scholarly journals The Value of Fractional Exhaled Nitric Oxide and Impulse Oscillometric and Spirometric Parameters for Predicting Bronchial Hyperresponsiveness in Adults with Chronic Cough

2021 ◽  
Vol Volume 14 ◽  
pp. 1065-1073
Author(s):  
Lichang Chen ◽  
Lingling Wu ◽  
Dongzhu Lu ◽  
Mei Zi ◽  
Huapeng Yu
Keyword(s):  
Nitric Oxide ◽  
Chronic Cough ◽  
Bronchial Hyperresponsiveness ◽  
Exhaled Nitric Oxide ◽  
Fractional Exhaled Nitric Oxide

scholarly journals Values of fractional exhaled nitric oxide for cough-variant asthma in children with chronic cough

2018 ◽  
Vol 10 (12) ◽  
pp. 6616-6623 ◽  
Author(s):  
Jing Zhou ◽  
Xianhong Zhao ◽  
Xu Zhang ◽  
Xingmei Yu ◽  
Yuqing Wang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Cough ◽  
Exhaled Nitric Oxide ◽  
Fractional Exhaled Nitric Oxide ◽  
Cough Variant Asthma ◽  
Asthma In Children

scholarly journals Diagnostic utility of fractional exhaled nitric oxide in prolonged and chronic cough according to atopic status

2017 ◽  
Vol 66 (2) ◽  
pp. 344-350 ◽  
Author(s):  
Takamitsu Asano ◽  
Masaya Takemura ◽  
Kensuke Fukumitsu ◽  
Norihisa Takeda ◽  
Hiroya Ichikawa ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Cough ◽  
Exhaled Nitric Oxide ◽  
Diagnostic Utility ◽  
Fractional Exhaled Nitric Oxide ◽  
Atopic Status

Concordance between bronchial hyperresponsiveness, fractional exhaled nitric oxide, and asthma control in children

2016 ◽  
Vol 51 (10) ◽  
pp. 1004-1009 ◽  
Author(s):  
Biju Thomas ◽  
Oh Moh Chay ◽  
John C. Allen ◽  
Andrea Shu Xian Chiang ◽  
Arun Pugalenthi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Asthma Control ◽  
Bronchial Hyperresponsiveness ◽  
Exhaled Nitric Oxide ◽  
Fractional Exhaled Nitric Oxide

scholarly journals Trigger of Bronchial Hyperresponsiveness Development may not always need Eosinophilic Airway Inflammation in Very Early Stage of Asthma

2016 ◽  
Vol 7 (1) ◽  
pp. ar.2016.7.0145 ◽  
Author(s):  
Yasushi Obase ◽  
Terufumi Shimoda ◽  
Reiko Kishikawa ◽  
Shigeru Kohno ◽  
Tomoaki Iwanaga
Keyword(s):  
Nitric Oxide ◽  
Airway Inflammation ◽  
Vital Capacity ◽  
Bronchial Hyperresponsiveness ◽  
Exhaled Nitric Oxide ◽  
Flow Volume ◽  
Impulse Oscillometry ◽  
Eosinophilic Inflammation ◽  
Fractional Exhaled Nitric Oxide ◽  
Sputum Eosinophils

Background Cough variant asthma (CVA), a suggested precursor of standard bronchial asthma (SBA), is characterized by positive bronchial hyperresponsiveness (BHR) and a chronic cough response to bronchodilator that persists for >8 weeks. Objective Airway inflammation, BHR, and airway obstructive damage were analyzed to assess whether CVA represents early or mild-stage SBA. Methods Patients with newly diagnosed CVA (n = 72) and SBA (n = 84) naive to oral or inhaled corticosteroids and without exacerbated asthma were subjected to spirometry, impulse oscillometry, BHR tests, sputum induction, and fractional exhaled nitric oxide measurements. Results In the patients with CVA, spirometry demonstrated higher forced expiratory volume in 1 second (FEV1) to forced vital capacity ratio, FEV1 percent predicted, flow volume at 50% of vital capacity % predicted, and flow volume at 25% of vital capacity % predicted values, and impulse oscillometry demonstrated lower R5–Z20, AX, and Fres, and higher X5 values. In addition, the fractional exhaled nitric oxide and sputum eosinophil numbers were lower and the PC20 was higher than in patients with moderate SBA. However, these factors were similar in the patients with CVA and in the patients with intermittent mild SBA. A significantly smaller proportion of the patients with CVA had increased sputum eosinophils than the patients with intermittent mild SBA (p < 0.0001). However, interestingly, among the patients with CVA, no significant differences in the PC20 values were found between the patients with and those without increased sputum eosinophils. Conclusions All measures of central and peripheral airway obstruction, eosinophilic inflammation, and airway hyperresponsiveness in patients with CVA were milder than in patients with moderate SBA but were similar to those of patients with intermittent mild SBA. In CVA, the BHR was not affected by airway eosinophilic inflammation, which indicated that the very early development of BHR may not always need airway eosinophilic inflammation.

Predictive Value of Fractional Exhaled Nitric Oxide of Airway Eosinophilic Infalmmation in Chronic Cough and Classic Asthma

CHEST Journal ◽  
2016 ◽  
Vol 149 (4) ◽  
pp. A21
Author(s):  
Fang Yi ◽  
Wei Luo ◽  
Ruchong Chen ◽  
Siqi Jiang ◽  
Xu Zhang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Predictive Value ◽  
Chronic Cough ◽  
Exhaled Nitric Oxide ◽  
Fractional Exhaled Nitric Oxide
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