scholarly journals The association between Lambert–Eaton myasthenic syndrome and small cell lung carcinoma

2013 ◽  
pp. 31
Author(s):  
Denis Talbot ◽  
Briggs ◽  
Gozzard
Keyword(s):  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Myasthenic Syndrome

Difficulty Climbing the Stairs

2021 ◽  
pp. 149-151
Author(s):  
Anastasia Zekeridou ◽  
Vanda A. Lennon
Keyword(s):  
Computed Tomography ◽  
Intravenous Immunoglobulin ◽  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Concurrent Chemotherapy ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
History Of ◽  
Myasthenic Syndrome

A 72-year-old woman with a history of rheumatoid arthritis and chronic obstructive pulmonary sought care for a 3-month history of progressive difficulty walking on uneven terrain and climbing stairs. In the 2 preceding weeks, she also noted difficulty standing up from a seated position. She reported no sensory symptoms but recently noticed dry mouth and new-onset constipation with decreased appetite. Electromyography showed diffusely low-amplitude compound muscle action potential responses to single-nerve stimuli at rest, with normal sensory nerve action potentials. Studies of the ulnar and femoral motor nerves demonstrated a decrement to low-frequency repetitive stimulation (12%) and substantial postexercise facilitation (200%) and decrement repair. The serum was positive for cyclic citrullinated peptide antibody, rheumatoid factor, and P/Q-type voltage-gated calcium channel antibody. Computed tomography of the chest showed subcarinal and right hilar lymphadenopathy without evidence of a primary lesion, with avidity on 18F-fludeoxyglucose–positron emission tomography/computed tomography. Transbronchial fine-needle aspiration biopsy of the lymph node revealed small cell lung carcinoma. The patient was diagnosed with Lambert-Eaton myasthenic syndrome and small cell lung carcinoma. Concurrent chemotherapy and radiation were administered for the small cell lung carcinoma, with some improvement of the patient’s weakness. Symptomatic treatment for Lambert-Eaton myasthenic syndrome was initiated. Therapy with 3,4-diaminopyridine improved the patient’s weakness, but her daily activities were limited by persistent, moderate, lower extremity weakness. The weakness objectively improved with intravenous immunoglobulin therapy. Two years later, the patient was maintained on 3,4-diaminopyridine and monthly intravenous immunoglobulin, with minimal persistent weakness and no evidence of cancer recurrence. Lambert-Eaton myasthenic syndrome was first described at Mayo Clinic in 1956 as a “myasthenic syndrome associated with malignant tumors” that had characteristic electromyographic findings, later shown to be presynaptic by microelectrophysiologic testing.

Anesthesia for an Unsuspected Lambert-Eaton Myasthenic Syndrome with Autoantibodies and Occult Small Cell Lung Carcinoma

1992 ◽  
Vol 76 (1) ◽  
pp. 142-144 ◽  
Author(s):  
STEPHEN SMALL ◽  
HASSAN H. ALI ◽  
VANDA A. LENNON ◽  
ROBERT H. BROWN ◽  
DANIEL B. CARR ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Myasthenic Syndrome

scholarly journals A Case of Small Cell Lung Carcinoma with SIADH and Lambert-Eaton Myasthenic Syndrome.

Haigan ◽  
1993 ◽  
Vol 33 (3) ◽  
pp. 429-435
Author(s):  
Takashi Shibusa ◽  
Yuji Inoue ◽  
Mitsuo Asakawa ◽  
Chiaki Hamamatsu ◽  
Masakatsu Ando
Keyword(s):  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Myasthenic Syndrome

Long‐term prognosis of Japanese Lambert–Eaton myasthenic syndrome patients with or without small‐cell lung carcinoma

2020 ◽  
Vol 11 (2) ◽  
pp. 131-134
Author(s):  
Yuta Kojima ◽  
Akiyuki Uzawa ◽  
Kazumoto Shibuya ◽  
Manato Yasuda ◽  
Yukiko Ozawa ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Myasthenic Syndrome ◽  
Long Term Prognosis

HLA-B8 in Patients with the Lambert-Eaton Myasthenic Syndrome Reduces Likelihood of Associated Small Cell Lung Carcinoma

2003 ◽  
Vol 998 (1) ◽  
pp. 200-201 ◽  
Author(s):  
PAUL W. WIRTZ ◽  
NICK WILLCOX ◽  
BART O. ROEP ◽  
BETHAN LANG ◽  
AXEL R. WINTZEN ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Myasthenic Syndrome
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