scholarly journals Characteristics of Asthma-related Nocturnal Cough: A Potential New Digital Biomarker

2020 ◽  
Vol Volume 13 ◽  
pp. 649-657
Author(s):  
Frank Rassouli ◽  
Peter Tinschert ◽  
Filipe Barata ◽  
Claudia Steurer-Stey ◽  
Elgar Fleisch ◽  
...  
Keyword(s):  
Nocturnal Cough

A new method for objectively evaluating childhood nocturnal cough

2015 ◽  
Vol 50 (5) ◽  
pp. 460-468 ◽  
Author(s):  
Kota Hirai ◽  
Hideyuki Tabata ◽  
Mariko Hirayama ◽  
Tohru Kobayashi ◽  
Yasumasa Oh ◽  
...  
Keyword(s):  
New Method ◽  
Nocturnal Cough

An objective evaluation of nocturnal cough count and cough pattern in children with psychogenic cough

2017 ◽  
Vol 55 (6) ◽  
pp. 334-337 ◽  
Author(s):  
Eri Imai ◽  
Kota Hirai ◽  
Yoshiko Mikami ◽  
Mariko Nukaga ◽  
Mayumi Enseki ◽  
...  
Keyword(s):  
Objective Evaluation ◽  
Nocturnal Cough

scholarly journals Automatic Recognition, Segmentation, and Sex Assignment of Nocturnal Asthmatic Coughs and Cough Epochs in Smartphone Audio Recordings: Observational Field Study (Preprint)

2020 ◽  
Author(s):  
Filipe Barata ◽  
Peter Tinschert ◽  
Frank Rassouli ◽  
Claudia Steurer-Stey ◽  
Elgar Fleisch ◽  
...  
Keyword(s):  
Early Recognition ◽  
Gaussian Mixture ◽  
Automatic Recognition ◽  
Classification Task ◽  
Data Set ◽  
Chronic Respiratory Diseases ◽  
Audio Recordings ◽  
Audio Data ◽  
Contact Free ◽  
Nocturnal Cough

BACKGROUND Asthma is one of the most prevalent chronic respiratory diseases. Despite increased investment in treatment, little progress has been made in the early recognition and treatment of asthma exacerbations over the last decade. Nocturnal cough monitoring may provide an opportunity to identify patients at risk for imminent exacerbations. Recently developed approaches enable smartphone-based cough monitoring. These approaches, however, have not undergone longitudinal overnight testing nor have they been specifically evaluated in the context of asthma. Also, the problem of distinguishing partner coughs from patient coughs when two or more people are sleeping in the same room using contact-free audio recordings remains unsolved. OBJECTIVE The objective of this study was to evaluate the automatic recognition and segmentation of nocturnal asthmatic coughs and cough epochs in smartphone-based audio recordings that were collected in the field. We also aimed to distinguish partner coughs from patient coughs in contact-free audio recordings by classifying coughs based on sex. METHODS We used a convolutional neural network model that we had developed in previous work for automated cough recognition. We further used techniques (such as ensemble learning, minibatch balancing, and thresholding) to address the imbalance in the data set. We evaluated the classifier in a classification task and a segmentation task. The cough-recognition classifier served as the basis for the cough-segmentation classifier from continuous audio recordings. We compared automated cough and cough-epoch counts to human-annotated cough and cough-epoch counts. We employed Gaussian mixture models to build a classifier for cough and cough-epoch signals based on sex. RESULTS We recorded audio data from 94 adults with asthma (overall: mean 43 years; SD 16 years; female: 54/94, 57%; male 40/94, 43%). Audio data were recorded by each participant in their everyday environment using a smartphone placed next to their bed; recordings were made over a period of 28 nights. Out of 704,697 sounds, we identified 30,304 sounds as coughs. A total of 26,166 coughs occurred without a 2-second pause between coughs, yielding 8238 cough epochs. The ensemble classifier performed well with a Matthews correlation coefficient of 92% in a pure classification task and achieved comparable cough counts to that of human annotators in the segmentation of coughing. The count difference between automated and human-annotated coughs was a mean –0.1 (95% CI –12.11, 11.91) coughs. The count difference between automated and human-annotated cough epochs was a mean 0.24 (95% CI –3.67, 4.15) cough epochs. The Gaussian mixture model cough epoch–based sex classification performed best yielding an accuracy of 83%. CONCLUSIONS Our study showed longitudinal nocturnal cough and cough-epoch recognition from nightly recorded smartphone-based audio from adults with asthma. The model distinguishes partner cough from patient cough in contact-free recordings by identifying cough and cough-epoch signals that correspond to the sex of the patient. This research represents a step towards enabling passive and scalable cough monitoring for adults with asthma.

scholarly journals 0960 Perception of Sleep Importance in Children With Cystic Fibrosis

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A364-A365
Author(s):  
K Reiling ◽  
A Patel
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Sleep Problems ◽  
Pulmonary Function Tests ◽  
Poor Sleep ◽  
Airway Clearance ◽  
The Mean ◽  
Nocturnal Cough ◽  
Perception Of Sleep

Abstract Introduction Children with cystic fibrosis (CF) are known to have poor sleep efficiency and increased nighttime awakenings secondary to factors such as nocturnal cough and time spent on therapies for airway clearance. Studies have shown that children with poor lung function have a higher Pediatric Daytime Sleepiness Score (PDSS). An increase in sleep disturbance has been associated with poorer perceived health in children with CF. There have been limited studies to date that report the perception of sleep importance in CF patients. We aim to characterize the perception of sleep importance in children with CF as measured through a self-reported questionnaire and identify barriers to sleep. Methods After IRB approval, subjects with CF aged 3-17 years were prospectively recruited from routine pulmonology clinic visits (n=28, 17 male). A questionnaire was provided consisting of 35 questions regarding sleep practices, perception of sleep importance, and PDSS. Recent pulmonary function tests (PFTs) were also collected. Results The mean PDSS was 11.3, with a range of 4 to 24. The questionnaire responses were as follows: 82% of participants reported sleep as “very important” overall, 92% reported sleep being “very important” for health, and 75% reported sleep being “very important” for lung function. In addition, 39% reported airway clearance as part of their nighttime routine and 89% reported utilizing electronic screens 2 hours prior to bed. The most frequent barriers to sleep identified were technology and bedtime resistance (14% each), and homework, excitability, and vest/airway treatments (11% each). 86% of participants had at least one symptom of disordered sleep. Conclusion Screening for sleep problems in the CF population may be beneficial and may contribute to improved quality of life. Further recruitment is ongoing. Support  

scholarly journals Prevalence of nocturnal cough in asthma and its potential as a marker for asthma control (MAC) in combination with sleep quality: protocol of a smartphone-based, multicentre, longitudinal observational study with two stages

BMJ Open ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. e026323 ◽  
Author(s):  
Peter Tinschert ◽  
Frank Rassouli ◽  
Filipe Barata ◽  
Claudia Steurer-Stey ◽  
Elgar Fleisch ◽  
...  
Keyword(s):  
Observational Study ◽  
Sleep Quality ◽  
Asthma Control ◽  
Asthma Control Test ◽  
Eligibility Criteria ◽  
Longitudinal Observational Study ◽  
Study Results ◽  
Patient Reported ◽  
Two Stages ◽  
Nocturnal Cough

IntroductionNocturnal cough is a burdensome asthma symptom. However, knowledge about the prevalence of nocturnal cough in asthma is limited. Furthermore, prior research has shown that nocturnal cough and impaired sleep quality are associated with asthma control, but the association between these two symptoms remains unclear. This study further investigates the potential of these symptoms as markers for asthma control and the accuracy of automated, smartphone-based passive monitoring for nocturnal cough detection and sleep quality assessment.Methods and analysisThe study is a multicentre, longitudinal observational study with two stages. Sensor and questionnaire data of 94 individuals with asthma will be recorded for 28 nights by means of a smartphone. On the first and the last study day, a participant’s asthma will be clinically assessed, including spirometry and fractionated exhaled nitric oxide levels. Asthma control will be assessed by the Asthma Control Test and sleep quality by means of the Pittsburgh Sleep Quality Index. In addition, nocturnal coughs from smartphone microphone recordings will be labelled and counted by human annotators. Relatively unrestrictive eligibility criteria for study participation are set to support external validity of study results. Analysis of the first stage is concerned with the prevalence and trends of nocturnal cough and the accuracies of smartphone-based automated detection of nocturnal cough and sleep quality. In the second stage, patient-reported asthma control will be predicted in a mixed effects regression model with nocturnal cough frequencies and sleep quality of past nights as the main predictors.Ethics and disseminationThe study was reviewed and approved by the ethics commission responsible for research involving humans in eastern Switzerland (BASEC ID: 2017–01872). All study data will be anonymised on study termination. Results will be published in medical and technical peer-reviewed journals.Trial registration numberNCT03635710; Pre-results.

Nocturnal cough in children with stable cystic fibrosis

2009 ◽  
Vol 44 (9) ◽  
pp. 859-865 ◽  
Author(s):  
Lianne van der Giessen ◽  
Martine Loeve ◽  
Johan de Jongste ◽  
Wim Hop ◽  
Harm Tiddens
Keyword(s):  
Cystic Fibrosis ◽  
Nocturnal Cough

scholarly journals Persistent nocturnal cough in childhood: a population based study.

1995 ◽  
Vol 73 (5) ◽  
pp. 403-407 ◽  
Author(s):  
T K Ninan ◽  
L Macdonald ◽  
G Russell
Keyword(s):  
Population Based ◽  
Population Based Study ◽  
Nocturnal Cough

Pulmonary Acoustics and Esophageal pH Monitoring in Infantile Nocturnal Cough

2004 ◽  
Vol 17 (4) ◽  
pp. 262-271 ◽  
Author(s):  
Lea Bentur ◽  
Raphael Beck ◽  
Drora Berkowitz ◽  
Jamal Hasanin ◽  
Irit Berger ◽  
...  
Keyword(s):  
Ph Monitoring ◽  
Esophageal Ph Monitoring ◽  
Esophageal Ph ◽  
Nocturnal Cough

scholarly journals Vapor Rub, Petrolatum, and No Treatment for Children With Nocturnal Cough and Cold Symptoms

PEDIATRICS ◽  
2010 ◽  
Vol 126 (6) ◽  
pp. 1092-1099 ◽  
Author(s):  
I. M. Paul ◽  
J. S. Beiler ◽  
T. S. King ◽  
E. R. Clapp ◽  
J. Vallati ◽  
...  
Keyword(s):  
Nocturnal Cough

scholarly journals Nocturnal cough in asthma.

1987 ◽  
Vol 62 (10) ◽  
pp. 1001-1004 ◽  
Author(s):  
A H Thomson ◽  
C Pratt ◽  
H Simpson
Keyword(s):  
Nocturnal Cough
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