scholarly journals Magnetic resonance imaging of folic acid-coated magnetite nanoparticles reflects tissue biodistribution of long-acting antiretroviral therapy

2015 ◽  
pp. 3779 ◽  
Author(s):  
Howard Gendelman ◽  
Tiznyuzi Li ◽  
Michael Boska ◽  
JoEllyn McMillan ◽  
Pavan Puligujja ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Folic Acid ◽  
Antiretroviral Therapy ◽  
Magnetic Resonance ◽  
Magnetite Nanoparticles ◽  
Resonance Imaging ◽  
Long Acting

Preparation of Gd-Au Dendrimer-Entrapped Gold Nanoparticles-Folic Acid Nanoparticles and Its Application in Computed Tomography/Magnetic Resonance Imaging Dual-Modality Diagnosis of Abdominal Tumors

2021 ◽  
Vol 13 (7) ◽  
pp. 1364-1373
Author(s):  
Yumei Zhang ◽  
Ruina Pei ◽  
Tao Luo
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Folic Acid ◽  
Magnetic Resonance ◽  
Receptor Expression ◽  
Average Particle ◽  
Resonance Imaging ◽  
Dual Modality ◽  
Abdominal Tumors

ABSTRACTThe development of nanomaterials, especially the development of multi-modality imaging nanoprobe technology has become a reality for tumor imaging diagnosis. In this study, the gadolinium ion chelating agent (2,2′,2′′-(10-(2-(2, 5-dioxopyrrolidin-1-oxyl)-2 oxoethyl)-1, 4, 7, 10-tetraazacyclododecane-1, 4, 7-tri)triacetic acid) (DOTA-NHS) and polyethylene glycol (PEG)-modified targeting ligand PEG-folic acid (FA) were grafted onto the PEG-modified fifth-generation polyamide-amine dendrimer (P5-NH2), which were undertaken as standards to wrap gold nanoparticles. Then, remaining amino group was acetylated to acquire Gd–Au DENPS-FA nanoparticles. Biocompatibility and cytotoxicity of nanoparticles were analyzed while characterizing them. The cases with unidentified tumors (mass diameter >4.5 cm) of abdominal or pelvic origin were selected and used for clinical study of computed tomography (CT)/magnetic resonance imaging (MRI) dual-modality abdominal tumors. In the test, average particle size of Gd-Au DENPs-FA nanoparticles was 4.2 nm, and they had good water solubility and stability in aqueous solution. When concentration of Au+ nanoparticles increased, the cell morphology remained normal, only a small number of round cells appeared, and the cell activity remained above 80%. GD-Au DENPs-FA nanoparticles had a good targeting specificity for KB cells with high folate receptor expression. During 6–24 hours of injection, the signal at the tumor site of the patient was enhanced markedly, namely the targeted gold nanoparticles were bound to the tumor tissue and the metabolic rate was slow. Based on this material, CT/MRI imaging could be performed in the patient’s body and further used for the early diagnosis of abdominal tumors.

Bevacizumab and folic acid dual-targeted gadolinium-carbon dots for fluorescence/magnetic resonance imaging of hepatocellular carcinoma

2021 ◽  
Vol 61 ◽  
pp. 102288
Author(s):  
Fatemeh Maghsoudinia ◽  
Mohamad Bagher Tavakoli ◽  
Roghayeh Kamran Samani ◽  
Hasan Motaghi ◽  
Seyed Hossein Hejazi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Hepatocellular Carcinoma ◽  
Folic Acid ◽  
Magnetic Resonance ◽  
Carbon Dots ◽  
Resonance Imaging

Water-Soluble Superparamagnetic Magnetite Nanoparticles with Biocompatible Coating for Enhanced Magnetic Resonance Imaging

ACS Nano ◽  
2011 ◽  
Vol 5 (8) ◽  
pp. 6315-6324 ◽  
Author(s):  
Lisong Xiao ◽  
Jiangtian Li ◽  
Dermot F. Brougham ◽  
Eoin K. Fox ◽  
Neus Feliu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Magnetite Nanoparticles ◽  
Water Soluble ◽  
Resonance Imaging ◽  
Biocompatible Coating

Hyperbranched poly(glycerol) as a T1 contrast agent for tumor-targeted magnetic resonance imaging in vivo

2017 ◽  
Vol 8 (6) ◽  
pp. 1104-1113 ◽  
Author(s):  
Yi Cao ◽  
Min Liu ◽  
Guangyue Zu ◽  
Ye Kuang ◽  
Xiaoyan Tong ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Folic Acid ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Resonance Imaging ◽  
One Pot ◽  
Hyperbranched Poly ◽  
T1 Contrast Agent ◽  
T1 Contrast

To explore a convenient and efficient strategy for constructing tumor-targeted T1 mCAs for MRI, hyperbranched poly(glycerol) prepared in one-pot was used to conjugate gadolinium chelates and folic acid ligands through “click chemistry”.

scholarly journals Magnetic Resonance Imaging Property of Doxorubicin-Loaded Gadolinium/13X Zeolite/Folic Acid Nanocomposite

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
S Ghaderi
Keyword(s):  
Magnetic Resonance Imaging ◽  
Folic Acid ◽  
Magnetic Resonance ◽  
Relaxation Times ◽  
A549 Cells ◽  
In Vitro Study ◽  
Resonance Imaging ◽  
13X Zeolite ◽  
Magnetic Resonance Imaging Mri

Abstract Background: Magnetic resonance imaging (MRI) using nanostructures has been a proper method for tumor targeting purposes. Different MRI nanomaterials, targeting agents and anticancer drugs have been used for targeting of tumors. Objectives: This study aims to consider the MRI property of doxorubicin (DOX)-loaded gadolinium/13X zeolite/folic acid (Gd3+/13X/FA) nanocomposite. Material and Methods: In this in vitro study, Gd3+/13X/FA/DOX nanocomposite was prepared and the X-ray diffraction, scanning electron microscopy and MTT assay were conducted to evaluate the physicochemical properties of the nanocomposite. MRI was performed at 25°C using a 1.5 T clinical system to determine the T1 relaxation times and subsequently, the T1 relaxivity. Results: The size of the nanocomposite was in the range of 80-200 nm. The nanocomposite without DOX loading (Gd3+/13X/FA) showed compatibility for A549 cells for all concentrations while DOX-loaded nanocomposite was toxic for 62% of the cells at the concentration of 0.4 mg/ml. The T1 relaxivity of Gd3+/13X/FA/DOX nanocomposite was 4.0401 mM-1s-1. Conclusion: Gd3+/13X/FA/DOX nanocomposite shows a T1 relaxivity similar to the conventional gadolinium chelates, and a successful DOX loading.

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