scholarly journals Carboxyl-modified single-wall carbon nanotubes improve bone tissue formation in vitro and repair in an in vivo rat model

2014 ◽  
pp. 4277 ◽  
Author(s):  
Antonio Barrientos-Duran ◽  
Ellen M. Carpenter ◽  
Nicole I. zur Nieden ◽  
Theodore I. Malinin ◽  
Juan Carlos Rodriguez-Manzaneque ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Bone Tissue ◽  
Rat Model ◽  
Single Wall Carbon Nanotubes ◽  
Tissue Formation ◽  
Single Wall Carbon ◽  
Bone Tissue Formation

Carbon Nanotube Reinforced Collagen/Hydroxyapatite Scaffolds Improve Bone Tissue Formation In Vitro and In Vivo

2017 ◽  
Vol 45 (9) ◽  
pp. 2075-2087 ◽  
Author(s):  
Zheng Jing ◽  
Yeke Wu ◽  
Wen Su ◽  
Mi Tian ◽  
Wenlu Jiang ◽  
...  
Keyword(s):  
Carbon Nanotube ◽  
Bone Tissue ◽  
Tissue Formation ◽  
Bone Tissue Formation

Evaluation of the genotoxic potential of single-wall carbon nanotubes by using a battery of in vitro and in vivo genotoxicity assays

2011 ◽  
Vol 61 (2) ◽  
pp. 192-198 ◽  
Author(s):  
Masato Naya ◽  
Norihiro Kobayashi ◽  
Kohei Mizuno ◽  
Kyomu Matsumoto ◽  
Makoto Ema ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Single Wall Carbon Nanotubes ◽  
Single Wall Carbon ◽  
Genotoxic Potential

In vivo genotoxicity study of single-wall carbon nanotubes using comet assay following intratracheal instillation in rats

2012 ◽  
Vol 64 (1) ◽  
pp. 124-129 ◽  
Author(s):  
Masato Naya ◽  
Norihiro Kobayashi ◽  
Shigehisa Endoh ◽  
Junko Maru ◽  
Kazumasa Honda ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Comet Assay ◽  
Intratracheal Instillation ◽  
Single Wall Carbon Nanotubes ◽  
Single Wall Carbon

Bioactive and Biocompatible Silica/Pseudowollastonite Aerogels

2014 ◽  
Vol 96 ◽  
pp. 21-26 ◽  
Author(s):  
P.J. Reséndiz-Hernández ◽  
D.A. Cortés-Hernández ◽  
Juan Méndez Nonell ◽  
J.C. Escobedo-Bocardo
Keyword(s):  
Bone Tissue ◽  
Ambient Pressure ◽  
Sol Gel ◽  
Ambient Pressure Drying ◽  
Bone Tissue Regeneration ◽  
Tissue Formation ◽  
Potential Applications ◽  
Ft Ir ◽  
Bone Tissue Formation

Silica aerogels have attracted increasingly more attention due to their extraordinary properties and their existing and potential applications in a wide variety of technological areas. Materials that promote bone-tissue formation at their surface and bond to osseous tissues when implanted are called bioactive, such as pseudowollastonite particles. In this work, the synthesis of aerogels with pseudowollastonite particles was performed. The synthesis involved the preparation of an alcogel by a two step sol-gel route followed by ambient pressure drying. To promote a higher bioactivity the obtained aerogels were then biomimetically treated using simulated body fluids, SBF and 1.5 SBF. A high bioactivity was demonstrated by FT-IR, SEM, EDS, and XRD. The in vitro biocompatibility was assessed by testing cytotoxicity using rat osteoblasts cultures. The results obtained indicate that these materials are highly potential aerogels for bone tissue regeneration.

The combination of nanofibrous and microfibrous materials for enhancement of cell infiltration and in vivo bone tissue formation

2018 ◽  
Vol 13 (2) ◽  
pp. 025004 ◽  
Author(s):  
M Rampichová ◽  
J Chvojka ◽  
V Jenčová ◽  
T Kubíková ◽  
Z Tonar ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Cell Infiltration ◽  
Tissue Formation ◽  
Bone Tissue Formation

scholarly journals Conductive single-wall carbon nanotubes/extracellular matrix hybrid hydrogels promote the lineage-specific development of seeding cells for tissue repair through reconstructing an integrin-dependent niche

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Rui Bai ◽  
Jianfeng Liu ◽  
Jiao Zhang ◽  
Jinmiao Shi ◽  
Zhigeng Jin ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Stem Cells ◽  
Extracellular Matrix ◽  
Tissue Repair ◽  
Single Wall Carbon Nanotubes ◽  
Hybrid Hydrogel ◽  
Hybrid Hydrogels ◽  
Biophysical Cues

Abstract Background The niche of tissue development in vivo involves the growth matrix, biophysical cues and cell-cell interactions. Although natural extracellular matrixes may provide good supporting for seeding cells in vitro, it is evitable to destroy biophysical cues during decellularization. Reconstructing the bioactivities of extracellular matrix-based scaffolds is essential for their usage in tissue repair. Results In the study, a hybrid hydrogel was developed by incorporating single-wall carbon nanotubes (SWCNTs) into heart-derived extracellular matrixes. Interestingly, insoluble SWCNTs were well dispersed in hybrid hydrogel solution via the interaction with extracellular matrix proteins. Importantly, an augmented integrin-dependent niche was reconstructed in the hybrid hydrogel, which could work like biophysical cues to activate integrin-related pathway of seeding cells. As supporting scaffolds in vitro, the hybrid hydrogels were observed to significantly promote seeding cell adhesion, differentiation, as well as structural and functional development towards mature cardiac tissues. As injectable carrier scaffolds in vivo, the hybrid hydrogels were then used to delivery stem cells for myocardial repair in rats. Similarly, significantly enhanced cardiac differentiation and maturation(12.5 ± 2.3% VS 32.8 ± 5%) of stem cells were detected in vivo, resulting in improved myocardial regeneration and repair. Conclusions The study represented a simple and powerful approach for exploring bioactive scaffold to promote stem cell-based tissue repair. Graphic abstract

scholarly journals Evaluation of the Skin Sensitization Potential of Carbon Nanotubes Using Alternative In Vitro and In Vivo Assays

Toxics ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 122
Author(s):  
Sung-Hyun Kim ◽  
Dong Han Lee ◽  
Jin Hee Lee ◽  
Jun-Young Yang ◽  
Hyo-Sook Shin ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Large Scale ◽  
Test Method ◽  
Single Wall Carbon Nanotubes ◽  
Scale Production ◽  
Skin Sensitization ◽  
Alternative Test ◽  
Alternative Test Method

Carbon nanotubes (CNTs) are one of the major types of nanomaterials that have various industrial and biomedical applications. However, there is a risk of accidental exposure to CNTs in individuals involved in their large-scale production and in individuals who use products containing CNTs. This study aimed to evaluate the skin sensitization induced by CNTs using two alternative tests. We selected single-wall carbon nanotubes and multi-walled carbon nanotubes for this study. First, the physiochemical properties of the CNTs were measured, including the morphology, size, and zeta potential, under various conditions. Thereafter, we assessed the sensitization potential of the CNTs using the ARE-Nrf2 Luciferase KeratinoSens™ assay, an in vitro alternative test method. In addition, the CNTs were evaluated for their skin sensitization potential using the LLNA: BrdU-FCM in vivo alternative test method. In this study, we report for the first time the sensitization results of CNTs using the KeratinoSens™ and LLNA: BrdU-FCM test methods in this study. This study found that both CNTs do not induce skin sensitization. These results suggest that the KeratinoSens™ and LLNA: BrdU-FCM assay may be useful as alternative assays for evaluating the potential of some nanomaterials that can induce skin sensitization.

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