scholarly journals Polyetherimide-grafted Fe3O4@SiO2 nanoparticles as theranostic agents for simultaneous VEGF siRNA delivery and magnetic resonance cell imaging

2015 ◽  
pp. 4279 ◽  
Author(s):  
Yiyao Liu ◽  
Tingting Li ◽  
Xue Shen ◽  
Yin Chen ◽  
Chengchen Zhang ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Cell Imaging ◽  
Sirna Delivery ◽  
Sio2 Nanoparticles ◽  
Theranostic Agents ◽  
Resonance Cell

scholarly journals A new high pressure sapphire nuclear magnetic resonance cell

1996 ◽  
Vol 67 (1) ◽  
pp. 240-243 ◽  
Author(s):  
Shi Bai ◽  
Craig M. Taylor ◽  
Charles L. Mayne ◽  
Ronald J. Pugmire ◽  
David M. Grant
Keyword(s):  
Nuclear Magnetic Resonance ◽  
High Pressure ◽  
Magnetic Resonance ◽  
Resonance Cell ◽  
Nuclear Magnetic

Miniaturization of Magnetic Resonance Microsystem Components for 3D Cell Imaging

2007 ◽  
Author(s):  
Long-Sheng Fan ◽  
Shawn S. H. Hsu ◽  
Jun-De Jin ◽  
Cheng-Yu Hsieh ◽  
Wei-Chen Lin ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Cell Imaging

A mesoporous polydopamine nanoparticle enables highly efficient manganese encapsulation for enhanced MRI-guided photothermal therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Yan Wu ◽  
Yu Huang ◽  
Chunlai Tu ◽  
Fengren Wu ◽  
Gangsheng Tong ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Photothermal Therapy ◽  
Tumor Therapy ◽  
Resonance Imaging ◽  
Highly Efficient ◽  
Enhanced Mri ◽  
Mri Guided ◽  
Theranostic Agents ◽  
Magnetic Resonance Imaging Mri

Theranostic agents based on magnetic resonance imaging (MRI) and photothermal therapy (PTT) play an important role in tumor therapy. However, available theranostic agents are confronting great challenges in the issues...

scholarly journals Iron Oxide Incorporated Conjugated Polymer Nanoparticles for Simultaneous Use in Magnetic Resonance and Fluorescent Imaging of Brain Tumors

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1258
Author(s):  
N. Arias-Ramos ◽  
L. E. Ibarra ◽  
M. Serrano-Torres ◽  
B. Yagüe ◽  
M. D. Caverzán ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Conjugated Polymer ◽  
Colloidal Stability ◽  
Fluorescent Imaging ◽  
Polymer Nanoparticles ◽  
Biodistribution Studies ◽  
Conjugated Polymer Nanoparticles ◽  
Theranostic Agents

Conjugated polymer nanoparticles (CPNs) have emerged as advanced polymeric nanoplatforms in biomedical applications by virtue of extraordinary properties including high fluorescence brightness, large absorption coefficients of one and two-photons, and excellent photostability and colloidal stability in water and physiological medium. In addition, low cytotoxicity, easy functionalization, and the ability to modify CPN photochemical properties by the incorporation of dopants, convert them into excellent theranostic agents with multifunctionality for imaging and treatment. In this work, CPNs were designed and synthesized by incorporating a metal oxide magnetic core (Fe3O4 and NiFe2O4 nanoparticles, 5 nm) into their matrix during the nanoprecipitation method. This modification allowed the in vivo monitoring of nanoparticles in animal models using magnetic resonance imaging (MRI) and intravital fluorescence, techniques widely used for intracranial tumors evaluation. The modified CPNs were assessed in vivo in glioblastoma (GBM) bearing mice, both heterotopic and orthotopic developed models. Biodistribution studies were performed with MRI acquisitions and fluorescence images up to 24 h after the i.v. nanoparticles administration. The resulting IONP-doped CPNs were biocompatible in GBM tumor cells in vitro with an excellent cell incorporation depending on nanoparticle concentration exposure. IONP-doped CPNs were detected in tumor and excretory organs of the heterotopic GBM model after i.v. and i.t. injection. However, in the orthotopic GBM model, the size of the nanoparticles is probably hindering a higher effect on intratumorally T2-weighted images (T2WI) signals and T2 values. The photodynamic therapy (PDT)—cytotoxicity of CPNs was not either affected by the IONPs incorporation into the nanoparticles.

Sign in / Sign up

Export Citation Format

Share Document