scholarly journals Immunotherapy in Merkel cell carcinoma: role of Avelumab

2018 ◽  
Vol Volume 7 ◽  
pp. 15-19 ◽  
Author(s):  
Amruth Palla ◽  
Donald Doll
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Merkel Cell

The essential role of radiation therapy in securing locoregional control of merkel cell carcinoma

1990 ◽  
Vol 19 (3) ◽  
pp. 583-591 ◽  
Author(s):  
William H. Morrison ◽  
Lester J. Peters ◽  
Elvio G. Silva ◽  
Charles D. Wendt ◽  
K.Kian Ang ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Essential Role ◽  
Locoregional Control ◽  
Merkel Cell

The clinical utility of neuron-specific enolase serum levels as a biomarker for Merkel cell carcinoma.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 9570-9570 ◽  
Author(s):  
Linde M. van Veenendaal ◽  
Eduardo Bertolli ◽  
Catharina M. Korse ◽  
W. Martin. C. Klop ◽  
Margot Et Tesselaar ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Cox Regression ◽  
Neuron Specific Enolase ◽  
Distant Metastases ◽  
Serum Levels ◽  
Optimal Level ◽  
Rank Test ◽  
Merkel Cell

9570 Background: To date no adequate biomarker for Merkel Cell carcinoma (MCC) has been identified. The introduction of immunotherapy (IT) for metastatic MCC increases the need for a biomarker. Serum Neuron-specific enolase (NSE) has already been tested and is commonly used as a biomarker for several small cell malignancies. However, the role of NSE in MCC is still unclear. Aim: To investigate the role of NSE as a biomarker in MCC. Methods: A prospective cohort of MCC patients treated from 2016 to July 2018 was analyzed. Kaplan Meier curves with log rank test, Cox regression and mixed models were used to analyze NSE. A separate evaluation was performed for patients treated with IT. Results: A total of 78 patients (42 males, median age 71 years, stage I&II, III and IV MCC in 37(47%), 39(50%) and 2(3%) patients at time of diagnosis with 474 NSE levels (median 15 ; IQR 12,6-22 ng/ml were included. Baseline NSE (n=36) had no influence on survival or progression. During follow-up (FU) NSE levels correlated with tumorload (p=0,01) with increase of 15 ng/ml per class (no tumorload, localized MCC, nodal and distant metastases, respectively). NSE level during FU was able to detect progression (AUC 0,89). Several cut off values were evaluated. A NSE of 18,2 ng/ml was considered the most optimal level for clinical use (sensitivity 91%, specificity 78%, PPV 48%, NPV 98% to detect progression). During IT (n=16; 195 NSE values) all complete responders (n=7) had a normalized NSE (<18,2 ng/ml), all partial responders (n=3) had a decreasing NSE. In non-responders (n=6) all NSE levels remained elevated, one patient responded after switching to different IT with normalizing NSE values. Conclusions: NSE seems to be a valuable biomarker in MCC. NSE correlates with tumorload; is able to rule out progression and distinguishes responders from non-responders during IT.

Role of Radiotherapy in the Management of Merkel Cell Carcinoma of the Skin

2006 ◽  
Vol 4 (7) ◽  
pp. 713-718 ◽  
Author(s):  
Roy H. Decker ◽  
Lynn D. Wilson
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Clinical Judgment ◽  
Low Risk ◽  
Combined Modality Treatment ◽  
Adjuvant Radiation ◽  
Merkel Cell ◽  
Primary Tumor Site ◽  
Regional Disease

The role of radiotherapy in treating local and regional disease in patients with clinically localized Merkel cell carcinoma remains controversial. Given the lack of randomized evidence and patient and treatment heterogeneity in published retrospective series, sound clinical judgment is required to assess individual patient risk factors. Although many single-institution series have shown that adjuvant radiation to the primary tumor site decreases the risk for local and regional failure, evidence is emerging that there is a cohort of patients at relatively low risk for local recurrence after wide local excision alone. Node dissection, radiotherapy, and combined modality treatment may all play a role in managing occult or clinically evident nodal disease, depending on the anatomic location of draining lymphatics and the extent of microscopic or macroscopic disease. For select patients, primary radiotherapy is a reasonable option with a low risk for local or regional recurrence.

scholarly journals Merkel cell carcinoma-derived exosome-shuttle miR-375 induces fibroblast polarization by inhibition of RBPJ and p53

Oncogene ◽  
2020 ◽  
Author(s):  
Kaiji Fan ◽  
Ivelina Spassova ◽  
Jan Gravemeyer ◽  
Cathrin Ritter ◽  
Kai Horny ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Cancer Associated Fibroblasts ◽  
Merkel Cell ◽  
Intercellular Signaling ◽  
Related Gene ◽  
Malignant Phenotype ◽  
Signaling Function

AbstractMerkel cell carcinoma (MCC) is a highly invasive and metastatic skin cancer. While high expression of miR-375 is a characteristic of MCC, it seems not to contribute to the malignant phenotype of MCC cells. miR-375 enrichment in MCC-derived extracellular vesicles suggests its intercellular signaling function. Here, we demonstrate that horizontally transferred miR-375 causes fibroblast polarization toward cancer-associated fibroblasts (CAFs). The polarization is evidenced by phenotypic changes and induction of α-SMA, CXCL2, and IL-1β. Fibroblast polarization is inhibited by specific antagomirs and mimicked by experimental miR-375 expression. Mechanistically, miR-375 downregulates RBPJ and p53, two key players regulating fibroblast polarization. In clinical MCC samples, in situ hybridization located miR-375 in CAFs, which correlated with high α-SMA protein and low RBPJ and TP53 expression; single-cell RNAseq revealed a disparate fibroblast polarization negatively correlating with p53 pathway-related gene expression. Thus, the functional role of miR-375 in MCC is to generate a pro-tumorigenic microenvironment by inducing fibroblast polarization.

scholarly journals Exploring the Prognostic Role of Ki67 Proliferative Index in Merkel Cell Carcinoma of the Skin: Clinico-Pathologic Analysis of 84 Cases and Review of the Literature

2020 ◽  
Vol 31 (4) ◽  
pp. 392-400 ◽  
Author(s):  
Stefano La Rosa ◽  
Matteo Bonzini ◽  
Amedeo Sciarra ◽  
Sofia Asioli ◽  
Roberta Maragliano ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Prognostic Value ◽  
Univariate Analysis ◽  
Youden Index ◽  
Merkel Cell ◽  
Prognostic Role ◽  
Proliferative Index

AbstractThe exact prediction of outcome of patients with Merkel cell carcinoma (MCC) of the skin is difficult to determine, although several attempts have been made to identify clinico-pathologic prognostic factors. The Ki67 proliferative index is a well-known marker routinely used to define the prognosis of patients with neuroendocrine neoplasms. However, its prognostic value has been poorly investigated in MCC, and available published results are often contradictory mainly because restricted to small series in the absence of standardized methods for Ki67 evaluation. For this reason, we explored the potential prognostic role of Ki67 proliferative index in a large series of MCCs using the WHO standardized method of counting positive cells in at least 500 tumor cells in hot spot areas on camera-captured printed images. In addition, since MCC may be considered as the cutaneous counterpart of digestive neuroendocrine carcinomas (NECs), we decided to stratify MCCs using the available and efficient Ki67 threshold of 55%, which was found prognostic in digestive NECs. This choice was also supported by the Youden index analysis. In addition, we analyzed the prognostic value of other clinico-pathologic parameters using both univariate and multivariate analysis. Ki67 index appeared significantly associated with prognosis at univariate analysis together with stage IV, lack of MCPyV, and p63 expression, but not at the multivariate analysis, where survival resulted independently influenced by p63 expression and tumor stage, only.

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