scholarly journals Biomechanical stability of a bioabsorbable self-retaining polylactic acid/nano-sized β-tricalcium phosphate cervical spine interbody fusion device in single-level anterior cervical discectomy and fusion sheep models

2012 ◽  
pp. 5875 ◽  
Author(s):  
Lu Cao ◽  
Duan ◽  
Li ◽  
Yuan ◽  
Ming-Dong Zhao ◽  
...  
Author(s):  
Denis J. DiAngelo ◽  
Amanda L. Thomas ◽  
Kevin T. Foley

Anterior cervical graft fusion alone or supplemented with an anterior cervical plate instrumentation may be used to treat the diseased cervical spine. An anterior cervical plate is intended to restore the mechanical integrity of the operated spine and decrease graft complications. An alternative method to single-level graft fusion is to use an interbody fusion device. The objective of this study was to compare the biomechanical stability of a single-level graft-plated cervical construct with an interbody cage device.


2021 ◽  
Author(s):  
Lynn M. Pezzanite ◽  
Jeremiah T. Easley ◽  
Rosemary Bayless ◽  
Ellison Aldrich ◽  
Brad B. Nelson ◽  
...  

2020 ◽  
Author(s):  
Jun Zhang ◽  
Xiangyu Tang ◽  
Wei Xiong ◽  
Hua Wu ◽  
Chaoxu Liu ◽  
...  

Abstract Purpose This study was to compare the clinical outcomes, radiographic parameters, and complications of anterior cervical discectomy and fusion (ACDF) with a Zero-profile implant (Zero-P) and traditional plate and cage. Methods There were 68 patients received ACDF of single level, 35 patients with Zero-profile implant (Zero-p group) and 33 patients with traditional plate and cage (Cage group), from C3–C7 during 2014 to 2016. Collecting and analyzing of clinical and radiological data were performed. Patients were followed-up at least 1 year after surgery. The operation time, blood loss, Japan Department of Orthopedics Association (JOA) score, pain Visual Analogue Score (VAS), Neck Disability Index (NDI) score and dysphagia score were recorded. Additionally, changes in cervical lordosis, fusion rate and adjacent segment degeneration were analyzed as well. Results For neurologic outcomes, the JOA, VAS and NDI were statistically equivalent between the two groups (P>0.05). For radiographic outcomes, there were no significant differences in the C2-7 Cobb angles, segmental Cobb angle and incidence of subsidence at the final follow-up (P>0.05). No degenerative changes was found in the Zero-p group, whereas 5 patients in the Cage group developed degeneration in adjacent segments (P<0.05). Also, the incidence of postoperative dysphagia is higher in Cage group than in Zero-p group at 3 months and 12 months (P<0.05). Conclusions Both Zero-profile implant and anterior cervical plate interbody fusion device were demonstrated to be effective and safe strategies in this study. Considering the lower incidences of dysphagia and degenerative changes, the Zero-profile implant is a good succedaneum.


Spine ◽  
1996 ◽  
Vol 21 (10) ◽  
pp. 1201-1210 ◽  
Author(s):  
Harvinder S. Sandhu ◽  
Simon Turner ◽  
J. Michael Kabo ◽  
Linda E. A. Kanim ◽  
David Liu ◽  
...  

2016 ◽  
Vol 105 (5) ◽  
pp. 1157-1168
Author(s):  
Alexander C. M. Chong ◽  
Seth W. Harrer ◽  
Michael H. Heggeness ◽  
Paul H. Wooley

2021 ◽  
Vol 50 (6) ◽  
pp. E6
Author(s):  
Stephen M. Bergin ◽  
Timothy Y. Wang ◽  
Christine Park ◽  
Shashank Rajkumar ◽  
C. Rory Goodwin ◽  
...  

OBJECTIVE The use of osteobiologics, engineered materials designed to promote bone healing by enhancing bone growth, is becoming increasingly common for spinal fusion procedures, but the efficacy of some of these products is unclear. The authors performed a retrospective, multi-institutional study to investigate the clinical and radiographic characteristics of patients undergoing single-level anterior cervical discectomy with fusion performed using the osteobiologic agent Osteocel, an allograft mesenchymal stem cell matrix. METHODS The medical records across 3 medical centers and 12 spine surgeons were retrospectively queried for patients undergoing single-level anterior cervical discectomy and fusion (ACDF) with the use of Osteocel. Pseudarthrosis was determined based on CT or radiographic imaging of the cervical spine. Patients were determined to have radiographic pseudarthrosis if they met any of the following criteria: 1) lack of bridging bone on CT obtained > 300 days postoperatively, 2) evidence of instrumentation failure, or 3) motion across the index level as seen on flexion-extension cervical spine radiographs. Univariate and multivariate analyses were then performed to identify independent preoperative or perioperative predictors of pseudarthrosis in this population. RESULTS A total of 326 patients met the inclusion criteria; 43 (13.2%) patients met criteria for pseudarthrosis, of whom 15 (34.9%) underwent revision surgery. There were no significant differences between patients with and those without pseudarthrosis, respectively, for patient age (54.1 vs 53.8 years), sex (34.9% vs 47.4% male), race, prior cervical spine surgery (37.2% vs 33.6%), tobacco abuse (16.3% vs 14.5%), chronic kidney disease (2.3% vs 2.8%), and diabetes (18.6% vs 14.5%) (p > 0.05). Presence of osteopenia or osteoporosis (16.3% vs 3.5%) was associated with pseudarthrosis (p < 0.001). Implant type was also significantly associated with pseudarthrosis, with a 16.4% rate of pseudarthrosis for patients with polyetherethereketone (PEEK) implants versus 8.4% for patients with allograft implants (p = 0.04). Average lengths of follow-up were 27.6 and 23.8 months for patients with and those without pseudarthrosis, respectively. Multivariate analysis demonstrated osteopenia or osteoporosis (OR 4.97, 95% CI 1.51–16.4, p < 0.01) and usage of PEEK implant (OR 2.24, 95% CI 1.04–4.83, p = 0.04) as independent predictors of pseudarthrosis. CONCLUSIONS In patients who underwent single-level ACDF, rates of pseudarthrosis associated with the use of the osteobiologic agent Osteocel are higher than the literature-reported rates associated with the use of alternative osteobiologics. This is especially true when Osteocel is combined with a PEEK implant.


Author(s):  
Kai-Uwe Lewandrowski ◽  
Joseph D. Gresser ◽  
Debra J. Trantolo ◽  
Georg Schollmeier ◽  
Frank Kandziora ◽  
...  

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