5) ◽  
pp. 900-904
Author(s):  
Christophe Nicol ◽  
Leela Raj ◽  
Gaëlle Guillerm ◽  
Francis Couturaud ◽  
Jean‐Richard Eveillard ◽  
...  
Keyword(s):  
Case Report ◽  
Lymphoproliferative Disorders ◽  
Acquired Von Willebrand Syndrome ◽  
Von Willebrand
Sign in / Sign up

Export Citation Format

Share Document