scholarly journals Evaluation of silica nanoparticle toxicity after topical exposure for 90 days

2014 ◽  
pp. 127 ◽  
Author(s):  
Seong Soo A. An ◽  
Hwa Jung Ryu ◽  
Nak-Won Seong ◽  
Byoung Joon So ◽  
Heung-Sik Seo ◽  
...  
Keyword(s):  
Silica Nanoparticle ◽  
Nanoparticle Toxicity

Influence of shape, adhension and simulated lung mechanics on amorphous silica nanoparticle toxicity

2007 ◽  
Vol 18 (1) ◽  
pp. 69-79 ◽  
Author(s):  
Scott C. Brown ◽  
Mohammed Kamal ◽  
Najmunnisa Nasreen ◽  
Aidos Baumuratov ◽  
Parvesh Sharma ◽  
...  
Keyword(s):  
Amorphous Silica ◽  
Silica Nanoparticle ◽  
Lung Mechanics ◽  
Nanoparticle Toxicity

Effect of polymer grafting density on silica nanoparticle toxicity

2012 ◽  
Vol 20 (23) ◽  
pp. 6862-6869 ◽  
Author(s):  
I-Chun Lin ◽  
Mingtao Liang ◽  
Tzu-Yu Liu ◽  
Zhongfan Jia ◽  
Michael J. Monteiro ◽  
...  
Keyword(s):  
Silica Nanoparticle ◽  
Polymer Grafting ◽  
Nanoparticle Toxicity ◽  
Grafting Density

scholarly journals Processing Pathway Dependence of Amorphous Silica Nanoparticle Toxicity: Colloidal vs Pyrolytic

2012 ◽  
Vol 134 (38) ◽  
pp. 15790-15804 ◽  
Author(s):  
Haiyuan Zhang ◽  
Darren R. Dunphy ◽  
Xingmao Jiang ◽  
Huan Meng ◽  
Bingbing Sun ◽  
...  
Keyword(s):  
Amorphous Silica ◽  
Silica Nanoparticle ◽  
Nanoparticle Toxicity

Application of Silica Nanoparticles in the Determination of Herbicides in Environmental Water Samples Using Liquid Chromatography-Mass Spectroscopy

2020 ◽  
Vol 16 (5) ◽  
pp. 748-756
Author(s):  
Mir Waqas Alam ◽  
Tentu Nageswara Rao ◽  
Yarasani Prashanthi ◽  
Vourse Sridhar ◽  
Adil Alshoaibi ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Liquid Chromatography ◽  
Silica Nanoparticles ◽  
Solid Phase ◽  
Silica Nanoparticle ◽  
Environmental Water ◽  
Phase Extraction ◽  
Functionalized Nanoparticles ◽  
Supporting Material

Background: Herbicides are very beneficial in the crop yield with the aid of controlling weeds within the agriculture, but several herbicides are chronic in soil. Objective: In this study, nanoparticles and the packages of synthesized novel silica nanoparticles were studied for the preconcentration of herbicides. Methods: These nanoparticles prepared by the Stöber mechanism were purified and functionalized. Nanoparticles thus prepared successfully were used as supporting material for the preconcentration of residues of herbicides in the water. Results: Preconcentration was achieved by preparing the silica-based solid-phase-extraction cartridges. Nanoparticles used for this purpose were within the range of 50-250 nm. An SPE cartridge was prepared by packing 200 mg of silica nanoparticle in the empty cartridge of diameter 5.5 cm and length 0.6 cm in between PTFE frits. Aqueous solutions of 0.1 μg/ml of herbicides were prepared separately, and 10 ml of the solution was passed through the cartridge at the rate of 0.2 ml/min. After passing 10 ml volume of the aqueous solution, residues adsorbed on the cartridge were eluted using 2 ml of acetonitrile. The eluate was injected to determine the herbicide residue adsorbed on the SPE cartridge. Conclusion: In the study, it was found that greater than 90% of the herbicide residues were trapped on silica nanoparticle-based SPE cartridge. An analytical method was developed for the simultaneous determination of these herbicides. The residues were quantified by LC-MS/MS with ESI mode.

Mesoporous Silica Nanoparticles of Hydroxyurea: Potential

2020 ◽  
Vol 10 ◽  
Author(s):  
Kumar Nishchaya ◽  
Swatantra K.S. Kushwaha ◽  
Awani Kumar Rai
Keyword(s):  
Drug Release ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Average Particle Size ◽  
Silica Nanoparticle ◽  
Average Particle ◽  
Independent Variables ◽  
Lower Temperature

Background: Present malignant cancer medicines has the advancement of magnetic nanoparticles as delivery carriers to magnetically accumulate anticancer medication in malignant growth tissue. Aim: In the present investigation, a silica nanoparticles (MSNs) stacked with hydroxyurea were combined and was optimized for dependent and independent variables. Method: In this study, microporous silica nanoparticle stacked with neoplastic medication had been prepared through emulsification followed with solvent evaporation method. Prepared MSNs were optimized for dependent and independent variables. Different formulations were prepared with varying ratio of polymer, lipid and surfactant which affects drug release and kinetics of drug release pattern. The obtained MSNs were identified by FTIR, SEM, drug entrapment, in-vitro drug release, drug release kinetics study, stability testing in order to investigate the nanoparticle characteristics. Results: The percentage drug entrapment of the drug for the formulations F1, F2, F3, was found to be 27.78%, 65.52% and 48.26%. The average particle size for F2 formulation was found to be 520 nm through SEM. The cumulative drug release for the formulations F1, F2, F3 was found to be 64.17%, 71.82% and 32.68%. The formulations were found to be stable which gives controlled drug delivery for 6 hours. Conclusion: From the stability studies data it can be culminated that formulations are most stable when stored at lower temperature or in refrigerator i.e. 5˚C ± 3˚C. It can be concluded that MSN’s loaded with hydroxyurea is a promising approach towards the management of cancer due to its sustained release and less side effects.

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