scholarly journals Integrative Analysis Reveals a miRNA-mRNA Regulatory Network and Potential Causative Agents in the Asthmatic Airway Epithelium

2021 ◽  
Vol Volume 14 ◽  
pp. 1307-1321
Author(s):  
Jintao Zhang ◽  
Zihan Wang ◽  
Dong Zhang ◽  
Yun Pan ◽  
Xiaofei Liu ◽  
...  
Keyword(s):  
Airway Epithelium ◽  
Regulatory Network ◽  
Integrative Analysis ◽  
Asthmatic Airway ◽  
Causative Agents

scholarly journals Retraction Note: Integrative analysis of the circRNA–miRNA regulatory network in atrial fibrillation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Zhong‑bao Ruan ◽  
Fei Wang ◽  
Qiu‑ping Yu ◽  
Ge‑cai Chen ◽  
Li Zhu
Keyword(s):  
Atrial Fibrillation ◽  
Regulatory Network ◽  
Integrative Analysis

scholarly journals Glutathione S-transferase M1 modulates allergen-induced NF-κB activation in asthmatic airway epithelium

Allergy ◽  
2014 ◽  
Vol 69 (12) ◽  
pp. 1666-1672 ◽  
Author(s):  
V. V. Polosukhin ◽  
I. V. Polosukhin ◽  
A. Hoskins ◽  
W. Han ◽  
R. Abdolrasulnia ◽  
...  
Keyword(s):  
Airway Epithelium ◽  
Glutathione S Transferase ◽  
Asthmatic Airway

scholarly journals Unique MicroRNA and mRNA Interactions in EGFR-Mutated Lung Adenocarcinoma

2018 ◽  
Vol 7 (11) ◽  
pp. 419 ◽  
Author(s):  
Sophia Subat ◽  
Kentaro Inamura ◽  
Hironori Ninomiya ◽  
Hiroko Nagano ◽  
Sakae Okumura ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Mrna Expression ◽  
Regulatory Network ◽  
Egfr Mutation ◽  
Expression Profiles ◽  
Integrative Analysis ◽  
Future Research ◽  
Mutation Status ◽  
Egfr Mutated ◽  
Insight Into

The EGFR gene was one of the first molecules to be selected for targeted gene therapy. EGFR-mutated lung adenocarcinoma, which is responsive to EGFR inhibitors, is characterized by a distinct oncogenic pathway in which unique microRNA (miRNA)–mRNA interactions have been observed. However, little information is available about the miRNA–mRNA regulatory network involved. Both miRNA and mRNA expression profiles were investigated using microarrays in 155 surgically resected specimens of lung adenocarcinoma with a known EGFR mutation status (52 mutated and 103 wild-type cases). An integrative analysis of the data was performed to identify the unique miRNA–mRNA regulatory network in EGFR-mutated lung adenocarcinoma. Expression profiling of miRNAs and mRNAs yielded characteristic miRNA/mRNA signatures (19 miRNAs/431 mRNAs) in EGFR-mutated lung adenocarcinoma. Five of the 19 miRNAs were previously listed as EGFR-mutation-specific miRNAs (i.e., miR-532-3p, miR-500a-3p, miR-224-5p, miR-502-3p, and miR-532-5p). An integrative analysis of miRNA and mRNA expression revealed a refined list of putative miRNA–mRNA interactions, of which 63 were potentially involved in EGFR-mutated tumors. Network structural analysis provided a comprehensive view of the complex miRNA–mRNA interactions in EGFR-mutated lung adenocarcinoma, including DUSP4 and MUC4 axes. Overall, this observational study provides insight into the unique miRNA–mRNA regulatory network present in EGFR-mutated tumors. Our findings, if validated, would inform future research examining the interplay of miRNAs and mRNAs in EGFR-mutated lung adenocarcinoma.

LSC - 2019 - RNA degradation is a deficient antiviral mechanism in the asthmatic airway epithelium

2019 ◽  
Author(s):  
Taowen Wong ◽  
Jennifer Rynne ◽  
Peter H Howarth ◽  
Michael R Edwards ◽  
Rocio Teresa Martinez-Nunez
Keyword(s):  
Airway Epithelium ◽  
Rna Degradation ◽  
Asthmatic Airway ◽  
Antiviral Mechanism

Dysregulated Expression Of IL-13 Receptors In The Asthmatic Airway Epithelium

2012 ◽  
Author(s):  
Shun-Yu Jasemine Yang ◽  
Angela D.R. Saunders ◽  
Sima Allahverdian ◽  
Samuel J. Wadsworth ◽  
Gurpreet K. Singhera ◽  
...  
Keyword(s):  
Airway Epithelium ◽  
Asthmatic Airway

scholarly journals Unjamming and cell shape in the asthmatic airway epithelium

2016 ◽  
Vol 30 (S1) ◽  
Author(s):  
Jeffrey Fredberg ◽  
Jennifer Mitchel ◽  
Jae Hun Kim ◽  
Jin‐Ah Park
Keyword(s):  
Airway Epithelium ◽  
Cell Shape ◽  
Asthmatic Airway

Synchronizing Mitosis Reduces Intrinsic Inflammation In Asthmatic Airway Epithelium

2011 ◽  
Author(s):  
Angela S. Benton ◽  
Alan M. Watson ◽  
Jesse Damsker ◽  
Erica Reeves ◽  
Mary C. Rose ◽  
...  
Keyword(s):  
Airway Epithelium ◽  
Asthmatic Airway
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