scholarly journals Treatment with sodium hyaluronate eye drops in a patient who had early-onset bleb leakage after trabeculectomy with mitomycin C

2015 ◽  
pp. 301 ◽  
Author(s):  
Hideto Sagara ◽  
Tetsuju Sekiryu ◽  
Hiroki Noji ◽  
Keiko Yago ◽  
Masashi Ogasawara ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Early Onset ◽  
Sodium Hyaluronate ◽  
Eye Drops

scholarly journals Sodium hyaluronate eye drops prevent late-onset bleb leakage after trabeculectomy with mitomycin C

Eye ◽  
2006 ◽  
Vol 22 (4) ◽  
pp. 507-514 ◽  
Author(s):  
H Sagara ◽  
T Iida ◽  
K Suzuki ◽  
T Fujiwara ◽  
H Koizumi ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Late Onset ◽  
Sodium Hyaluronate ◽  
Eye Drops

Comparison of the Effectiveness of Mitomycin-C and Viscoat on Delayed Adjustable Strabismus Surgery in Rabbits

2005 ◽  
Vol 15 (5) ◽  
pp. 530-535 ◽  
Author(s):  
Y. Cengiz ◽  
Ö. Altintas ◽  
G. Manav Ay ◽  
Y. Çaglar
Keyword(s):  
Mitomycin C ◽  
Chondroitin Sulphate ◽  
Adhesion Formation ◽  
Sodium Hyaluronate ◽  
Rectus Muscle ◽  
Strabismus Surgery ◽  
Early Postoperative Period ◽  
Group V ◽  
Significant Difference ◽  
Group 6

Purpose To determine a way to prevent the formation of adhesions and delay the time of suture adjustment in the course of adjustable strabismus surgery, an animal study was performed to assess and compare the effects of mitomycin C (Mit-C) and viscoelastic material Viscoat (sodium hyaluronate 3% and chondroitin sulphate 4%, Alcon, Fort Worth, TX). Methods Right eyes of 47 rabbits were divided into three groups. After recession of the superior rectus muscle (SRM), Mit-C was administered beneath and over the SRM in Group M (16 eyes), Viscoat was administered beneath and over SRM in Group V (16 eyes), and ringer lactate was administered in Group C (15 eyes). SRM then recessed 5 mm with adjustable strabismus surgery technique. Animals in each group were subdivided into 1 and 2, where 1 = adjustment 1 week postoperatively and 2 = adjustment 3 weeks postoperatively. Delayed adjustment was performed in M1 group (6 eyes), V1 group (6 eyes), and C1 group (7 eyes) after 1 week; in M2 group (6 eyes), V2 group (6 eyes), and C2 group (6 eyes) after 3 weeks. Histopathologic examinations were performed for the remaining 10 eyes without suture adjustment at the end of first and third weeks after adjustable strabismus surgery. The possible length and the necessary force to adjust and the degree of adhesions were recorded. Results When length and strength of the adjustment, adhesions between muscle and sclera, and adhesions between muscle and conjunctiva were taken into consideration, there was no statistically significant difference among M, V, and C groups at postoperative weeks 1 and 3. The force needed for adjustment in M1 group was statistically lower than M2 group. Conclusions The intraoperative use of Mit-C (0.4 mg/mL) may decrease adhesion formation in the early postoperative period, especially in the first week. The intraoperative use of Viscoat was not effective in reducing postoperative adhesions and delaying adjustment.

scholarly journals Avoiding BAK in postoperative eye drops reduces the need for subconjunctival 5-FU injections post-trabeculectomy

2020 ◽  
Vol 17 (1) ◽  
pp. 128-131
Author(s):  
Keith Ong ◽  
Leonard Ong
Keyword(s):  
Intraocular Pressure ◽  
Mitomycin C ◽  
T Test ◽  
Topical Steroids ◽  
Eye Drops ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Group A ◽  
Group B ◽  
Causes Of Failure

Purpose: Subconjunctival fibrosis is one of the main causes of failure of glaucoma filtration surgery. It can result in absence of a filtration bleb, a small scarred bleb, or a cystic bleb. 5-Fluorouracil (5-FU), mitomycin C (MMC), and topical steroids have been used to suppress subconjunctival fibrosis. Method: A study was done analyzing the number of postoperative subconjunctival 5-FU injections for trabeculectomy on pseudophakic eyes prior to and following the change to a BAK-free regimen. The cohort consisted of 16 consecutive cases undergoing primary trabeculectomy without intraoperative MMC or 5-FU. The trabeculectomy surgery included a groove sclerectomy procedure. Group A were 8 eyes of patients who had the author’s standard Chlorsig, Maxidex, and Prednefrin Forte eye drops tds. Group B were 8 eyes who had Chlorsig-dexamethasone and Optive-dexamethasone tds eye drops postoperatively. Results: Group B (BAK-free) patients required fewer postoperative 5-FU subconjunctival injections (average: 2.9, range: 1-5 injections) compared to Group A (BAK) patients (average: 7.3, range: 4-18 injections). This difference was statistically significant (P = 0.02, unpaired t-test). All patients had functioning blebs and did not require glaucoma medications to maintain target intraocular pressure. The Group B (BAK-free) patients had more diffuse blebs than the Group A (BAK) patients. Conclusion: The results demonstrated that when BAK was eliminated from postoperative eye drops in trabeculectomy, the number of postoperative 5-FU injections was reduced.

scholarly journals Comparison of the effects of Mitomycin-C and sodium hyaluronate/carboxymethylcellulose [NH/CMC] (Seprafilm) on abdominal adhesions

SpringerPlus ◽  
2016 ◽  
Vol 5 (1) ◽  
Author(s):  
Ismail Hakkı Ozerhan ◽  
Murat Urkan ◽  
Ulvi Mehmet Meral ◽  
Aytekin Unlu ◽  
Nail Ersöz ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Sodium Hyaluronate ◽  
Abdominal Adhesions

scholarly journals Preparation and Evaluation of Topically Applied Azithromycin Based on Sodium Hyaluronate in Treatment of Conjunctivitis

Pharmaceutics ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 183
Author(s):  
Chen ◽  
Yin ◽  
Ma ◽  
Tu ◽  
Shen
Keyword(s):  
Acute Toxicity ◽  
Hydroxypropyl Methylcellulose ◽  
Sodium Hyaluronate ◽  
Drug Formulation ◽  
Resonance Spectroscopy ◽  
Eye Drops ◽  
Scanning Calorimetry ◽  
Eye Irritation

Azithromycin (AZI) eye drops containing sodium hyaluronate (SH) were developed to improve the bioavailability of AZI. Interaction between AZI and SH in the AZI-SH formulation was investigated by differential scanning calorimetry, X-ray diffraction, and 1H-nuclear magnetic resonance spectroscopy analyses. Moreover, advantages of using SH as an excipient were investigated by comparing physiological properties and pharmacokinetic behaviors of SH-containing AZI eye drops with that of hydroxypropyl methylcellulose (HPMC)-containing formulation. In addition, safety of the developed AZI-SH eye drops was evaluated by in vitro 3-(4,5-dimethyl-2-Thiazyl)-2, 5-diphenyl-2H-tetrazolium bromide assay (MTT assay) and neutral red uptake assay as well as in vivo eye irritation test and acute toxicity test. The results indicated that AZI formed a complex with SH under a slightly acidic condition. The area under the curve (AUC) of AZI in SH-containing formulation was 1.58-fold higher (P<0.01) than that in HPMC-containing formulation due to the interaction between the amine group of AZI and the carboxyl group of SH, despite of the higher viscosity of HPMC-containing formulation. Safety evaluation showed that AZI-SH eye drops caused no obvious eye irritation and acute toxicity. In conclusion, the developed SH-containing AZI formulation possessing advantages of longer retention time and higher drug availability was a promising drug formulation for topical ocular therapy.

scholarly journals Delayed Onset Scleromalacia and Conjunctival Bleb Formation Following Intraoperative Mitomycin C Application during Conjunctival Melanoma Excision

Vision ◽  
2020 ◽  
Vol 4 (2) ◽  
pp. 24
Author(s):  
Syed Naqib Ahmed ◽  
Syed Mohammed Shahid ◽  
Mayank A. Nanavaty
Keyword(s):  
Mitomycin C ◽  
Eye Drops ◽  
Conjunctival Melanoma ◽  
Freeze Thaw ◽  
Delayed Onset ◽  
Oral Steroids ◽  
Bleb Formation ◽  
Eye Examination ◽  
One Year ◽  
Conjunctival Bleb

Purpose: To present a case of delayed onset scleromalacia and conjunctival bleb formation one year after conjunctival melanoma excision with intraoperative use of mitomycin-C (MMC) and double-freeze-thaw technique. Methods: Case report. Results: A 69-year-old woman had a conjunctival melanoma excised by the ‘no touch technique’ with intraoperative application of 0.02% MMC for 3 min on bare sclera, freeze-thaw cryotherapy and amniotic membrane transplant performed elsewhere. Three months later, she presented to us with a red, sore and painful right eye. Examination revealed severe scleritis. She was treated with lubricants and oral steroids for 6 weeks. She settled well with no recurrence of melanoma. At one year, she developed scleromalacia and conjunctival blebs in the inferonasal quadrant of right eye. She remains under closer observation as she is at high risk of perforation. Conclusion: Caution should be exercised with intraoperative use of MMC on bare sclera during excision and cryotherapy of conjunctival melanoma. As published in the literature, when using MMC, it is recommended to use the lowest dose topically in the form of eye drops in the postoperative period for the shortest time to avoid any sight-threatening complications.

EFFICACY OF SODIUM HYALURONATE EYE DROPS OF DIFFERENT OSMOLARITY IN THE SYMPTOMATIC TREATMENT OF DRY EYE PATIENTS.

Cornea ◽  
2000 ◽  
Vol 19 (Supplement 2) ◽  
pp. S105
Author(s):  
Giovanni Milazzo ◽  
Vincenzo Papa ◽  
Pasquale Aragona ◽  
Simona Russo ◽  
Piero Russo ◽  
...  
Keyword(s):  
Dry Eye ◽  
Sodium Hyaluronate ◽  
Symptomatic Treatment ◽  
Eye Drops
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