scholarly journals Correlation Between Parathyroid Hormone Levels with Urinary Magnesium Excretion in Patients with Non-Dialysis Dependent Chronic Kidney Disease

2020 ◽  
Vol Volume 13 ◽  
pp. 341-348
Author(s):  
Raimunda Sheyla Carneiro Dias ◽  
Dyego José de Araújo Brito ◽  
Elisângela Milhomem dos Santos ◽  
Rayanna Cadilhe de Oliveira Costa ◽  
Andrea Martins Melo Fontenele ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Parathyroid Hormone ◽  
Kidney Disease ◽  
Hormone Levels ◽  
Magnesium Excretion

Relationship between vitamin D status, parathyroid hormone levels and bone mineral density in patients with chronic kidney disease stages 3 and 4

Nephrology ◽  
2007 ◽  
Vol 0 (0) ◽  
pp. 070918212946008-??? ◽  
Author(s):  
ARISTEIDIS STAVROULOPOULOS ◽  
CHRISTINE J PORTER ◽  
SIMON D ROE ◽  
DAVID J HOSKING ◽  
MICHAEL JD CASSIDY
Keyword(s):  
Bone Mineral Density ◽  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Parathyroid Hormone ◽  
Kidney Disease ◽  
Bone Mineral ◽  
Vitamin D Status ◽  
Mineral Density ◽  
Hormone Levels ◽  
Disease Stages

scholarly journals Correlation Between Serum Parathormone Levels With Urinary Magnesium Excretion In Patients With Non-Dialytic Chronic Kidney Disease

2020 ◽  
Author(s):  
Raimunda Sheyla Carneiro Dias ◽  
Dyego José Araújo Brito ◽  
Joyce Santos Lages ◽  
Alcione Miranda Santos ◽  
Elisangela Milhomen Santos ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Parathyroid Hormone ◽  
Kidney Disease ◽  
Serum Calcium ◽  
Mineral Metabolism ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
Magnesium Excretion ◽  
Serum Pth

Abstract Background: Disorders of mineral metabolism occur in most patients with chronic kidney disease (CKD). The aim of this work was to correlate serum parathyroid hormone (PTH) levels with urinary magnesium excretion in patients with non-dialysis CKD.Methods: Cross-sectional study with patients with CKD undergoing non-dialysis treatment in stages 3A, 3B and 4. Concentrations of creatinine, magnesium, calcium, phosphorus, parathyroid hormone (PTH), 25-hydroxyvitamin D [25(OH)D] and alkaline phosphatase (ALP) were determined in blood samples. The assessment of urinary magnesium levels was performed by means of total daily excretion and by the excretion fraction (FEMg). Results: The study evaluated 163 patients with a mean age of 60.7 ± 11.7 years and 51.0% were male. In the highest quartile of PTH (> 89.5pg / ml), the mean levels of FEMg and ALP were higher (p <0.05), as well as the levels of serum calcium and eGFR were lower (p <0.05). In the unadjusted regression analysis, the following variables were related to serum PTH levels: FEMg (odds ratio (OR) = 1.12; 95% confidence intervals (CI): 1.02–1.23), Calcium (OR = 0.45; 95% CI: 0.22-0.90), ALP (OR = 1.02; 95% CI: 1.00-1.03) and eTFG (OR = 0.92; 95% CI: 1.00-1.03). After an adjusted analysis, only one FEMg and ALP will remain correlated with PTH. Conclusion: In patients with non-dialysis CKD, with higher levels of PTH, higher mean columns of ALP and FEMg, and lower levels of serum calcium and eGFR. FEMg and ALP were some variables that remained associated with PTH.

scholarly journals The Correlation between Estimated Glomerular Filtration Rate and Parathyroid Hormone Levels in Predialysis-chronic Kidney Disease Adult Patients at Sanglah General Hospital, Bali, Indonesia

2021 ◽  
Vol 9 (B) ◽  
pp. 470-474
Author(s):  
Sianny Herawati ◽  
Yenny Kandarini ◽  
I Putu Yuda Prabawa
Keyword(s):  
Chronic Kidney Disease ◽  
Glomerular Filtration Rate ◽  
Parathyroid Hormone ◽  
Kidney Disease ◽  
Glomerular Filtration ◽  
General Hospital ◽  
Filtration Rate ◽  
Adult Patients ◽  
Exclusion Criteria ◽  
Hormone Levels

BACKGROUND: Chronic kidney disease (CKD) is a structural or functional kidney disease for more than 3 months. In predialysis CKD patients, the serum parathyroid hormone levels increase progressively since the early stages of the disease to maintain phosphate homeostasis. Glomerular filtration rate (GFR) has been widely accepted to assess renal function. The GFR assessment is used to determine the CKD stadium. AIM: This study aims to analyze the correlation between GFR and parathyroid hormone levels in predialysis CKD patients undergoing treatment at Sanglah General Hospital Denpasar. METHODS: A cross-sectional observational study was conducted among predialysis CKD patients undergoing treatment at Sanglah General Hospital Denpasar who met the inclusion and exclusion criteria. The inclusion criteria were adult patients (≥18 years) who were accepting to participate in the study. Exclusion criteria were patients with predialysis CKD after thyroidectomy and/or parathyroidectomy and liver disease. The parathyroid hormone levels, blood urea nitrogen, creatinine, and GFR were examined and analyzed by SPSS version 17 for Windows. RESULTS: A total of 77 patients with predialysis CKD in this study obtained a median of e-GFR of 21.09 (4.72–75.80) mL/min/1.73 m2. The median level of parathyroid hormone was 82.07 pg/mL (15.83–716.60 pg/mL). Spearman’s correlation analysis results obtained a strong and significant negative correlation between the e-GFR value and parathyroid hormone levels (r = −0.540; p = 0.000). CONCLUSION: The parathyroid hormone levels assessment could be used as a recommendation in evaluating the CKD progressivity among predialysis adult patients at Sanglah General Hospital, Bali, Indonesia, due to the strong significant correlation.

Obesity is associated with increased parathyroid hormone levels independent of glomerular filtration rate in chronic kidney disease

Metabolism ◽  
2010 ◽  
Vol 59 (3) ◽  
pp. 385-389 ◽  
Author(s):  
Georges Saab ◽  
Adam Whaley-Connell ◽  
Samy I. McFarlane ◽  
Suying Li ◽  
Shu-Cheng Chen ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Glomerular Filtration Rate ◽  
Parathyroid Hormone ◽  
Kidney Disease ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Hormone Levels

scholarly journals Association between Allelic Variations of -174G/C Polymorphism of Interleukin-6 Gene and Chronic Kidney Disease-Mineral and Bone Disorder in Iraqi Patients

2020 ◽  
Vol 17 (4) ◽  
pp. 1145
Author(s):  
Mohanad Radeef
Keyword(s):  
Chronic Kidney Disease ◽  
Parathyroid Hormone ◽  
Kidney Disease ◽  
Vitamin D3 ◽  
Interleukin 6 ◽  
Maintenance Hemodialysis ◽  
Control Group ◽  
Significant Elevation ◽  
Mineral And Bone Disorder ◽  
Hormone Levels

This study designed to examine association between-174G/C polymorphism of interleukin-6 gene and phosphate, calcium, vitamin D3, and parathyroid hormone levels in Iraqi patient with chronic kidney disease on maintenance hemodialysis. Seventy chronic renal failure patients (patients group) and 20 healthy subjects (control group) were genotyped for interleukin-6 polymorphism and genotyping was performed by conventional polymerase chain reaction-restriction fragment length polymorphism. No significant differences in phosphate levels were observed in patients and control with different interleukin-6 genotypes. Control had non-significant differences in calcium levels, while patients with GG and CG genotypes displayed significant elevation with time. Conversely, control and patients with GG and CC genotypes had significant elevation in vitamin D3 levels with time. Regarding parathyroid hormone, control had non-significant differences, while patients with GG and CC genotypes displayed significant elevation with time. Patients with GG genotype displayed significant changes in calcium, vitamin D3 and parathyroid hormone levels with time.

scholarly journals Correlation Between Serum Parathormone Levels With Urinary Magnesium Excretion in Patients With Non-Dialytic Chronic Kidney Disease

2020 ◽  
Author(s):  
Raimunda Sheyla Carneiro Dias ◽  
Dyego José Araújo Brito ◽  
Joyce Santos Lages ◽  
Alcione Miranda Santos ◽  
Elisangela Milhomen Santos ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Alkaline Phosphatase ◽  
Parathyroid Hormone ◽  
Kidney Disease ◽  
Mineral Metabolism ◽  
Serum Magnesium ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Daily Excretion ◽  
Magnesium Excretion

Abstract Background: Disorders of mineral metabolism occur in most patients with chronic kidney disease (CKD). The aim of this work was to correlate serum parathyroid hormone (PTH) levels with urinary magnesium excretion in patients with non-dialysis CKD. Methods: Cross-sectional study with patients with CKD undergoing non-dialysis treatment in stages 3A, 3B and 4. Concentrations of creatinine, magnesium, calcium, phosphorus, parathyroid hormone, vitamin D and alkaline phosphatase were determined in blood samples. The assessment of urinary magnesium levels was performed by means of total daily excretion and by the excretion fraction (FEMg). Results: The study evaluated 163 patients with mean age of 60.7 ± 11.7 and 51.0% were male. A positive correlation was observed between PTH and alkaline phosphatase (r = 0.26; p = 0.006) and FEMg (r = 0.17; p = 0.020). Calcium (r = -0.23; p = 0.002), magnesium in 24-hour urine (r = -0.18; p = 0.020) and estimated glomerular filtration rate (r = -0.47; p = 0.001) demonstrated negative correlation with PTH. Conclusion: Elevated levels of PTH correlated positively with FEMg, regardless of the presence of serum magnesium alterations, and FEMg can be used as another indicator for the treatment of hyperparathyroidism.

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