scholarly journals Polymeric Nanocarriers for Effective Synergistic Action of Sorafenib Tosylate and Gold-sensitized Gamma Radiation Against HepG2 Cells

2021 ◽  
Vol Volume 16 ◽  
pp. 8309-8321
Author(s):  
Firas Sukkar ◽  
Medhat Shafaa ◽  
Mohamed El-Nagdy ◽  
Wael Darwish
Keyword(s):  
Gamma Radiation ◽  
Hepg2 Cells ◽  
Synergistic Action ◽  
Polymeric Nanocarriers

[6]-Gingerol prevents gamma radiation-induced cell damage in HepG2 cells

2015 ◽  
Vol 305 (1) ◽  
pp. 323-328 ◽  
Author(s):  
Dong-Min Chung ◽  
S. M. Nasir Uddin ◽  
Jin-Hong Kim ◽  
Jin Kyu Kim
Keyword(s):  
Gamma Radiation ◽  
Hepg2 Cells ◽  
Cell Damage ◽  
Radiation Induced

scholarly journals Effervescent Granules Prepared UsingEucommia ulmoidesOliv. and Moso Bamboo Leaves: Hypoglycemic Activity in HepG2 Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-6
Author(s):  
Xiang-Zhou Li ◽  
Sheng Zhang
Keyword(s):  
Hepg2 Cells ◽  
Glucose Consumption ◽  
Synergistic Action ◽  
Moso Bamboo ◽  
Hypoglycemic Activity ◽  
Hypoglycemic Effect ◽  
Western China ◽  
Phyllostachys Pubescens ◽  
Chlorogenic Acids ◽  
Bamboo Leaves

Eucommia ulmoidesOliv. (E. ulmoidesOliv.) and moso bamboo (Phyllostachys pubescens) leaves are used as folk medicines in central-western China to treat diabetes. To investigate the hypoglycemic activity of the effervescent granules prepared usingE. ulmoidesOliv.and moso bamboo leaves (EBEG) in HepG2 cells, EBEG were prepared with 5% of each of polysaccharides and chlorogenic acids from moso bamboo andE. ulmoidesOliv.leaves, respectively. HepG2 cells cultured in a high-glucose medium were classified into different groups. The results displayed EBEG-treated cells showed better glucose utilization than the negative controls; thus, the hypoglycemic effect of EBEG was much greater than that of granules prepared using either component alone, thereby indicating that this effect was due to a synergistic action of the components. Further, glucose consumption levels in the cells treated with EBEG (156.35% at 200 μg/mL) and the positive controls (metformin, 162.29%; insulin, 161.52%) were similar. Thus, EBEG exhibited good potential for use as a natural antidiabetic agent. The hypoglycemic effect of EBEG could be due to the synergistic action of polysaccharides from the moso bamboo leaves and chlorogenic acids fromE. ulmoidesOliv. leaves via the inhibition of alpha-glucosidase and glucose-6-phosphate displacement enzyme.

Hepatic DGAT2 gene expression is regulated by the synergistic action of ChREBP and SP1 in HepG2 cells

2016 ◽  
Vol 20 (1) ◽  
pp. 7-14 ◽  
Author(s):  
Eunji Shin ◽  
Jin-Sik Bae ◽  
Jung-Youn Han ◽  
Junghoon Lee ◽  
Yun-Seung Jeong ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepg2 Cells ◽  
Synergistic Action

Effects of sterilization modes on the mechanical strengths of plaster of paris implants

1989 ◽  
Vol 47 ◽  
pp. 890-891
Author(s):  
K. Cowden ◽  
B. Giammara ◽  
T. Devine ◽  
J. Hanker
Keyword(s):  
Gamma Radiation ◽  
Calcium Sulfate ◽  
Significant Loss ◽  
Potassium Sulfate ◽  
Limiting Factors ◽  
Radiation Sterilization ◽  
Plaster Of Paris ◽  
Hardness Tester ◽  
Dry Heat ◽  
Calcium Sulfate Hemihydrate

Plaster of Paris (calcium sulfate hemihydrate, CaSO4. ½ H2O) has been used as a biomedical implant material since 1892. One of the primary limiting factors of these implants is their mechanical properties. These materials have low compressive and tensile strengths when compared to normal bone. These are important limiting factors where large biomechanical forces exist. Previous work has suggested that sterilization techniques could affect the implant’s strength. A study of plaster of Paris implant mechanical and physical properties to find optimum sterilization techniques therefore, could lead to a significant increase in their application and promise for future use as hard tissue prosthetic materials.USG Medical Grade Calcium Sulfate Hemihydrate Types A, A-1 and B, were sterilized by dry heat and by gamma radiation. Types A and B were additionally sterilized with and without the setting agent potassium sulfate (K2SO4). The plaster mixtures were then moistened with a minimum amount of water and formed into disks (.339 in. diameter x .053 in. deep) in polyethylene molds with a microspatula. After drying, the disks were fractured with a Stokes Hardness Tester. The compressive strengths of the disks were obtained directly from the hardness tester. Values for the maximum tensile strengths σo were then calculated: where (P = applied compression, D = disk diameter, and t = disk thickness). Plaster disks (types A and B) that contained no setting agent showed a significant loss in strength with either dry heat or gamma radiation sterilization. Those that contained potassium sulfate (K2SO4) did not show a significant loss in strength with either sterilization technique. In all comparisons (with and without K2SO4 and with either dry heat or gamma radiation sterilization) the type B plaster had higher compressive and tensile strengths than that of the type A plaster. The type A-1 plaster however, which is specially modified for accelerated setting, was comparable to that of type B with K2SO4 in both compressive and tensile strength (Table 1).

Use of the comet assay to measure DNA damage in cells exposed to photosensitizers and gamma radiation

1999 ◽  
Vol 96 (1) ◽  
pp. 143-146 ◽  
Author(s):  
J.-P. Pouget ◽  
J.-L. Ravanat ◽  
T. Douki ◽  
M.-J. Richard ◽  
J. Cadet
Keyword(s):  
Dna Damage ◽  
Comet Assay ◽  
Gamma Radiation ◽  
In Cells

Linalool Effect on HepG2 cells: Structure Function Relation

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
J Usta ◽  
K Racha ◽  
K Boushra ◽  
S Shatha ◽  
B Yolla ◽  
...  
Keyword(s):  
Structure Function ◽  
Hepg2 Cells ◽  
Function Relation

Transcriptome analysis in HepG2 cells revealed multiple activity mechanisms of a Tibetan polyherbal formula

2012 ◽  
Vol 33 (S 01) ◽  
Author(s):  
K Becker ◽  
A Klein ◽  
OA Wrulich ◽  
P Gruber ◽  
D Fuchs ◽  
...  
Keyword(s):  
Transcriptome Analysis ◽  
Hepg2 Cells
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