scholarly journals Neuroprotective Effects of VEGF-A Nanofiber Membrane and FAAH Inhibitor URB597 Against Oxygen–Glucose Deprivation-Induced Ischemic Neuronal Injury

2021 ◽  
Vol Volume 16 ◽  
pp. 3661-3678
Author(s):  
Da-Peng Wang ◽  
Kai-Yan Jin ◽  
Peng Zhao ◽  
Qi Lin ◽  
Kai Kang ◽  
...  
Keyword(s):  
Neuronal Injury ◽  
Glucose Deprivation ◽  
Oxygen Glucose Deprivation ◽  
Nanofiber Membrane ◽  
Neuroprotective Effects ◽  
Ischemic Neuronal Injury

scholarly journals Combination of mild hypothermia with neuroprotectants has greater neuroprotective effects during oxygen-glucose deprivation and reoxygenation-mediated neuronal injury

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Xiao-Ya Gao ◽  
Jian-Ou Huang ◽  
Ya-Fang Hu ◽  
Yong Gu ◽  
Shu-Zhen Zhu ◽  
...  
Keyword(s):  
Cortical Neurons ◽  
Mild Hypothermia ◽  
Neuronal Damage ◽  
Combined Treatment ◽  
Neuronal Injury ◽  
Glucose Deprivation ◽  
Oxygen Glucose Deprivation ◽  
Single Treatment ◽  
Neuroprotective Effects ◽  
Apoptosis Pathway

Abstract Co-treatment of neuroprotective reagents may improve the therapeutic efficacy of hypothermia in protecting neurons during ischemic stroke. This study aimed to find promising drugs that enhance the neuroprotective effect of mild hypothermia (MH). 26 candidate drugs were selected based on different targets. Primary cultured cortical neurons were exposed to oxygen-glucose deprivation and reoxygenation (OGD/R) to induce neuronal damage, followed by either single treatment (a drug or MH) or a combination of a drug and MH. Results showed that, compared with single treatment, combination of MH with brain derived neurotrophic factor, glibenclamide, dizocilpine, human urinary kallidinogenase or neuroglobin displayed higher proportion of neuronal cell viability. The latter three drugs also caused less apoptosis rate in combined treatment. Furthermore, co-treatment of those three drugs and MH decreased the level of reactive oxygen species (ROS) and intracellular calcium accumulation, as well as stabilized mitochondrial membrane potential (MMP), indicating the combined neuroprotective effects are probably via inhibiting mitochondrial apoptosis pathway. Taken together, the study suggests that combined treatment with hypothermia and certain neuroprotective reagents provide a better protection against OGD/R-induced neuronal injury.

scholarly journals Neuroprotective effects of leonurine against oxygen–glucose deprivation by targeting Cx36/CaMKII in PC12 cells

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0200705 ◽  
Author(s):  
Jiao Li ◽  
Shuang Zhang ◽  
Xiaoxi Liu ◽  
Deping Han ◽  
Jianqin Xu ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Glucose Deprivation ◽  
Oxygen Glucose Deprivation ◽  
Neuroprotective Effects

Overexpression of miR-217-5p protects against oxygen–glucose deprivation/reperfusion-induced neuronal injury via inhibition of PTEN

Human Cell ◽  
2020 ◽  
Vol 33 (4) ◽  
pp. 1026-1035 ◽  
Author(s):  
Zhongquan Yi ◽  
Yuanyuan Shi ◽  
Panwen Zhao ◽  
Yun Xu ◽  
Pinglei Pan
Keyword(s):  
Neuronal Injury ◽  
Glucose Deprivation ◽  
Oxygen Glucose Deprivation
Sign in / Sign up

Export Citation Format

Share Document