scholarly journals Optimizing stem cell functions and antibacterial properties of TiO2 nanotubes incorporated with ZnO nanoparticles: experiments and modeling

2015 ◽  
pp. 1997 ◽  
Author(s):  
Wenwen Liu ◽  
Penglei Su ◽  
Arthur Gonzales ◽  
Na Wang ◽  
Zhenting Zhang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Zno Nanoparticles ◽  
Tio2 Nanotubes ◽  
Antibacterial Properties ◽  
Cell Functions

Synthesis of TiO2 nanotubes with ZnO nanoparticles to achieve antibacterial properties and stem cell compatibility

Nanoscale ◽  
2014 ◽  
Vol 6 (15) ◽  
pp. 9050-9062 ◽  
Author(s):  
Wenwen Liu ◽  
Penglei Su ◽  
Su Chen ◽  
Na Wang ◽  
Yuanping Ma ◽  
...  
Keyword(s):  
Stem Cell ◽  
Streptococcus Mutans ◽  
Zno Nanoparticles ◽  
Bacterial Adhesion ◽  
Tio2 Nanotubes ◽  
Antibacterial Properties ◽  
Cell Compatibility

ZnO incorporated Ti samples inhibited the expression of Streptococcus mutans bacterial adhesion genes and also inhibited P. gingivalis proliferation. (a) S. mutans and (b) P. gingivalis on the sample of TNT–Zn0.075.

Metabolic Regulation and Related Molecular Mechanisms in Various Stem Cell Functions

2020 ◽  
Vol 15 (6) ◽  
pp. 531-546 ◽  
Author(s):  
Hwa-Yong Lee ◽  
In-Sun Hong
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Oxidative Phosphorylation ◽  
Metabolic Pathways ◽  
Critical Role ◽  
The Self ◽  
Specific Cell ◽  
Differentiation Potential ◽  
Self Renewal ◽  
Cell Functions

Recent studies on the mechanisms that link metabolic changes with stem cell fate have deepened our understanding of how specific metabolic pathways can regulate various stem cell functions during the development of an organism. Although it was originally thought to be merely a consequence of the specific cell state, metabolism is currently known to play a critical role in regulating the self-renewal capacity, differentiation potential, and quiescence of stem cells. Many studies in recent years have revealed that metabolic pathways regulate various stem cell behaviors (e.g., selfrenewal, migration, and differentiation) by modulating energy production through glycolysis or oxidative phosphorylation and by regulating the generation of metabolites, which can modulate multiple signaling pathways. Therefore, a more comprehensive understanding of stem cell metabolism could allow us to establish optimal culture conditions and differentiation methods that would increase stem cell expansion and function for cell-based therapies. However, little is known about how metabolic pathways regulate various stem cell functions. In this context, we review the current advances in metabolic research that have revealed functional roles for mitochondrial oxidative phosphorylation, anaerobic glycolysis, and oxidative stress during the self-renewal, differentiation and aging of various adult stem cell types. These approaches could provide novel strategies for the development of metabolic or pharmacological therapies to promote the regenerative potential of stem cells and subsequently promote their therapeutic utility.

Preparation of polycrystalline ZnO nanoparticles loaded onto graphene oxide and their antibacterial properties

2021 ◽  
pp. 102531
Author(s):  
Xin Zhang ◽  
Huanxian Shi ◽  
Enzhou Liu ◽  
Xiaoyun Hu ◽  
Ke Zhang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Zno Nanoparticles ◽  
Antibacterial Properties

scholarly journals GSK3β, a Master Kinase in the Regulation of Adult Stem Cell Behavior

Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 225
Author(s):  
Claire Racaud-Sultan ◽  
Nathalie Vergnolle
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Adult Stem Cells ◽  
Glycogen Synthase ◽  
Inflammatory Diseases ◽  
Adult Stem Cell ◽  
Leukemic Cells ◽  
Cell Phenotype ◽  
Epithelial Regeneration ◽  
Cell Functions

In adult stem cells, Glycogen Synthase Kinase 3β (GSK3β) is at the crossroad of signaling pathways controlling survival, proliferation, adhesion and differentiation. The microenvironment plays a key role in the regulation of these cell functions and we have demonstrated that the GSK3β activity is strongly dependent on the engagement of integrins and protease-activated receptors (PARs). Downstream of the integrin α5β1 or PAR2 activation, a molecular complex is organized around the scaffolding proteins RACK1 and β-arrestin-2 respectively, containing the phosphatase PP2A responsible for GSK3β activation. As a consequence, a quiescent stem cell phenotype is established with high capacities to face apoptotic and metabolic stresses. A protective role of GSK3β has been found for hematopoietic and intestinal stem cells. Latters survived to de-adhesion through PAR2 activation, whereas formers were protected from cytotoxicity through α5β1 engagement. However, a prolonged activation of GSK3β promoted a defect in epithelial regeneration and a resistance to chemotherapy of leukemic cells, paving the way to chronic inflammatory diseases and to cancer resurgence, respectively. In both cases, a sexual dimorphism was measured in GSK3β-dependent cellular functions. GSK3β activity is a key marker for inflammatory and cancer diseases allowing adjusted therapy to sex, age and metabolic status of patients.

scholarly journals Antibacterial activity of zinc oxide nanoparticles obtained by pulsed laser ablation in water and air

2018 ◽  
Vol 243 ◽  
pp. 00017 ◽  
Author(s):  
Daria Goncharova ◽  
Ekaterina Gavrilenko ◽  
Anna Nemoykina ◽  
Valery Svetlichnyi
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Antibacterial Activity ◽  
Laser Ablation ◽  
Zno Nanoparticles ◽  
Antibacterial Properties ◽  
Pulsed Laser ◽  
Pulsed Laser Ablation ◽  
Composition And Structure ◽  
Scanning Electron

The paper studies physicochemical and antibacterial properties of ZnO nanoparticles obtained by pulsed laser ablation in water and air. Their composition and structure were studied by X-ray diffraction, transmission and scanning electron microscopy. Antibacterial activity of the nanoparticles was examined by its affection on Gram-positive Staphylococcus aureus (S.aureus). The dependence of nanoparticles’ physical and chemical antibacterial properties on the conditions of the ablation was shown. The model materials for the antibacterial bandage were made of cotton, filter paper and biodegradable polymer scaffolds (poly-l-lactide acid), and then they were coated with the obtained ZnO nanoparticles. The model bandage materials were examined by the scanning electron microscopy method and their antibacterial activity (ISO 20743:2013) was determined. High activity of all the samples against S.aureus was proved.

scholarly journals Synthesis of Chitosan/Zinc Oxide Nanoparticles Stabilized by Chitosan via Microwave Heating

2019 ◽  
Vol 14 (2) ◽  
pp. 450 ◽  
Author(s):  
Nurul Amira Ahmad Yusof ◽  
Norashikin Mat Zain ◽  
Norlin Pauzi
Keyword(s):  
Zinc Oxide ◽  
Microwave Heating ◽  
Zno Nanoparticles ◽  
Bacterial Infections ◽  
Pathogenic Bacteria ◽  
Antibacterial Properties ◽  
Inhibition Zone ◽  
Mean Value ◽  
Average Crystalline Size ◽  
Xrd Patterns

Nowadays, zinc oxide (ZnO) has attracted attention in research and development because of its remarkable antibacterial properties. Chitosan/ZnO nanoparticles were successfully synthesized via microwave heating. The objectives of this work were to investigate the effect of stabilizer, power heating and time heating on size of chitosan/ZnO nanoparticles and to determine antibacterial activity against pathogenic bacteria, where chitosan was used as a stabilizing agent. Chitosan/ZnO nanoparticles were analyzed  by Fourier Transform Infra Red (FTIR), X-ray Diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM), and Zetasizer instrument. The power heating and time heating were varied from 400 to 800 Watt and 4 to 8 minutes, respectively. The presence of chitosan has role on preventing the nanoparticles from agglomeration by producing a milky solution of chitosan/ZnO nanoparticles without any suspensions. The increase of power  and time heating improved the size of nanoparticles. The peak in FTIR spectrum at around 427 cm-1 was confirmed the existence of the ZnO phase. XRD patterns showed that the chitosan/ZnO nanoparticles materials were pure phase with average crystalline size is 130 nm. FESEM revealed that chitosan/ZnO nanoparticles were uniformly distributed with the mean value of size is 70 nm and spherical shaped. Further impact of power and time heating on the size of the chitosan/ZnO nanoparticles can be shown by a nanoparticles size distribution with the average of 30 to 90 nm. The results showed that chitosan/ZnO nanoparticles have displayed an antibacterial inhibition zone against Gram-positive S. aureus and Gram-negative E. coli which 16.0 and 13.3 mm, respectively. Chitosan/ZnO nanoparticles were synthesized in this work presented have potential application to prevent bacterial infections. Copyright © 2019 BCREC Group. All rights reserved 

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