scholarly journals Tetracycline-grafted PLGA nanoparticles as bone-targeting drug delivery system

2015 ◽  
pp. 5671 ◽  
Author(s):  
Hong Yuan ◽  
Hua Wang ◽  
Jun Liu ◽  
Shan Tao ◽  
Guihong Chai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Plga Nanoparticles ◽  
Bone Targeting

scholarly journals PLGA nanoparticles loaded with antitumoral drug as a Drug Delivery System

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Diego Juscelino Santos Dias ◽  
Graziella A Joanitti ◽  
Luciano P Silva ◽  
Claure N Lunardi ◽  
Anderson J Gomes
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Plga Nanoparticles

scholarly journals Pharmacokinetic and Biodistribution Studies of a Bone-Targeting Drug Delivery System Based onN-(2-Hydroxypropyl)methacrylamide Copolymers

2006 ◽  
Vol 3 (6) ◽  
pp. 717-725 ◽  
Author(s):  
Dong Wang ◽  
Monika Sima ◽  
R. Lee Mosley ◽  
Jasmine P. Davda ◽  
Nicole Tietze ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Bone Targeting ◽  
Biodistribution Studies ◽  
Hydroxypropyl Methacrylamide

Doxycycline containing hydroxyapatite ceramic microspheres as a bone‐targeting drug delivery system

2020 ◽  
Vol 108 (4) ◽  
pp. 1351-1362 ◽  
Author(s):  
Carlos Soriano‐Souza ◽  
Helder Valiense ◽  
Elena Mavropoulos ◽  
Victor Martinez‐Zelaya ◽  
Andrea Machado Costa ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hydroxyapatite Ceramic ◽  
Bone Targeting

scholarly journals Enhanced antitumor efficacy on colon cancer using EGF functionalized PLGA nanoparticles loaded with 5-Fluorouracil and perfluorocarbon

2019 ◽  
Author(s):  
Pingping Wu ◽  
Qing Zhou ◽  
Huayun Zhu ◽  
Yan Zhuang ◽  
Jun Bao
Keyword(s):  
Drug Delivery ◽  
Colon Cancer ◽  
Tumor Growth ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vitro Release ◽  
Plga Nanoparticles ◽  
Therapeutic Drug ◽  
Histopathological Analysis ◽  
Sw620 Cells

Abstract Recurrence and metastasis are the shortcomings of the clinical treatment of colon cancer. Finding an efficacy strategy for the treatment of colon cancer is important. In recent years, PLGA has been shown to have potential as a broad therapeutic drug delivery system. this study aimed to design a dual-loaded nanoparticles drug delivery system to overcome the limitations of chemotherapeutic drugs in colon cancer therapy. We developed epidermal growth factor (EGF) functionalized poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) co-loaded with 5-fluorouracil (5Fu) and perfluorocarbon (PFC) (EGF-PLGA@5Fu/PFC) for target therapy of colon cancer. EGF-PLGA@5Fu /PFC NPs were estimated to have an average size of 200 nm with a 5Fu-loading efficiency of 7.29%. In vitro release profile exhibited a pH-responsive release. CCK-8, Hoechst33342 staining and flow cytometry assays were performed to investigate the functions of EGF-PLGA@5Fu/PFC NPs in SW620 cells. Targeted EGF-PLGA@5Fu/PFC NPs also exhibited higher cellular uptake than non-targeted NPs in colon cancer cells. EGF-PLGA@5Fu/PFC NPs were found to have the best efficiency on cell viability suppression and apoptosis induction in SW620 cells. In xenograft mice, EGF-PLGA@5Fu/PFC NPs had the best suppressive effects on tumor growth compared with 5Fu, PLGA@5Fu and PLGA@5Fu/PFC NPs. The results of histopathological analysis further indicated that EGF-targeted NPs were the most efficient on tumor growth inhibition. Mechanically, the data demonstrated the improved therapeutic outcomes were owing to the fact that PFC could relieve tumor hypoxia via transporting oxygen to the tumor. We creatively constructed a biocompatible nanodrug delivery system and functionalized nanoparticles may provide new potential for selective delivery of chemotherapy drugs to cancers.

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