scholarly journals Degradation and osteogenic potential of a novel poly(lactic acid)/nano-sized β-tricalcium phosphate scaffold

2012 ◽  
pp. 5881 ◽  
Author(s):  
Lu Cao ◽  
Duan ◽  
Wang ◽  
Li ◽  
Yuan ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Tricalcium Phosphate ◽  
Osteogenic Potential ◽  
Poly Lactic Acid ◽  
Beta Tricalcium Phosphate

scholarly journals The effect of beta-tricalcium phosphate on mechanical and thermal performances of poly(lactic acid)

2016 ◽  
Vol 50 (30) ◽  
pp. 4189-4198 ◽  
Author(s):  
JM Ferri ◽  
I Gisbert ◽  
D García-Sanoguera ◽  
MJ Reig ◽  
R Balart
Keyword(s):  
Thermal Analysis ◽  
Lactic Acid ◽  
Tricalcium Phosphate ◽  
Mechanical Performance ◽  
Poly Lactic Acid ◽  
Mechanical Resistance ◽  
Dynamical Response ◽  
Scanning Calorimetry ◽  
Base Materials ◽  
Beta Tricalcium Phosphate

Orthophosphates are bioactive crystals with similar structure, in terms of elemental composition and crystal nature, to human bone. In this work, biocomposite materials were prepared with poly(lactic acid) (PLA) as matrix, and beta-tricalcium phosphate (β-TCP) as osteoconductive filler by extrusion-compounding followed by conventional injection molding. The β-TCP load content was varied in the 10–40 wt% range and the influence of the β-TCP load on mechanical performance of PLA/β-TCP composites was evaluated. Mechanical properties of composites were obtained by standardized tensile, flexural, impact, and hardness tests. Thermal analysis of composites was carried out by means of differential scanning calorimetry; degradation at high temperatures was studied by thermogravimetric analysis; and the effect of the β-TCP load on dynamical response of composites was studied by mechanical thermal analysis in torsion mode. The best-balanced properties were obtained for PLA composites containing 30 wt% β-TCP with a remarkable increase in the Young’s modulus. These materials offer interesting properties to be used as base materials for medical applications such as interference screws due to high stiffness and mechanical resistance.

scholarly journals Fabrication and evaluation of poly(lactic acid), chitosan, and tricalcium phosphate biocomposites for guided bone regeneration

2018 ◽  
Vol 135 (39) ◽  
pp. 46692 ◽  
Author(s):  
Srikanthan Ramesh ◽  
Lisa Lungaro ◽  
Dimitrios Tsikritsis ◽  
Eric Weflen ◽  
Iris V. Rivero ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Guided Bone Regeneration ◽  
Poly Lactic Acid

scholarly journals Osteoconductivity of Hydrothermally Synthesized Beta-Tricalcium Phosphate Composed of Rod-Shaped Particles under Mechanical Unloading

2008 ◽  
Vol 396-398 ◽  
pp. 253-256 ◽  
Author(s):  
Yoshinori Gonda ◽  
Koji Ioku ◽  
Takatoshi Okuda ◽  
Yasuaki Shibata ◽  
Masanobu Kamitakahara ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Wistar Rat ◽  
The Other ◽  
Osteogenic Potential ◽  
Bone Apposition ◽  
Osteoclast Activity ◽  
Mechanical Unloading ◽  
Beta Tricalcium Phosphate ◽  
Sciatic Neurectomy ◽  
The Right

Spherical beta-tricalcium phosphate (b-TCP) granules synthesized using a unique dropping slurry method expressed good osteoconductivity with prominent bone apposition and bioresorbability when implanted into the rat femur (Gonda et al., Key Eng. Mater. 361-363:1013-1016, 2008). The spherical b-TCP granules were implanted into the bone defect created in the distal end of the right femur of each 8-week-old female Wistar rat. To analyze performance of the spherical b-TCP granules as bone substitute in the bone with reduction in osteogenic potential, the right sciatic neurectomy was performed after implantation and the right hind limb was kept unloaded for 2 weeks before euthanization. Four weeks after implantation, some spherical b-TCP granules with resorption in part were surrounded by newly formed bone. Eight and 12 weeks after implantation, most of the residual b-TCP granules were embedded in newly formed bone, and total volume of the implant and newly formed bone was more than the other portions of the bone or the bone of control animals. Osteoclast activity in the implanted area was also higher than the other portions of the bone or the bone of control animals. Replacement of the intraosseous residual b-TCP granules for bone progressed at 12 weeks after implantation compared to those at 8 weeks after implantation. These data suggested that the spherical b-TCP granules stimulated osteogenesis and osteoclast activity of the unloaded bone.

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