scholarly journals Cross talk between poly(ADP-ribose) polymerase 1 methylation and oxidative stress involved in the toxic effect of anatase titanium dioxide nanoparticles

2015 ◽  
pp. 5561 ◽  
Author(s):  
Ai Gao ◽  
Wenlin Bai ◽  
Yujiao Chen
Keyword(s):  
Oxidative Stress ◽  
Titanium Dioxide ◽  
Toxic Effect ◽  
Cross Talk ◽  
Titanium Dioxide Nanoparticles ◽  
And Oxidative Stress

scholarly journals In Vitro Effects of Titanium Dioxide Nanoparticles (TiO2NPs) on Cadmium Chloride (CdCl2) Genotoxicity in Human Sperm Cells

Nanomaterials ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 1118 ◽  
Author(s):  
Marianna Santonastaso ◽  
Filomena Mottola ◽  
Concetta Iovine ◽  
Fulvio Cesaroni ◽  
Nicola Colacurci ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Titanium Dioxide ◽  
Dna Fragmentation ◽  
Titanium Dioxide Nanoparticles ◽  
Human Sperm ◽  
Sperm Cells ◽  
Sperm Dna Fragmentation ◽  
Sperm Dna ◽  
And Oxidative Stress

The environmental release of titanium dioxide nanoparticles (TiO2NPs) associated with their intensive use has been reported to have a genotoxic effect on male fertility. TiO2NP is able to bind and transport environmental pollutants, such as cadmium (Cd), modifying their availability and/or toxicity. The aim of this work is to assess the in vitro effect of TiO2NPs and cadmium interaction in human sperm cells. Semen parameters, apoptotic cells, sperm DNA fragmentation, genomic stability and oxidative stress were investigated after sperm incubation in cadmium alone and in combination with TiO2NPs at different times (15, 30, 45 and 90 min). Our results showed that cadmium reduced sperm DNA integrity, and increased sperm DNA fragmentation and oxidative stress. The genotoxicity induced by TiO2NPs-cadmium co-exposure was lower compared to single cadmium exposure, suggesting an interaction of the substances to modulate their reactivity. The Quantitative Structure-Activity Relationship (QSAR) computational method showed that the interaction between TiO2NPs and cadmium leads to the formation of a sandwich-like structure, with cadmium in the middle, which results in the inhibition of its genotoxicity by TiO2NPs in human sperm cells.

Titanium dioxide nanoparticles induced cytotoxicity, oxidative stress and DNA damage in human amnion epithelial (WISH) cells

2012 ◽  
Vol 26 (2) ◽  
pp. 351-361 ◽  
Author(s):  
Quaiser Saquib ◽  
Abdulaziz A. Al-Khedhairy ◽  
Maqsood A. Siddiqui ◽  
Faisal M. Abou-Tarboush ◽  
Ameer Azam ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Human Amnion

Abstract 1375: Brain Renin Angiotensin Blockade Attenuates Cytokines and Oxidative Stress in the Paraventricular Nucleus of Hypothalamus and Decreases Sympathoexcitation in Heart Failure Rats

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Ying Ma ◽  
Yu-Ming Kang* ◽  
Zhi-Ming Yang ◽  
Joseph Francis*
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Paraventricular Nucleus ◽  
Cross Talk ◽  
Renin Angiotensin System ◽  
Heart Weight ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
The Brain ◽  
And Oxidative Stress

Introduction: Neurohumoral mechanisms play an important role in the pathophysiology of congestive heart failure (HF). Recent studies suggest that the brain renin angiotensin system (RAS) plays an important role in regulating body fluids and sympathetic drive in HF. In addition, it has been shown that there is cross talk between cytokines and RAS in cardiovascular disease. In this study we determined whether blockade of brain RAS attenuate inflammatory cytokines and oxidative stress in HF rats. Methods and Results: Adult male Sprague-Dawley rats were implanted with intracerebroventricular (ICV) cannulae and subjected to coronary artery ligation to induce HF and confirmed by echocardiography. Rats were treated with an angiotensin type 1 receptors (AT1-R) antagonist losartan (LOS, 20 μg/hr, ICV) or vehicle (VEH) for 4 weeks. At the end of the study, left ventricular (LV) function was measured by echocardiography and rats were sacrificed, and brain and plasma samples were collected for measurements of cytokines and superoxide using immunohistochemistry, Western blot and real time RT-PCR. HF rats induced significant increases in Nuclear Factor-kappaB (NF-κB) p50-positive neurons and activated microglia in the paraventricular nucleus (PVN) of hypothalamus, and TNF-α, IL-1β, IL-6 and NF-κB p50 in hypothalamus when compared with sham rats. These animals also had increased staining for dihydroethidium (DHE) and plasma levels of norepinephrine (NE), an indirect indicator of sympathetic activity. In contrast, ICV treatment with LOS attenuated cytokine expression and oxidative stress in the PVN and hypothalamus when compared with VEH treated HF rats. ICV treatment with LOS also reduced plasma NE levels, and proinflammatory cytokine, heart weight to body weight ratio with decreased LV end-diastolic pressure. Conclusions : These findings suggest the cross talk between the cytokines and renin angiotensin system within the brain contribute to sympatho-excitation in HF.

Toxic effect of titanium dioxide nanoparticles on human mesenchymal stem cells

2020 ◽  
Vol 16 (3) ◽  
pp. 321-330
Author(s):  
Peralta-Vega Adriana-Berenice ◽  
Parra-Barrera Alberto ◽  
Ramos-Godínez María del Pilar ◽  
López-Marure Rebeca ◽  
Arellano-Galindo José ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Titanium Dioxide ◽  
Toxic Effect ◽  
Titanium Dioxide Nanoparticles ◽  
Human Mesenchymal Stem Cells

Oxidative stress and apoptosis induced by titanium dioxide nanoparticles in cultured BEAS-2B cells

2008 ◽  
Vol 180 (3) ◽  
pp. 222-229 ◽  
Author(s):  
Eun-Jung Park ◽  
Jongheop Yi ◽  
Kyu-Hyuck Chung ◽  
Doug-Young Ryu ◽  
Jinhee Choi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles

Titanium dioxide nanoparticles promote oxidative stress, autophagy and reduce NLRP3 in primary rat astrocytes

2020 ◽  
Vol 317 ◽  
pp. 108966 ◽  
Author(s):  
José Antonio Pérez-Arizti ◽  
José Luis Ventura-Gallegos ◽  
Roberto Erasmo Galván Juárez ◽  
María del Pilar Ramos-Godinez ◽  
Zaira Colín-Val ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Rat Astrocytes

Circadian clock and oxidative Stress: functional cross-talk in skin homeostasis

2018 ◽  
Vol 120 ◽  
pp. S161
Author(s):  
M. Benedusi ◽  
E. Frigato ◽  
A. Romani ◽  
C. Bertolucci ◽  
G. Valacchi
Keyword(s):  
Oxidative Stress ◽  
Circadian Clock ◽  
Cross Talk ◽  
And Oxidative Stress
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