scholarly journals Smart Polymeric Nanoparticles with pH-Responsive and PEG-Detachable Properties (II): Co-Delivery of Paclitaxel and VEGF siRNA for Synergistic Breast Cancer Therapy in Mice

2021 ◽  
Vol Volume 16 ◽  
pp. 5479-5494
Author(s):  
Mingji Jin ◽  
Yan Hou ◽  
Xiuquan Quan ◽  
Liqing Chen ◽  
Zhonggao Gao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Polymeric Nanoparticles ◽  
Ph Responsive ◽  
Breast Cancer Therapy

scholarly journals A pH-responsive complex based on supramolecular organic framework for drug-resistant breast cancer therapy

Drug Delivery ◽  
2021 ◽  
Vol 29 (1) ◽  
pp. 1-9
Author(s):  
Yun-Chang Zhang ◽  
Pei-Yu Zeng ◽  
Zhi-Qiang Ma ◽  
Zi-Yue Xu ◽  
Ze-Kun Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Drug Resistant ◽  
Ph Responsive ◽  
Breast Cancer Therapy ◽  
Organic Framework

scholarly journals Biological Evaluation of pH-Responsive Polymer-Caged Nanobins for Breast Cancer Therapy

ACS Nano ◽  
2010 ◽  
Vol 4 (9) ◽  
pp. 4971-4978 ◽  
Author(s):  
Sang-Min Lee ◽  
Richard W. Ahn ◽  
Feng Chen ◽  
Angela J. Fought ◽  
Thomas V. O’Halloran ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Biological Evaluation ◽  
Ph Responsive ◽  
Breast Cancer Therapy ◽  
Responsive Polymer

scholarly journals An Overview of Antibody Conjugated Polymeric Nanoparticles for Breast Cancer Therapy

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 802
Author(s):  
Alberto Juan ◽  
Francisco J. Cimas ◽  
Iván Bravo ◽  
Atanasio Pandiella ◽  
Alberto Ocaña ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Bystander Effect ◽  
Polymeric Nanoparticles ◽  
Mutant Cell ◽  
Surrounding Tissue ◽  
Target Cells ◽  
Breast Cancer Therapy ◽  
Surface Receptors ◽  
Her2 Breast Cancer

Nanoparticles (NPs) are promising drug delivery systems (DDS) for identifying and treating cancer. Active targeting NPs can be generated by conjugation with ligands that bind overexpressed or mutant cell surface receptors on target cells that are poorly or not even expressed on normal cells. Receptor-mediated endocytosis of the NPs occurs and the drug is released inside the cell or in the surrounding tissue due to the bystander effect. Antibodies are the most frequently used ligands to actively target tumor cells. In this context, antibody-based therapies have been extensively used in HER2+ breast cancer. However, some patients inherently display resistance and in advanced stages, almost all eventually progress. Functionalized NPs through conjugation with antibodies appear to be a promising strategy to optimize targeted therapies due to properties related to biocompatibility, suitable delivery control and efficiency of functionalization. This review is focused on the different strategies to conjugate antibodies into polymeric NPs. Recent antibody conjugation approaches applied to the improvement of breast cancer therapy are highlighted in this review.

Targeted delivery of quercetin via pH-responsive zinc oxide nanoparticles for breast cancer therapy

2019 ◽  
Vol 100 ◽  
pp. 129-140 ◽  
Author(s):  
Pritam Sadhukhan ◽  
Mousumi Kundu ◽  
Sharmistha Chatterjee ◽  
Noyel Ghosh ◽  
Prasenjit Manna ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Zinc Oxide ◽  
Cancer Therapy ◽  
Targeted Delivery ◽  
Zinc Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Ph Responsive ◽  
Breast Cancer Therapy

Multifunctional sharp pH-responsive nanoparticles for targeted drug delivery and effective breast cancer therapy

2019 ◽  
Vol 7 (4) ◽  
pp. 576-585 ◽  
Author(s):  
Yandan Yao ◽  
Phei Er Saw ◽  
Yan Nie ◽  
Ping-Pui Wong ◽  
Linjia Jiang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Anticancer Drug ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Breast Cancer Therapy ◽  
Anticancer Drug Delivery ◽  
Targeted Drug

A new multifunctional pH-responsive NP platform was developed for targeted anticancer drug delivery and effective breast cancer therapy.

A pH-responsive natural cyclopeptide RA-V drug formulation for improved breast cancer therapy

2015 ◽  
Vol 3 (22) ◽  
pp. 4514-4523 ◽  
Author(s):  
Zeng-Ying Qiao ◽  
Di Zhang ◽  
Chun-Yuan Hou ◽  
Si-Meng Zhao ◽  
Ya Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Tumor Therapy ◽  
Ph Sensitive ◽  
Drug Formulation ◽  
Ph Responsive ◽  
Breast Cancer Therapy

The co-encapsulation of RA-V cyclopeptide and SQ molecules in pH-sensitive PAE micelles for efficient tumor therapy and imaging in vitro and in vivo.

scholarly journals A pH-responsive complex based on supramolecular organic framework for drug-resistant breast cancer therapy

Drug Delivery ◽  
2021 ◽  
Vol 29 (1) ◽  
pp. 128-137
Author(s):  
Yun-Chang Zhang ◽  
Pei-Yu Zeng ◽  
Zhi-Qiang Ma ◽  
Zi-Yue Xu ◽  
Ze-Kun Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Drug Resistant ◽  
Ph Responsive ◽  
Breast Cancer Therapy ◽  
Organic Framework

scholarly journals pH-responsive and targeted delivery of curcumin via phenylboronic acid-functionalized ZnO nanoparticles for breast cancer therapy

2019 ◽  
Vol 18 ◽  
pp. 161-172 ◽  
Author(s):  
Mousumi Kundu ◽  
Pritam Sadhukhan ◽  
Noyel Ghosh ◽  
Sharmistha Chatterjee ◽  
Prasenjit Manna ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Zno Nanoparticles ◽  
Targeted Delivery ◽  
Phenylboronic Acid ◽  
Ph Responsive ◽  
Breast Cancer Therapy

A tumor microenvironment (TME)-responsive nanoplatform for systemic saporin delivery and effective breast cancer therapy

2021 ◽  
Author(s):  
Qian Shen ◽  
Lei Xu ◽  
Rong Li ◽  
Guang Wu ◽  
Senlin Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Tumor Growth ◽  
Intracellular Delivery ◽  
Ph Responsive ◽  
Breast Cancer Therapy ◽  
Effective Inhibition ◽  
Inhibition Of Tumor Growth

A robust TME pH-responsive nanoplatform was herein developed. This nanoplatform could significantly improve intracellular delivery of cytotoxic saporin to achieve an effective inhibition of tumor growth of breast cancer.

scholarly journals The Potential Cytotoxic Activity Enhancement of α-Mangostin in Chitosan-Kappa Carrageenan-Loaded Nanoparticle against MCF-7 Cell Line

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1681
Author(s):  
Nasrul Wathoni ◽  
Lisna Meylina ◽  
Agus Rusdin ◽  
Ahmed Fouad Abdelwahab Mohammed ◽  
Dorandani Tirtamie ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Physicochemical Properties ◽  
Polymeric Nanoparticles ◽  
Breast Cancer Therapy ◽  
Polymeric Nanoparticle ◽  
Nanoparticle Formulation ◽  
Kappa Carrageenan ◽  
Mcf 7

α-mangostin (αM), a xanthone derivative compound isolated from the extract of mangosteen pericarp (Garcinia mangostana L), has potential anticancer properties for breast cancer. However, it has poor solubility in water and low selectivity towards cancer cells. The polymeric nanoparticle formulation approach can be used to overcome these problems. In this study, a chitosan biopolymer-based αM polymeric nanoparticle formulation was encapsulated using kappa carrageenan (αM-Ch/Cr) as a novel carrier for breast cancer therapy and evaluated for their physicochemical properties, drug release profile, and in vitro cytotoxicity against breast cancer cells (MCF-7). Polymeric nanoparticles formulated with varying concentrations of kappa carrageenan were successfully prepared by ionic gelation and spray pyrolysis techniques. αM-Ch/Cr nanoparticles formed perfectly round particles with a size of 200–400 nm and entrapment efficiency ≥ 98%. In vitro release studies confirmed that αM-Ch/Cr nanoparticles had a sustained release system profile. Interestingly, the formulation of polymeric nanoparticles significantly (p < 0.05) increased the cytotoxicity of αM against MCF-7 cell with IC50 value of 4.7 μg/mL compared to the non-nanoparticle with IC50 of 8.2 μg/mL. These results indicate that αM-Ch/Cr nanoparticles have the potential to improve the physicochemical properties and cytotoxicity effects of αM compounds as breast cancer therapy agents.

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