scholarly journals Long-term effects of aliskiren on blood pressure and the renin-angiotensin-aldosterone system in hypertensive hemodialysis patients

2012 ◽  
pp. 45 ◽  
Author(s):  
Yoshiyuki Morishita ◽  
Yoshiyuki Morishita ◽  
Ichiro Hirahara ◽  
Shigeaki Muto ◽  
Eiji Kusano ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Hemodialysis Patients ◽  
Long Term Effects ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin

Long-term effects of telmisartan on blood pressure, the renin-angiotensin-aldosterone system, and lipids in hypertensive patients

2010 ◽  
Vol 25 (3) ◽  
pp. 195-202 ◽  
Author(s):  
Akiko Aoki ◽  
Tetsuya Ogawa ◽  
Hiroyuki Sumino ◽  
Hisao Kumakura ◽  
Yoshiaki Takayama ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Long Term Effects ◽  
Renin Angiotensin Aldosterone System ◽  
Hypertensive Patients ◽  
Renin Angiotensin

Long-term effects (>24 months) of multiple lifestyle intervention on major cardiovascular risk factors among high risk subjects: a meta-analysis

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
H Bergum ◽  
I Sandven ◽  
TO Klemsdal
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Systolic Blood Pressure ◽  
Total Cholesterol ◽  
Cardiovascular Risk Factors ◽  
Lifestyle Intervention ◽  
Small Study ◽  
Long Term Effects

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): The Norwegian health department Background The evidence of the long-term effects of multiple lifestyle intervention on cardiovascular risk is uncertain. We aimed to summarize the evidence from randomized clinical trials examining the efficacy of lifestyle intervention on major cardiovascular risk factors in subjects at high cardiovascular risk. Methods  Eligible trials investigated the impact of lifestyle intervention versus usual care with minimum 24 months follow-up, reporting more than one major cardiovascular risk factor. A literature search updated April 15, 2020 identified 12 eligible studies. The results from individual trials were combined using fixed and random effect models, using the standardized mean difference (SMD) to estimate effect sizes. Small-study effect was evaluated, and heterogeneity between studies examined by subgroup and meta-regression analyses considering patient- and study-level variables. Results  Small-study effect was not identified. Lifestyle intervention reduced systolic blood pressure modestly with an estimated SMD of -0.13, 95% confidence interval (CI): -0.21 to -0.04, with moderate heterogeneity (I² = 59%), corresponding to a mean difference of approximately 2 mmHg (MD = -1.86, 95% CI: -3.14 to -0.57, p = 0.0046). This effect disappeared in the subgroup of trials judged at low risk of bias (SMD = 0.02, 95% CI: -0.08 to 0.11). For the outcome total cholesterol SMD was -0.06, 95% CI: -0.13 to 0.00, with no heterogeneity (I² = 0%), indicating no effect of the intervention. Conclusion  Lifestyle intervention resulted in only a modest effect on systolic blood pressure and no effect on total cholesterol after 24 months. Further lifestyle trials should consider the challenge of maintaining larger long-term benefits to ensure impact on cardiovascular outcomes.

scholarly journals B-PO03-043 LONG TERM EFFECTS OF CARDIAC NEUROMODULATION THERAPY ON SYSTOLIC BLOOD PRESSURE IN CONTROL PATIENTS AFTER CROSS OVER TO THERAPY

Heart Rhythm ◽  
2021 ◽  
Vol 18 (8) ◽  
pp. S205-S206
Author(s):  
Zbigniew Kalarus ◽  
Bela Merkely ◽  
Marcin Grabowski ◽  
Petr Neuzil ◽  
Germanas Marinskis ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Long Term Effects
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