scholarly journals Mesoamerican Nephropathy (MeN): What We Know so Far

2020 ◽  
Vol Volume 13 ◽  
pp. 261-272 ◽  
Author(s):  
Vicente Sanchez Polo ◽  
Ramon Garcia-Trabanino ◽  
Guillermo Rodriguez ◽  
Magdalena Madero
Keyword(s):  
Mesoamerican Nephropathy

scholarly journals Clinical markers to predict progression from acute to chronic kidney disease in Mesoamerican nephropathy

2018 ◽  
Vol 94 (6) ◽  
pp. 1205-1216 ◽  
Author(s):  
Rebecca S.B. Fischer ◽  
Chandan Vangala ◽  
Sreedhar Mandayam ◽  
Denis Chavarria ◽  
Ramón García-Trabanino ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Clinical Markers ◽  
Mesoamerican Nephropathy

scholarly journals Untangling Mesoamerican Nephropathy

2018 ◽  
Vol 72 (4) ◽  
pp. 469-471 ◽  
Author(s):  
Diego Aguilar-Ramirez ◽  
Magdalena Madero
Keyword(s):  
Mesoamerican Nephropathy

scholarly journals Is an Environmental Nephrotoxin the Primary Cause of CKDu (Mesoamerican Nephropathy)? PRO

Kidney360 ◽  
2020 ◽  
Vol 1 (7) ◽  
pp. 591-595 ◽  
Author(s):  
Marc E. De Broe ◽  
Bejamin A. Vervaet
Keyword(s):  
Mesoamerican Nephropathy

scholarly journals Environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican nephropathy

2019 ◽  
Vol 76 (12) ◽  
pp. 920-926 ◽  
Author(s):  
Evangelia-Theano Smpokou ◽  
Marvin González-Quiroz ◽  
Carla Martins ◽  
Paula Alvito ◽  
Jennifer Le Blond ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
At Risk ◽  
Young Adults ◽  
Kidney Function ◽  
Inductively Coupled Plasma ◽  
Limit Of Detection ◽  
Total Arsenic ◽  
Mesoamerican Nephropathy ◽  
2,4 Dichlorophenoxyacetic Acid

ObjectivesThere is an epidemic of Mesoamerican nephropathy (MeN) in Central America, where sugarcane production is prominent. Numerous causes are proposed, but to date limited evidence supports any one hypothesis. A nested case–control study using biosamples from a rural, community-based follow-up study of 350 young adults from Northwest Nicaragua at risk of MeN was conducted with the aim of characterising the associations between urinary concentrations of metals, pesticides and mycotoxins from samples collected in the first 6 months and decline in kidney function over 2 years.MethodsUrine samples collected at baseline (pre-sugarcane harvest) and the first 6 month follow-up (post-sugarcane harvest) visit were tested. Twelve metals and metalloids (aluminium, total arsenic, cadmium, chromium, cobalt, copper, lead, manganese, mercury, selenium, silicon and strontium) were analysed by inductively coupled plasma-mass spectrometry. Twelve pesticides or their metabolites (2,4-dichlorophenoxyacetic acid, 3-phenoxybenzoic acid, 4-fluoro-3-phenoxybenzoic acid, chloro-3,3,3-trifluoro-1-propen-1-yl-2,2-dimethylcyclopropanecarboxylic acid, cis/trans 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid, ethylenethiourea, glyphosate, 4-chloro-2-methylphenoxy acetic acid, 3-hydroxy-pyrimetanil, 5-hydroxytiabendazole, hydroxy-tebuconazole and 3,5,6-trichloro-2-pyridinol) and two mycotoxins (ochratoxin A (OTA) and citrinin (CIT)) were analysed by liquid chromatography coupled-mass spectrometry. Differences in the creatinine-corrected urinary concentrations of the measured exposures between outcome groups (participants with stable vs declining kidney function) were examined.ResultsElevated levels of aluminium and total arsenic as well as metabolites of several pesticides were detected across the population. No differences were identified between the declining and stable groups in the levels of metals or pesticides tested. OTA and CIT were below the limit of detection.ConclusionsThe tested metals, metalloids, pesticides and mycotoxins were not associated with loss of kidney function in participants at-risk of MeN.

scholarly journals Mesoamerican nephropathy: geographical distribution and time trends of chronic kidney disease mortality between 1970 and 2012 in Costa Rica

2015 ◽  
Vol 72 (10) ◽  
pp. 714-721 ◽  
Author(s):  
Catharina Wesseling ◽  
Berna van Wendel de Joode ◽  
Jennifer Crowe ◽  
Ralf Rittner ◽  
Negin A Sanati ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Costa Rica ◽  
Kidney Disease ◽  
Geographical Distribution ◽  
Time Trends ◽  
Disease Mortality ◽  
Mesoamerican Nephropathy
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