scholarly journals Synergistic effect of pH-responsive folate-functionalized poloxamer 407-TPGS-mixed micelles on targeted delivery of anticancer drugs

2015 ◽  
pp. 1321 ◽  
Author(s):  
Mohd Cairul Iqbal Mohd Amin ◽  
Adeel Masood Butt ◽  
Haliza Katas
Keyword(s):  
Synergistic Effect ◽  
Anticancer Drugs ◽  
Targeted Delivery ◽  
Mixed Micelles ◽  
Poloxamer 407 ◽  
Ph Responsive ◽  
Effect Of Ph

Synergistic effect of pH-responsive wormlike micelles based on a simple amphiphile

Soft Matter ◽  
2016 ◽  
Vol 12 (20) ◽  
pp. 4549-4556 ◽  
Author(s):  
Xuepeng Wu ◽  
Yining Wu ◽  
Shuai Yang ◽  
Mingwei Zhao ◽  
Mingwei Gao ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Wormlike Micelles ◽  
Ph Responsive ◽  
Effect Of Ph

Facile green synthesis of calcium carbonate/folate porous hollow spheres for the targeted pH-responsive release of anticancer drugs

2016 ◽  
Vol 4 (34) ◽  
pp. 5650-5653 ◽  
Author(s):  
Yuming Guo ◽  
Weili Jia ◽  
Han Li ◽  
Weike Shi ◽  
Jie Zhang ◽  
...  
Keyword(s):  
Calcium Carbonate ◽  
Sustained Release ◽  
Green Synthesis ◽  
Anticancer Drugs ◽  
Targeted Delivery ◽  
Hollow Spheres ◽  
Ph Responsive

Calcium carbonate/folate porous hollow spheres were prepared in a facile manner and used for the targeted delivery and pH-responsive sustained release of anticancer drugs.

scholarly journals Development and Evaluation of Multifunctional Poly(Lactic-co-glycolic acid) Nanoparticles Embedded in Carboxymethyl β-Glucan Porous Microcapsules as a Novel Drug Delivery System for Gefitinib

Pharmaceutics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 469 ◽  
Author(s):  
Xiaonan Li ◽  
Jinglei Wang ◽  
Shang Li ◽  
Zhaorong Liu ◽  
Zhiru Zheng ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Targeted Delivery ◽  
Glycolic Acid ◽  
Lung Tumor ◽  
A549 Cells ◽  
Amorphous State ◽  
Poloxamer 407 ◽  
Hydrodynamic Diameter ◽  
Prolonged Release ◽  
Ph Responsive

In this study, a new kind of folic acid (FA)-conjugated and chitosan (CS)-coated poloxamer 407 (P407)/poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs), FCPP NPs, were prepared, and further micro-encapsulated by carboxymethyl β-glucan microcapsules (MCs) to produce a multifunctional system of NPs embedded in MCs (NEMs) for potential lung tumor-targeted delivery of gefitinib. The prepared gefitinib-loaded FCPP (GFB/FCPP) NPs showed a hydrodynamic diameter of 255.4 ± 14.5 nm and existed in an amorphous state. After encapsulation in carboxymethyl β-glucan MCs, the GFB/FCPP-based NEMs (GFB/FCPP-NEMs) also exhibited a spherical morphology with a median diameter (d50) of around 2.2 μm. After hydration, GFB/FCPP- NEMs can quickly dissociate into its primary particles, GFB/FCPP NPs. Our in vitro drug release study revealed that these GFB/FCPP-NEMs exhibited a pH-responsive prolonged release property. In addition, the cellular uptake study demonstrated that FCPP-NEMs serve as an efficient carrier to enhance the delivery of the entrapped drug into the target lung tumor cells. Moreover, the GFB/FCPP-NEMs induced a superior cytotoxic effect compared with free gefitinib. The inhibitory concentration to achieve 50% cell death (IC50) of GFB/FCPP-NEMs in A549 cells was 3.82-fold lower than that of free gefitinib. According to these results, FCPP-NEMs hold a great potential as a multifunctional and high-performance biomaterial for lung tumor targeting delivery, pH-responsive sustained release, facilitated cellular uptake, and enhanced antitumor effect of antitumor drugs, like gefitinib.

Targeted Delivery of Dual Anticancer Drugs Based on Self-Assembled iRGD-Modified Soluble Drug–Polymer Pattern Conjugate Nanoparticles

2021 ◽  
Vol 4 (2) ◽  
pp. 1499-1507
Author(s):  
Chunxiao Li ◽  
Zhenyu Chen ◽  
Dan Zheng ◽  
Jingyang Zhao ◽  
Jiandu Lei
Keyword(s):  
Anticancer Drugs ◽  
Targeted Delivery ◽  
Self Assembled

scholarly journals Self-Assembling pH-Responsive Nanoparticle Platform Based on Pectin–Doxorubicin Conjugates for Codelivery of Anticancer Drugs

ACS Omega ◽  
2021 ◽  
Author(s):  
Yinghua Tao ◽  
Dan Zheng ◽  
Jingyang Zhao ◽  
Kefeng Liu ◽  
Jing Liu ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Ph Responsive ◽  
Self Assembling

Synthesis of surface functionalized hollow microporous organic capsules for doxorubicin delivery to cancer cells

2020 ◽  
Vol 11 (12) ◽  
pp. 2110-2118 ◽  
Author(s):  
Shumaila Razzaque ◽  
Ying Cheng ◽  
Irshad Hussain ◽  
Bien Tan
Keyword(s):  
Cancer Cells ◽  
Anticancer Drugs ◽  
Targeted Delivery ◽  
Potential Applications ◽  
Doxorubicin Delivery

Functionalized hypercrosslinked hollow microporous capsules are demonstrated to have potential applications in targeted delivery of anticancer drugs.

Sign in / Sign up

Export Citation Format

Share Document